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Synthetic process of 6-bromo-3-chlorophenyl methyl-2-methoxyquinoline

A technology of methoxyquinoline and chlorophenylmethyl, which is applied in the field of synthesis technology of 6-bromo-3-chlorophenylmethyl-2-methoxyquinoline, can solve the problem of low production efficiency and production process Complexity, high cost and other problems, to achieve the effect of increasing productivity, overcoming more processes, and improving work efficiency

Inactive Publication Date: 2016-05-11
QINGDAO SHOUTAI AGRI SCI & TECH CO LTD
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  • Description
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Problems solved by technology

In the current synthetic process method of 6-bromo-3-chlorophenylmethyl-2-methoxyquinoline, technological process is not easy to implement, and the 6-bromo-3-chlorophenylmethyl-2-methyl of generation The finished product of oxyquinoline has low purity, low single-pass conversion rate of reactants, complex production process, low production efficiency and high cost, and is not suitable for large-scale production

Method used

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Embodiment

[0016] The synthesis technique of the 6-bromo-3-chlorophenylmethyl-2-methoxyquinoline of the present embodiment comprises the following steps:

[0017] (1) The synthesis of 3-benzyl-6-bromo-2-chloroquinoline is cooled in an ice-salt bath, and 84 mL of trichloroxy is added in a double-neck flask, and DMF31 mL is slowly added dropwise under stirring, and the dropping temperature is 20° C. , heated to 35°C to dissolve the solid into a brown liquid;

[0018] (2) Add 34.3 g of N-(4-bromophenyl)-3-phenylpropanamide and react overnight at 80°C;

[0019] (3) Slowly pour into 800mL ice water and stir rapidly;

[0020] (4) extracted three times with dichloromethane, combined the organic layers, washed with water, dried with MgSO4, then evaporated to dryness, and the residue was separated by column chromatography;

[0021] (5) Synthesis of 3-benzyl-15-bromo-2-methoxyquinoline Add 23.6 g of 3-benzyl-6-bromo-2-chloroquinoline and 200 mL of anhydrous methanol into a one-necked bottle, and...

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Abstract

The invention discloses a synthetic process of 6-bromo-3-chlorophenyl methyl-2-methoxyquinoline, in particular to the synthetic process of 6-bromo-3-chlorophenyl methyl-2-methoxyquinoline. The synthetic process of 6-bromo-3-chlorophenyl methyl-2-methoxyquinoline provided by the invention is less in synthetic procedures, short in time and high in yield; the synthetic process comprises the following processing steps: synthesizing 3-benzyl-6-bromo-2-chloroquinoline, synthesizing 3-benzyl-15-bromo-2-methoxyquinoline and synthesizing 6-bromo-3-chlorophenyl methyl-2-methoxyquinoline.

Description

technical field [0001] The invention belongs to the technical field of chemical synthesis, and in particular relates to a synthesis process of 6-bromo-3-chlorophenylmethyl-2-methoxyquinoline. Background technique [0002] The synthesis process of 6-bromo-3-chlorophenylmethyl-2-methoxyquinoline at least includes extraction, distillation, chromatography, stirring and other processes. In the current synthetic process method of 6-bromo-3-chlorophenylmethyl-2-methoxyquinoline, technological process is not easy to implement, and the 6-bromo-3-chlorophenylmethyl-2-methyl of generation The finished product of oxyquinoline has low purity, low single-pass conversion rate of reactants, complex production process, low production efficiency and high cost, and is not suitable for large-scale production. Contents of the invention [0003] In order to overcome the above-mentioned technical problems existing in the prior art field, the object of the present invention is to provide a s...

Claims

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Application Information

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IPC IPC(8): C07D215/227
Inventor 张晶
Owner QINGDAO SHOUTAI AGRI SCI & TECH CO LTD
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