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A method for identifying the optical activity of optical isomers

An optical isomerization and compound technology, applied in the direction of polarization effect characteristics, etc., can solve the problems of complicated and cumbersome use process, time-consuming and difficult operation of accessories, and achieve the effect of ensuring food and drug safety, promoting life science, and improving production efficiency.

Active Publication Date: 2018-08-24
BEIJING ACADEMY OF AGRICULTURE & FORESTRY SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The traditional identification method of anti-optical isomers is mainly based on chromatography, which mainly has many problems such as time-consuming, polluting the environment, and low efficiency.
In terms of vibration spectroscopy, the traditional method uses polarization spectroscopy, the use of accessories is complicated and cumbersome, and it is not easy to operate

Method used

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  • A method for identifying the optical activity of optical isomers
  • A method for identifying the optical activity of optical isomers
  • A method for identifying the optical activity of optical isomers

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Follow the steps below to detect the optical activity of sample A to be tested:

[0036] (1) Set the resolution of the Fourier transform mid-infrared spectrometer to 4cm -1 ;

[0037] (2) At a resolution of 4cm -1 Under certain conditions, collect the ATR-MIR spectrum of the sample to be tested, and perform ATR correction to eliminate the refraction difference of mid-infrared light with different wavenumbers in the ATR crystal; the absorbance is used as the ordinate, and the wavenumber is used as the Abscissa, to obtain the sample to be tested in the spectral range of 1800 ~ 1500cm -1 The spectrogram inside (refer to image 3 shown);

[0038] from image 3 Read out the characteristic wavenumber of the sample to be tested in 1 =1734cm -1 Absorbance of 1 is 0.9155, at the characteristic wavenumber 2 =1714cm -1 Absorbance of 2 is 0.9543;

[0039] (3) Calculate the characteristic value of the sample to be tested according to the following formula;

[0040]

...

Embodiment 2

[0044] Adopt the method described in Example 1 to detect the optical rotation of the sample B to be tested, and the specific steps are:

[0045] (1) Set the resolution of the Fourier transform mid-infrared spectrometer to 4cm-1 ;

[0046] (2) At a resolution of 4cm -1 Under the condition, collect the mid-infrared spectrum absorption spectrum of the sample to be tested (refer to image 3 shown), to obtain samples at the characteristic wavenumber 1 =1734cm -1 Absorbance of 1 is 0.9985 and the characteristic wavenumber 2 =1714cm -1 Absorbance of 2 is 0.9601;

[0047] (3) Calculate the characteristic value of the sample to be tested according to the following formula;

[0048]

[0049] (4) After calculation, the characteristic value of the sample to be tested is -19.2<0, and it is judged that the sample to be tested is D-tartaric acid (D-tartaric acid).

[0050] Through the verification of the structure of the sample to be tested, the result of judging that it is D-tar...

Embodiment 3

[0053] In addition, 50 groups of L-tartaric acid and 50 groups of D-tartaric acid with known optical activity were collected according to the method described in Example 1 to collect attenuated total reflection-mid-infrared spectra, and processed according to the above method. The results show that the eigenvalues ​​of L-tartaric acid are all greater than 0, the eigenvalues ​​of D-tartaric acid are all less than 0, and the difference between the minimum value of L-tartaric acid and the maximum value of D-tartaric acid is greater than 30. The above results illustrate that the Fourier transform mid-infrared spectrometer adopted in this embodiment has a spectral resolution of 4cm -1 Under this method, L-tartaric acid and D-tartaric acid can be quickly and non-destructively identified without polarizing accessories.

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Abstract

The invention provides a method for identifying the optical rotation of an optical isocompound. The method comprises the steps of setting a spectrograph to be under specific spectral resolution based on a vibration spectrum technology, obtaining the absorbance of a sample under specific wave number, calculating characteristic values according to the characteristics of the specific wave number and an absorbance value, namely the spectroscopic characteristics of the sample, and whether the compound is a laevo isomer (L-type) or a dextroisomer (D-type) is judged. The method can achieve fast, simple, efficient and environmentally-friendly identification of the optical isocompound without light polarization attachments, the application range of a vibration spectrum is widened, and an important technical means is provided on the aspects of separation and purification, efficient production, safe use and the like of optical isocompounds.

Description

technical field [0001] The invention relates to the field of food and drug safety, in particular to a method for identifying optical activity of optical isomer compounds. Background technique [0002] Organic optical isomers belong to optical isomers in organic geometric isomers. Optical isomers mainly exist in organic matter, especially those containing sp 3 Hybridized carbon atoms in organic matter. When the carbon atom sp 3 When hybridized, its four outer electron orbitals are distributed in a tetrahedral three-dimensional manner. When the 4 outer electron orbitals of the above-mentioned carbon atoms are combined with different functional groups (A, B, C, D), it is called a chiral carbon atom (ie C * ), it produces optical isomers, and the structural schematic diagram is shown in the appendix of the specification figure 1 , where the thin line represents sp 3 Tetrahedral structure of hybridized carbon atoms, thick lines represent chiral carbon atoms (C * ) parallel...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/21
CPCG01N21/21
Inventor 王冬潘立刚王纪华马智宏侯金健靳欣欣万赐晖
Owner BEIJING ACADEMY OF AGRICULTURE & FORESTRY SCIENCES
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