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Nasal spray and preparation method thereof

A production method and technology of nasal spray, applied in the direction of medical formula, aerosol delivery, medical preparations containing active ingredients, etc., can solve the problems of stimulating nasal secretions, excretion, etc., reduce the rate of volatilization loss, reduce the Good dosage and dispersibility

Inactive Publication Date: 2016-06-08
ZHEJIANG MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, some respiratory medicines are mostly administered orally or by injection, and then reach the action site through the internal circulatory system to exert their efficacy. There is no safe and reliable nasal cavity that promotes the movement of nasal cilia and stimulates the excretion of nasal secretions on the market. spray products

Method used

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  • Nasal spray and preparation method thereof
  • Nasal spray and preparation method thereof
  • Nasal spray and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0041] This embodiment provides a nasal spray with a pH value of 6.6 and an osmotic pressure of 316 mmoL / L. The nasal spray includes polyoxyethylene hydrogenated castor oil, L-α-phosphatidylcholine lecithin, injection grade soybean oil, water, essential oil. The essential oil is composed of 1.8-cineole, d-limonene, and α-pinene, and the volume ratio of 1.8-cineole, d-limonene, and α-pinene is 8:30:45.

[0042] Above-mentioned nasal spray is made by following method:

[0043] Step 1: Add 0.6 g of polyoxyethylene hydrogenated castor oil into 100 ml of water, mix and stir to form an aqueous phase solution.

[0044] In the second step, 3 ml of essential oil, 0.3 g of L-α-phosphatidylcholine lecithin and 0.5 g of injection-grade soybean oil were stirred and mixed to obtain an oil phase solution.

[0045] In the third step, the oil phase solution is mixed with the water phase solution, and emulsified at a speed of 10,000 rpm by a high-speed shear emulsifier to obtain coarse milk. ...

Embodiment 2

[0049]This embodiment provides a nasal spray with a pH value of 6.6 and an osmotic pressure of 320 mmoL / L. The nasal spray includes polyoxyethylene hydrogenated castor oil, L-α-phosphatidylcholine lecithin, injection grade soybean oil, water, essential oil. The essential oil is composed of 1.8-cineole, d-limonene, and α-pinene, and the volume ratio of 1.8-cineole, d-limonene, and α-pinene is 12:30:50.

[0050] Above-mentioned nasal spray is made by following method:

[0051] Step 1: Add 1 gram of polyoxyethylene hydrogenated castor oil into 97 milliliters of water, mix and stir to form an aqueous phase solution.

[0052] In the second step, 2.5 ml of essential oil, 0.3 g of L-α-phosphatidylcholine lecithin and 2.4 ml of injection-grade soybean oil were stirred and mixed to obtain an oil phase solution.

[0053] In the third step, the oil phase solution is mixed with the water phase solution, and emulsified at a speed of 11,000 rpm by a high-speed shear emulsifier to obtain c...

Embodiment 3

[0056] This embodiment provides a nasal spray with a pH value of 6.7 and an osmotic pressure of 311 mmoL / L. The nasal spray includes polyoxyethylene hydrogenated castor oil, L-α-phosphatidylcholine lecithin, injection grade soybean oil, water, essential oil. The essential oil is composed of 1.8-cineole, d-limonene, and α-pinene, and the volume ratio of 1.8-cineole, d-limonene, and α-pinene is 12:36:47.

[0057] Above-mentioned nasal spray is made by following method:

[0058] Step 1: Add 3.5 grams of polyoxyethylene hydrogenated castor oil into 130 milliliters of water, mix and stir to form an aqueous phase solution.

[0059] In the second step, 6 mL of essential oil, 1.2 g of L-α-phosphatidylcholine lecithin and 7.8 mL of injection-grade soybean oil were stirred and mixed to obtain an oil phase solution.

[0060] In the third step, the oil phase solution and the water phase solution are mixed at a volume ratio of 8:15, emulsified with a high-pressure homogenizer at 2°C and ...

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Abstract

The invention provides a nasal spray and a preparation method thereof, belonging to the field of Chinese traditional medicine production. The nasal spray is prepared from 25-75muL / mL of active ingredient essential oil, 5-50mg / mL of emulsifier, 25-75muL / mL of oil phase and balance of water, wherein the active ingredient essential oil contains the following components: 1.8-cineole, d-limonene and alpha-pinene. The nasal spray is a submicron emulsion spray and has the advantages of safe and effective ingredients, good absorbing effect of human bodies for effective medicinal ingredients, simple preparation process and favorability for lowering manufacture and use costs.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine pharmacy, in particular to a nasal spray and a preparation method thereof. Background technique [0002] In recent years, due to the continuous deterioration of environmental problems, the incidence of respiratory diseases in cities in my country has increased significantly. Clinical studies have shown that for the treatment and control of respiratory diseases, the key is to ensure the health of the mucociliary transmission system in the human nasal cavity and improve its vitality, so that the dust, pathogenic bacteria and other chemical pollutants settled in the nasal cavity can be removed in time, and the risk of infection can be reduced. At present, some respiratory medicines are mostly administered orally or by injection, and then reach the action site through the internal circulatory system to exert their efficacy. There is no safe and reliable nasal cavity that promotes the moveme...

Claims

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Application Information

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IPC IPC(8): A61K31/35A61K9/12A61K47/44A61P11/00A61K31/015
CPCA61K31/35A61K9/0043A61K9/1075A61K9/12A61K31/015A61K47/44
Inventor 王鸿王玮尚小广王梦娇章艳吴文哲张春艺徐玉倩
Owner ZHEJIANG MEDICAL COLLEGE
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