Method for physically encapsulating, in hydrogel particle, liposome containing active ingredient, and cosmetic composition containing same

An active ingredient, liposome technology, applied in cosmetics, liposome delivery, cosmetic preparations, etc., can solve problems such as difficulty in increasing the inclusion rate, and achieve the effects of preventing photoaging and hair loss.

Inactive Publication Date: 2016-06-08
华斯泰株式会社
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Through the encapsulation method, the biologically useful active substance is included in the hydrophobic polymer, and although it is more common for the water-soluble substance to be included in the hydrophilic polymer, after the inclusion, the useful ingredients will become water-soluble. The phenomenon of diffusion of sexual or hydrophobic phase (phase), so there is still the problem that the inclusion rate itself is difficult to improve

Method used

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  • Method for physically encapsulating, in hydrogel particle, liposome containing active ingredient, and cosmetic composition containing same
  • Method for physically encapsulating, in hydrogel particle, liposome containing active ingredient, and cosmetic composition containing same
  • Method for physically encapsulating, in hydrogel particle, liposome containing active ingredient, and cosmetic composition containing same

Examples

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Embodiment 1

[0051] 【Example 1】 Manufacture of liposomes containing biologically useful active ingredients

[0052] As an example of the present invention, phytosphingosine cyclic phosphate HCl (PCP) was used as a biologically useful active ingredient, and in order to liposome it, the encapsulation method proposed in Registered Patent No. 1261388 was used , and in this example, 1,2-dipalmitoyl-sn-glycerol-3-phosphatidylcholine (1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine) was used as the amphipathic lipid.

[0053] The content of the active ingredient contained in the liposome is preferably about 0.1-10% by weight, more preferably 0.5-5% by weight, and adjusted to 1% by weight in this embodiment. The amphipathic lipid in the liposome can be contained as 5-30% by weight, and the step of passing through a high-pressure high-speed mixer (microfluidizer) is carried out so that the PCP as the active ingredient of the present invention Packaging (packing) between liposome wall membranes,...

Embodiment 2

[0055] [Example 2] Manufacture of W / O emulsion containing liposomes

[0056] A method for producing hydrogel particles containing liposomes produced in [Example 1], which includes the first step of producing a 100% by weight dispersion mixture (Dispersion Fluid), the 100% by weight dispersion The mixture comprises: liposome 1-10% by weight, preferably 5-10% by weight; water-soluble monomer 10-30% by weight; initiator 0.01-5% by weight, preferably 0.1% by weight, containing the desired concentration of active ingredient - 3% by weight, more preferably 0.5-2% by weight; crosslinking agent 0.01-3% by weight, preferably 1-3% by weight; and the remaining amount of purified water. Here, the water-soluble monomer uses 2-methacryloyloxyethylphosphorylcholine (2-methacryloyloxyethylphosphorylcholine), and the cross-linking agent uses N, N'-methylenebisacrylamide (N,N'-methylenebisacrylamide ), and the photoinitiator used 2-hydroxy-2-methylpropiophenone (2-hydroxy-2-methylpropiopheno...

Embodiment 3

[0059] [Example 3] Fabrication of liposome-encapsulated hydrogel particles

[0060] A method for producing hydrogel particles from the liposome-containing W / O emulsion produced in [Example 2] will be described below. The W / O emulsion water phase (water-phase) formed in [Example 2] includes liposomes, a mixture of water-soluble monomers forming hydrogels, initiators and cross-linking agents, by passing the initiator Polymerization of monomers can selectively generate hydrogels. Polymerization conditions can be selectively used in thermal polymerization, photopolymerization, or the like depending on the kind of initiator used.

[0061] When a thermal initiator is used, the polymerization reaction is preferably performed at 70° C. for more than three hours, and when a photoinitiator is used, the polymerization reaction is preferably irradiated with ultraviolet light for 1 minute to 10 minutes at room temperature.

[0062] Preferably, after the polymerization reaction, alcohol...

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Abstract

The present invention relates to a preparation method for physically encapsulating, in a hydrogel particle, a liposome containing an oil-soluble active ingredient, and more particularly, provides a method for physically fixing a liposome to a hydrogel cross-linked network by: preparing a liposome containing at least one in vivo oil-soluble active ingredient among a phytosphingosine derivative, retinol and a derivative thereof, a ceramide, idebenone, and a poorly water soluble hair growth or hair tonic ingredient; obtaining a W/O emulsion containing, in a water phase, the liposome prepared in this way by using a flow fluid mixing method; and selectively polymer cross-linking only the water phase. A hydrogel film is not broken by a surfactant or a salt even after liposome-hydrogel particles prepared by the present invention are mixed into a cosmetic composition, and thus a liposome containing an active ingredient is stably encapsulated inside a hydrogel particle.

Description

technical field [0001] The invention relates to a method for physically encapsulating liposomes (liposomes) containing biologically useful active ingredients in hydrogel (Hydrogel) particles, and provides a method for physically immobilizing liposomes in more detail. A method within a cross-linked configuration of a hydrogel, in which method, after manufacturing liposomes containing at least one or more biologically useful active ingredients, the flow fluid mixing technique of the present invention is used, so that the lipid The body is contained in the water phase (water-phase) of the W / O emulsion (water-in-oil), and only in the water phase (water phase) is selectively exchanged by polymer polymerization. Linking (cross-linking), thus liposomes are physically immobilized within the cross-linked structure of the hydrogel, and the biologically useful active ingredients include phytosphingosine cyclic phosphate HCl (PhytospingosineCyclicPhosphate·HCl, phytosphingosine derivativ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K9/16A61K9/06A61K8/68
CPCA61K8/042A61K8/11A61K8/14A61K8/355A61K8/671A61K8/68A61K9/0014A61K9/127A61K9/5026A61Q5/00A61Q5/06A61Q7/00A61K8/67A61K9/06A61K9/16A61Q19/00
Inventor 柳在浩金成烈
Owner 华斯泰株式会社
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