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Compound pellets of diammonium glycyrrhizinate and entecavir and preparation method thereof

A technology of diammonium glycyrrhizinate and diammonium glycyrrhizinate intestine, which is applied in the field of medicine to achieve the effects of good uniformity, alleviating large differences in distribution and absorption in the body, and convenient simultaneous administration

Active Publication Date: 2017-12-08
CHIA TAI TIANQING PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, in the prior art, there has been no report on the co-compression of two types of micropills with a huge difference in effective content, nor has there been any report on the direct compression of coated micropills without adding any auxiliary materials or blank micropills.

Method used

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  • Compound pellets of diammonium glycyrrhizinate and entecavir and preparation method thereof
  • Compound pellets of diammonium glycyrrhizinate and entecavir and preparation method thereof
  • Compound pellets of diammonium glycyrrhizinate and entecavir and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1: the preparation of diammonium glycyrrhizinate and entecavir compound pellets

[0029] 1) Preparation of diammonium glycyrrhizinate enteric-coated sustained-release pellets

[0030]

[0031] Remarks: The water in the above formulation is dried and removed during the preparation process.

[0032]Preparation method: Weigh the prescribed amount of raw materials and auxiliary materials, mix evenly, use 2% aqueous solution of povidone K30 as an adhesive to make soft materials, extrude and spheronize to prepare drug-containing pill cores, and sieve 24-30 meshes for use. Take the above-mentioned drug-containing pellet cores in a fluidized bed, prepare a coating solution and coat the isolation layer, and the weight of the coating increases by about 5%. Take the drug-containing pellets coated with the isolation coat, prepare an enteric coating solution to coat the enteric layer, and the weight of the coating increases by about 10%, to obtain diammonium glycyrrhi...

Embodiment 2

[0039] Embodiment 2: the preparation of diammonium glycyrrhizinate and entecavir compound pellets

[0040] 1) Preparation of diammonium glycyrrhizinate enteric-coated sustained-release pellets

[0041]

[0042] Remarks: The water in the above formulation is dried and removed during the preparation process.

[0043] Preparation method: Weigh the prescribed amount of raw materials and auxiliary materials, mix evenly, use 2% aqueous solution of povidone K30 as an adhesive to make soft materials, extrude and spheronize to prepare drug-containing pill cores, and sieve 24-30 meshes for use. Take the above-mentioned drug-containing pellet cores in a fluidized bed, prepare a coating solution and coat the isolation layer, and the weight of the coating increases by about 5%. Take the drug-containing pellets coated with the isolation coat, prepare an enteric coating solution to coat the enteric layer, and the weight of the coating increases by about 10%, to obtain diammonium glycyrrh...

Embodiment 3

[0051] Embodiment 3: the preparation of diammonium glycyrrhizinate and entecavir compound pellets

[0052] 1) Preparation of diammonium glycyrrhizinate enteric-coated sustained-release pellets

[0053]

[0054] Remarks: The water in the above formulation is dried and removed during the preparation process.

[0055] Preparation method: Weigh the prescribed amount of raw materials and auxiliary materials, mix evenly, use 2% aqueous solution of povidone K30 as an adhesive to make soft materials, extrude and spheronize to prepare drug-containing pill cores, and sieve 24-30 meshes for use. Take the above-mentioned drug-containing pellet cores in a fluidized bed, prepare a coating solution and coat the isolation layer, and the weight of the coating increases by about 5%. Take the drug-containing pellets coated with the isolation coat, prepare an enteric coating solution to coat the enteric layer, and the weight of the coating increases by about 10%, to obtain diammonium glycyrrh...

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Abstract

The invention belongs to the field of medicinal preparations, and relates to a compound pellet diammonium glycyrrhizinate and entecavir and a preparation method of the compound pellet. The compound pellet is prepared by tabletting a diammonium glycyrrhizinate pellet coated with an isolation layer and an enteric slow release layer, and an entecavir pellet of which the inner part is a pellet core and the outer part is coated with an entecavir drug containing layer according to a reasonable prescription proportion. The obtained compound pellet is high in homogeneous degree, good in compressibility, excellent in dissolution characteristic and better in clinical application prospect.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to an oral solid preparation, in particular to a compound oral solid preparation of diammonium glycyrrhizinate and entecavir. Background technique [0002] Entecavir is a guanosine nucleoside analogue, which has inhibitory effect on hepatitis B virus (HBV) polymerase. It can become active triphosphate through phosphorylation, and the half-life of triphosphate in the cell is up to 15 hours. Therefore, taking it once a day, a dose of 0.5 mg can effectively kill and block the replication process of the virus, and it is the first-line drug for treating HBV on the market. Its structure is shown in formula 1: [0003] [0004] Diammonium glycyrrhizinate is the third-generation extract of the active ingredient of traditional Chinese medicine licorice, which has certain anti-inflammatory, liver cell membrane protection and liver function improvement effects. The existing clinical dosage...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K47/32A61K31/704A61P31/20A61P1/16A61K31/522
CPCA61K9/2027A61K9/2081A61K31/522A61K31/704A61K2300/00
Inventor 王善春王广基张喜全顾红梅孙中英王祥建董平沈军
Owner CHIA TAI TIANQING PHARMA GRP CO LTD
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