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Lacidipine containing pharmaceutical composition for treating hypertension and preparation method thereof

A technology of lacidipine and its composition, which is applied in the field of pharmaceutical composition for treating hypertension and its preparation, can solve the problem of limiting lacidipine, achieve the effects of lowering blood pressure, less side effects, and improving therapeutic effect

Inactive Publication Date: 2016-06-22
JINAN BANGWEN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This adverse reaction limits the clinical use of lacidipine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A pharmaceutical composition for treating hypertension, consisting of the following raw materials in proportions by weight:

[0040] Lacidipine 4g, Jellygrass 3000g, Lemongrass 3000g, Eustoma 3000g, Panax punctata 3000g, Monophyllite 3000g.

[0041] The preparation method of the pharmaceutical composition for treating hypertension:

[0042] a. Add water to decoct jelly grass, liangmianqing, Eustaceus, short handle five plus, monophyll bead, add water for 2 times, add 7 volumes of medicine for the first time, decoct for 1.5 hours, add 5 times the volume of medicine for the second time Measure the water, decoct for 1 hour, combine the decoction liquid, and set aside;

[0043] b. Concentrate the decoction solution at 60°C and -0.06Mpa to a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry po...

Embodiment 2

[0048] A pharmaceutical composition for treating hypertension, consisting of the following raw materials in proportions by weight:

[0049] Racidipine 4.5g, Jellygrass 3500g, Lemongrass 3500g, Eustoma 2500g, Brachycarpana 3500g, Monophylla 2500g.

[0050] The preparation method of the pharmaceutical composition for treating hypertension:

[0051] a. Add water to decoct jelly jelly, liangmianqing, Eustaceus, short handle five plus, and monophyll pearls in water for 2 times, add 8 volumes of water for the first time, decoct for 2 hours, and add 6 volumes of medicine for the second time Double the amount of water, decoct for 1.5 hours, combine the decoction liquid, and set aside;

[0052] b. Concentrate the decoction solution at 55°C and -0.08Mpa to a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain d...

Embodiment 3

[0057] A pharmaceutical composition for treating hypertension, consisting of the following raw materials in proportions by weight:

[0058] Lacidipine 3.5g, Jellygrass 2500g, Lemongrass 2500g, Eustoma 3500g, Brachyphyllum 2500g, Monophyllite 3500g.

[0059] The preparation method of the pharmaceutical composition for treating hypertension:

[0060] a. Add water to decoct jelly jelly, liangmianqing, Eustoma, short handle five plus, monophyllite pearls, add water for 2 times, add 6 volumes of medicine for the first time, decoct for 1 hour, add 4 volumes of medicine for the second time Double the amount of water, decoct for 0.5 hours, combine the decoction liquid, and set aside;

[0061] b. Concentrate the decoction liquid at 65°C and -0.04Mpa into a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dr...

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Abstract

The invention belongs to the technical field of medicines and particularly relates to a lacidipine containing pharmaceutical composition for treating hypertension and a preparation method thereof. The lacidipine containing pharmaceutical composition for treating the hypertension, provided by the invention, is prepared from the following raw pharmaceutical materials in parts by weight: 3-5 parts of lacidipine, 2,000-4,000 parts of Mesona chinensis, 2,000-4,000 parts of Maesa indica, 2,000-4,000 parts of Eurya japonica, 2,000-4,000 parts of acanthopanax brachypus and 2,000-4,000 parts of Bulbopyllum psychoon. According to the lacidipine containing pharmaceutical composition for treating the hypertension and the preparation method thereof, the traditional Chinese medicines and the lacidipine are combined, so that common adverse reactions of the lacidipine can be avoided, and the treatment effect on the hypertension is improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition containing lacidipine for treating hypertension and a preparation method thereof. Background technique [0002] Hypertension is an important etiology and risk factor of cardiovascular and cerebrovascular diseases, and 20%-30% of people worldwide suffer from hypertension. High blood pressure can affect the structure and function of the heart, brain, and kidney, and significantly increase the risk of stroke, heart failure, and end-stage renal disease. Essential hypertension accounts for 95% of the incidence of hypertension. The survey in 2002 showed that the prevalence rate of people over the age of 18 in my country was as high as 18.8%, and the number of patients reached 160 million. Therefore, the prevention and treatment of hypertension has become a major public health issue that is of the greatest concern in my country and the world. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61K9/16A61K31/4422A61P9/12
CPCA61K9/1652A61K31/4422A61K36/185A61K36/254A61K36/53A61K36/82A61K36/898A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 不公告发明人
Owner JINAN BANGWEN MEDICAL TECH
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