Production method for preparing substance taking plasmalogen as effective ingredient and being used for treating cranial nerve diseases from biological materials

A technology of plasmalogens and biomaterials, applied in nervous system diseases, edible phospholipid compositions, chemical instruments and methods, etc., can solve problems such as complex steps, improve learning and memory, improve safety, improve and treat memory disorders Effect

Inactive Publication Date: 2016-07-06
马腾
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] However, in order to extract a relatively large amount of plasmalogen from food, animal tissue, each method in the prior art requires complicated steps

Method used

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  • Production method for preparing substance taking plasmalogen as effective ingredient and being used for treating cranial nerve diseases from biological materials

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Embodiment Construction

[0063] For ease of understanding, the present invention will be further specifically described below in conjunction with the examples:

[0064] A production method of a substance for treating cranial nerve diseases with plasmalogen as an active ingredient:

[0065] Among them: the biological tissue used is egg-laying waste chicken skin

[0066] The meanings of plPC and plPE are as follows.

[0067] plPC: plasmalogen phosphatidylcholine

[0068] plPE: plasmalogen phosphatidylethanolamine

[0069] The steps are as follows:

[0070] (1) Deoiling of minced chicken skin and extraction and separation of total lipids from its freeze-dried product

[0071] The minced chicken skin obtained from the skin of culled laying hens was deoiled and concentrated, and then freeze-dried by the usual method for total lipid extraction.

[0072] (2) The extract prepared in (1) was hydrolyzed with phospholipase A1 (PLA1). Plasmalogen is not affected by PLA1 because its sn-1 is an ether bond. T...

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Abstract

The invention provides a production method for preparing a substance taking plasmalogen as an effective ingredient and being used for treating cranial nerve diseases from biological materials.The production method comprises the processes that 1, the biological materials are extracted through mixed solvent of aliphatic hydrocarbon solvent and water-soluble ketone solvent; 2, an insoluble part obtained in the process 1 is washed with the mixed solvent of the aliphatic hydrocarbon solvent and the water-soluble ketone solvent to obtain crude plasmalogen; 3, a soluble part obtained in the process 1 is treated to obtain crude plasmalogen; 4, a glycerol phosphatide hydrolase-phospholipase acts with the crude plasmalogen obtained in the process 2 to obtain the plasmalogen; 5, the glycerol phosphatide hydrolase-phospholipase acts with the crude plasmalogen obtained in the process 3 to obtain the plasmalogen.The purity of the effective ingredient plasmalogen of the medicine prepared through the method is high, and the plasmalogen is an ingredient contained in biological tissue, so that the preparation safety is very high.

Description

technical field [0001] The present invention relates to a production method of a substance for treating cranial nerve diseases with plasmalogen as an active ingredient and the medicine produced by the method, more specifically, relates to a drug with plasmalogen extracted from biological tissues as an active ingredient A production method of a substance for treating cranial nerve diseases and a medicine produced by the method. Background technique [0002] In recent years, especially in advanced countries, the number of people suffering from neurological diseases has gradually increased. The rapidly advancing aging society and various stresses are believed to be the cause of neurological diseases. That is, it is presumed that the number of people suffering from dementia such as Alzheimer's disease increases due to aging, brain function decline, and certain factors. It is also believed that the number of people suffering from schizophrenia and depression has increased due t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F9/10A61K31/661A61P25/28A61P25/00
CPCC07F9/103A61K31/661
Inventor 马腾
Owner 马腾
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