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Cerebral nerve cell neogenesis agent

A technology of brain nerve cells and new agents, applied in nervous system diseases, cyclic peptide components, food preparation, etc., to achieve the effect of high safety

Inactive Publication Date: 2012-10-03
MARUDAI FOOD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, in Patent Document 2, it is suggested that plasmalogen (phosphatidylethanolamine) has the effect of suppressing the death of nerve cells

Method used

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  • Cerebral nerve cell neogenesis agent
  • Cerebral nerve cell neogenesis agent
  • Cerebral nerve cell neogenesis agent

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0135] Preparation Example 1: Production of Components Containing Biological Tissue-Extracted Plasmalogens

[0136] According to the conventional method, chicken breast meat as bird tissue was collected, chopped into minced meat of about 8 mm, and frozen for preservation after a heating step in order to control microorganisms. Thereafter, freeze-drying is performed by a conventional method, and pulverization is performed by pulverizer treatment. Dried brisket powder is stored airtight with deoxidizer until used for extraction.

[0137]

[0138] step 1)

[0139] 4 L of ethanol was added to 1 kg of the dried breast meat powder obtained as above, and the mixture was stirred at 40° C. for 12 hours and left to stand, and then the extract was separated from the solid matter. To the solid matter, 2.5 L of ethanol was added again, and extraction was performed as described above, and the obtained extracts were combined and filtered through filter paper, and then dried under reduc...

Embodiment 1

[0157] Example 1: Discussion on the Effects of Plasmalogen Extracted from Biological Tissues on Brain Nerve Cells

[0158] In order to investigate the effect of plasmalogen extracted from bird tissue on brain nerve cells, the following experiments were carried out.

[0159]

[0160] AIN-93M (Standard Feed for Nutritional Research of Mice and Rats, published by the National Institute of Nutrition, USA in 1993) (hereinafter also referred to as "normal feed") was purchased as feed for mice used in the experiment. In addition, AIN-93M containing 0.1% by mass of avian tissue-extracted plasmalogen (hereinafter also referred to as "feed containing 0.1% pl") was purchased by special order (both provided by Japan Oriental Yeast Co., Ltd.).

[0161]

[0162] Fourteen aging-accelerated mice, Senescence-Accelerated Mouse-Prone 8 (SAMP8), were purchased from Japan SLC Co., Ltd. and divided into a plasmalogen-administered group (n=7) and a non-administered group (n=7). SAMP8 is a mod...

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PUM

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Abstract

Disclosed are: a novel substance having a cerebral nerve cell neogenesis effect; and a cerebral nerve cell neogenesis agent which comprises the substance and is effective for the treatment and / or prevention of nerve diseases. Specifically disclosed is a cerebral nerve cell neogenesis agent comprising a plasmalogen as an active ingredient. Particularly, a cerebral nerve cell neogenesis agent comprising, as an active ingredient, a plasmalogen extracted from a biological tissue (preferably an avian tissue) that mainly contains ethanolamine plasmalogen and choline plasmalogen is preferred.

Description

technical field [0001] The present invention relates to a brain nerve cell regeneration agent with plasmalogen as active ingredient, more specifically, relates to a brain nerve cell regeneration agent with plasmalogen extracted from biological tissue as active ingredient. Background technique [0002] In recent years, especially in advanced countries, the number of people suffering from neurological diseases has gradually increased. The rapidly advancing aging society and various stresses are believed to be the cause of neurological diseases. That is, it is presumed that the number of people suffering from dementia such as Alzheimer's disease increases due to aging, brain function decline, and certain factors. It is also believed that the number of people suffering from schizophrenia and depression has increased due to various pressures that exist in modern society. [0003] It has been conventionally considered that brain nerve cells contribute significantly to brain func...

Claims

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Application Information

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IPC IPC(8): A61K31/683A61K35/12A61P25/00A61P25/16A61P25/18A61P25/24A61P25/28A61K35/57
CPCA61K38/12A23L1/30A61K35/57A61K31/685A23L33/10A61P25/00A61P25/16A61P25/18A61P25/24A61P25/28A23V2002/00A23V2200/322
Inventor 井福正隆藤野武彦马渡志郎杉山雅昭小玉芳郎府中英孝柚木惠太
Owner MARUDAI FOOD
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