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Method for condensation of Panax notoginsenosides extract

A technology of Panax notoginseng saponins and extracts, which is applied in the field of medical inventions, can solve the problems of insufficient uniform particle size, poor pore structure, poor concentration effect, etc., and achieve high elution efficiency, high recovery rate, and easy operation. easy effect

Inactive Publication Date: 2016-07-27
GUANGXI WUZHOU PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the spherical shape of this type of resin, the particle size height is not uniform enough, and the pore structure is not very good, there are disadvantages of low resolution and insufficient selectivity.
When using this type of resin to elute Panax notoginseng saponins, more eluent is required, and the concentration effect is not good

Method used

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  • Method for condensation of Panax notoginsenosides extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1: the preparation method of Panax notoginseng total saponins extract

[0026] Take 1000g of Panax notoginseng medicinal material, add 60% ethanol 5 times the weight of Panax notoginseng, heat and reflux at 60°C to extract twice, the first time is 3 hours, the second time is 2 hours, the extracts are combined, filtered, and the filtrate is concentrated to a relative density of 1.20, After the concentrated solution is degreased, the obtained extract is adsorbed and eluted by D101 macroporous adsorption resin, and the eluate is adsorbed and decolorized by alumina and activated carbon, and then concentrated to obtain the extract of Panax notoginseng total saponins.

Embodiment 2

[0027] Embodiment 2: the preparation method of Panax notoginseng total saponins extract

[0028] Take notoginseng and grind it into coarse powder 1000g, add 80% ethanol 8000ml to extract for 7 hours, collect the extract, filter, take the filtrate to recover ethanol until it has no alcohol smell, add water to make a solution containing 0.5g of crude drug per 1ml, pass through a macroporous resin column and alumina adsorption, eluting with 65% ethanol, and concentrating the eluent to obtain the extract of Panax notoginseng saponins.

Embodiment 3

[0029] Embodiment 3: the preparation method of Panax notoginseng total saponins extract

[0030] Take Panax notoginseng, make 20 mesh coarse powder, extract 2 times with ethanol, add 10 times of 70% ethanol each time, extract 3 hours each time, combine the extracts, filter, take the filtrate to recover ethanol until it has no alcohol smell, pass Adsorb on a macroporous adsorption resin column with 8 times the weight of Panax notoginseng, collect the eluent, absorb and decolorize, recover the solvent, concentrate, and obtain the extract of Panax notoginseng total saponins.

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Abstract

The invention relates to a method for condensation of a Panax notoginsenosides extract. The method is mainly carried out by using the microspheric silica gel with weak polarity in a condensation process of the Panax notoginsenosides extract, a highly concentrated solution is obtained, and the hydrolysis rate of Panax notoginsenosides in a common condensation process is reduced.

Description

technical field [0001] The invention relates to the field of medical inventions, in particular to a method for concentrating a Panax notoginseng total saponin extract. Background technique [0002] The total saponins of Panax notoginseng are derived from the main root medicinal material of Panax notoginseng, which are often used to promote blood circulation and remove blood stasis, dredge the meridians and activate collaterals, inhibit platelet aggregation and increase blood flow in the heart and brain, and have preventive and therapeutic effects on cardiovascular and cerebrovascular diseases. Its main components are notoginseng saponins R1, ginsenosides Rg1, Re, Rb1 and Rd. The purification process of total notoginseng saponins includes heating extraction, concentration, chromatography and re-concentration. Since the above components are easily hydrolyzed in water, the temperature is too high and the pH If the value deviates too much, the hydrolytic degradation rate will be...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61K125/00
Inventor 李钊文黄宇声兰星徐卓郑志远
Owner GUANGXI WUZHOU PHARMA GRP