Gentamicin degradation fungus and application thereof

Abstract

A fungus (Aspergillus terreus FZC3) with the preservation number of CGMCC No.12072 can be applied to grade gentamycin, and the fungus is inoculated to a system containing gentamycin and is cultured to realize degradation of gentamycin. The fungus is cultured to remove gentamycin in environment, and can be used to process pharmaceutical wastes in order to reduce harms of gentamycin to environment, humans and animals.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a fungus for degrading gentamicin and its application. Background technique [0002] Antibiotics are a class of secondary metabolites produced by microorganisms (including bacteria, fungi, and actinomycetes) that have anti-pathogen or other activities, and can interfere with the developmental functions of other living cells. As antibacterial or bactericidal drugs, antibiotics have been widely used in the treatment of human diseases, livestock and aquaculture, etc., mainly including tetracyclines, sulfonamides, β-lactams, fluoroquinolones, aminoglycosides and large cyclic lactones, etc. my country is a big country in the production and use of antibiotics, with an annual production of 210,000 tons of antibiotics and a usage of 189,000 tons, of which veterinary antibiotics account for more than half of the usage. Studies have found that after organisms ingest a large amount of antibio...

AI Technical Summary

Problems solved by technology

However, according to literature and patent searches, at present, most of the studies are on antibiotic-degrading bacteria such as tetracyclines, sulfonamides, β-lactams, fluoroquinolones and macrolides, and no screening of aminoglycoside antibiotic-degrading bacteria has been found.

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