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Nanoparticle-containing hydrogels

A nanoparticle and metal nanoparticle technology, applied in the direction of medical preparations containing active ingredients, non-active ingredients of polymer compounds, catheters, etc., to achieve the effects of preventing bacterial adhesion, easy application, and superior mechanical strength

Inactive Publication Date: 2016-08-03
AGENCY FOR SCI TECH & RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Acticoat TM Product can only provide up to 7 days of antimicrobial protection

Method used

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Examples

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Embodiment Construction

[0105] Exemplary, non-limiting embodiments of the disclosed nanoparticle-containing hydrogels will now be disclosed.

[0106] As stated above, the present disclosure provides a nanoparticle-containing hydrogel.

[0107] The nanoparticle-containing hydrogel comprises:

[0108] metal nanoparticles, and

[0109] At least one peptide having the general formula:

[0110] Z-(X) a -(Y) b -Z' c

[0111] in

[0112] Z is an N-terminal protecting group;

[0113] X is independently selected at each occurrence from the group consisting of aliphatic amino acids and aliphatic amino acid derivatives;

[0114] Y is independently selected at each occurrence from the group consisting of polar amino acids and polar amino acid derivatives;

[0115] Z' is a C-terminal protecting group;

[0116] a is an integer selected from 1 to 6, preferably 1 to 5;

[0117] b is 0, 1 or 2, preferably 1; and

[0118] c is 0 or 1.

[0119] The metal nanoparticles may be metal nanoparticles, metal oxid...

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PUM

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Abstract

There is provided a nanoparticle-containing hydrogel comprising metal nanoparticles and at least one peptide. The nanoparticle-containing hydrogel may possess antibacterial activity. There is also provided a method for preparing the nanoparticle-containing hydrogel, and compositions and uses thereof.

Description

technical field [0001] The present invention generally relates to nanoparticle-containing hydrogels, compositions thereof, methods of their preparation, and uses thereof. The nanoparticle-containing hydrogels are suitable for use as antimicrobial and / or antibacterial agents. Background technique [0002] In recent years, interest in biomaterials with inherent antimicrobial activity has increased and has been investigated for many different applications including topical application to prevent infection associated with large wounds and to prevent biofilm formation in medical devices. studied. Due to the increase in antibiotic resistant bacteria, there is a growing interest in developing biomaterials containing antibacterial agents such as silver. [0003] Silver compounds such as silver nitrate solutions have traditionally been used in the treatment of human diseases such as gonococcal eye infections, burns and wounds (Kim et al., 2007; Klasen et al., 2000-a; Klasen et al.,...

Claims

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Application Information

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IPC IPC(8): A61K47/42A61L27/52A61K38/08A61K33/38C07K7/06
CPCA61L27/52A61K47/42C07K7/06A61L27/446A61L27/54A61L29/085A61L29/145A61L29/16A61L31/10A61L31/145A61L31/16A61L15/32A61L15/46A61L15/60A61L2300/102A61L2400/12A61L2420/04A61K9/0014A61K9/06A61K9/14C07K17/04A61K33/38A61P17/02A61P31/04C08L77/04A61K9/146
Inventor 夏洛特·A·E·豪泽尔陈加敏M·R·赖特霍费尔
Owner AGENCY FOR SCI TECH & RES
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