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Pharmaceutical composition of benzbromarone and application of pharmaceutical composition in biological medicine

A technology of benzbromarone and composition, applied in pharmaceutical composition and its application field in biomedicine, can solve the problems such as no reports on the correlation between benzbromarone and its pharmaceutical composition and liver cancer, and achieves therapeutic effect. The effect of increasing the effect

Inactive Publication Date: 2016-08-10
宋晓梅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, there has been no report on the correlation between benzbromarone and its pharmaceutical composition and liver cancer

Method used

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  • Pharmaceutical composition of benzbromarone and application of pharmaceutical composition in biological medicine
  • Pharmaceutical composition of benzbromarone and application of pharmaceutical composition in biological medicine
  • Pharmaceutical composition of benzbromarone and application of pharmaceutical composition in biological medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0020] Separation method: (a) crush the dried roots and rhizomes (3kg) of Aster, extract with 75% ethanol under heat reflux (20L×3 times), combine the extracts, concentrate to no alcohol smell (4L), and successively use petroleum ether ( 4L×3 times), ethyl acetate (4L×3 times) and water-saturated n-butanol (4L×3 times) were extracted to obtain petroleum ether extract, ethyl acetate extract and n-butanol extract respectively; (b ) The n-butanol extract in step (a) is removed with AB-8 macroporous resin, and 8 column volumes are eluted with 6% ethanol first, and then 8 column volumes are eluted with 70% ethanol, and 70% of the elution is collected. liquid, concentrated under reduced pressure to obtain 70% ethanol eluted concentrate; (c) 70% ethanol eluted concentrate in step (b) was separated with normal phase silica gel, and the volume ratio was 50:1 (8 column volumes), 25:1 (8 column volumes), ...

Embodiment 2

[0023] Embodiment 2: Therapeutic effect on liver cancer

[0024] 1. Materials and methods

[0025] 1.1 Cells and animals

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PUM

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Abstract

The invention discloses a pharmaceutical composition of benzbromarone and application of the pharmaceutical composition in a biological medicine. The pharmaceutical composition of the benzbromarone contains the benzbromarone and a natural product compound (I), wherein the natural product compound (I) is novel in structure and is separated from dry roots and stems of aster; the benzbromarone and the natural product have good treatments when individually used; the treatment effect on the liver cancer is further improved when the benzbromarone and the natural product work together; the benzbromarone can be developed into the medicine for treating the liver cancer; and compared with the prior art, the pharmaceutical composition has outstanding substantial characteristics and significant progress.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of benzbromarone, in particular to a pharmaceutical composition of benzbromarone and its application in biomedicine. Background technique [0002] Benzbromarone, chemical name (3,5-dibromo-4-hydroxyphenyl)-(2-ethyl-3-benzofuryl)methanone, is a benzofuran-derived things. This product can not only inhibit the reabsorption of uric acid by renal tubules and promote the excretion of uric acid, but also is a good inhibitor of purine oxidase, which can inhibit the production of uric acid and has dual functions for reducing blood uric acid concentration. Its tablets are clinically used to treat primary and secondary hyperuricemia, as well as gout caused by various causes. [0003] Liver cancer is a malignant tumor of the liver, which can be divided into two categories: primary and secondary. Primary malignant tumors of the liver originate from the epithelial or mesenchymal ti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D303/32C07D301/32A61K31/343A61K31/336A61P35/00
CPCC07D303/32A61K31/336A61K31/343C07D301/32A61K2300/00
Inventor 宋晓梅
Owner 宋晓梅
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