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Qingkailing pharmaceutical composition

A composition and drug technology, applied in the field of medicine, can solve the problems of reducing allergic reactions, unable to achieve stability and the like

Active Publication Date: 2016-08-24
SHINEWAY PHARMA GRP LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a traditional Chinese medicine compound, Qingkailing Injection is characterized by "multiple components, multiple links, and multiple targets". Therefore, only controlling the content of several active ingredients is far from achieving the pharmacodynamic stability of the drug
Chinese patent 201010140385.3 provides a pharmaceutical composition that limits the content of amino acids, chlorogenic acid, and nucleoside compounds in addition to the active ingredients of baicalin, bile acid, and geniposide. Allergic reaction, which improves the safety of medication, but only has the same efficacy as the commercially available Qingkailing

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] (1) Add 180kg Radix Radix Radix to 8 times the weight of purified water, decoct twice, each time for 1 hour, combine the decoction, filter, concentrate the filtrate to 80L, let it cool, add ethanol to make the alcohol content reach 60%, 0 Refrigerate at ~4°C for 12 hours, filter, recover ethanol from the filtrate until it has no alcohol smell, add ethanol to make the alcohol content reach 80%, refrigerate at 0~4°C for 12 hours, filter, recover ethanol from the filtrate until it has no alcohol smell, let it cool, adjust When the pH value reaches 7.0, boil and filter while hot to obtain the Radix isatidis extract;

[0046] (2) Add 20kg of Gardenia 8 times the weight of purified water respectively, decoct twice, the first time for 1 hour, and the second time for 0.5 hours, combine the decoction, filter, concentrate the filtrate to 20L, add ethanol to reduce the alcohol content reach 60%, refrigerate at 0-4°C for 12 hours, filter, recover ethanol from the filtrate until the...

Embodiment 2

[0055] (1) Add 220kg Radix Radix to 10 times the weight of purified water, decoct twice, each time for 1 hour, combine the decoction, filter, concentrate the filtrate to 70L, let it cool, add ethanol to make the alcohol content reach 60%, 0 Refrigerate at ~4°C for 12 hours, filter, recover ethanol from the filtrate until it has no alcohol smell, add ethanol to make the alcohol content reach 60%, refrigerate at 0~4°C for 12 hours, filter, recover ethanol from the filtrate until it has no alcohol smell, let it cool, adjust When the pH value reaches 7.0, boil and filter while hot to obtain the Radix isatidis extract;

[0056] (2) Add 27kg of Gardenia 12 times the weight of purified water respectively, decoct twice, the first time for 1 hour, and the second time for 0.5 hours, combine the decoction, filter, concentrate the filtrate to 25L, add ethanol to reduce the alcohol content reach 60%, refrigerate at 0-4°C for 12 hours, filter, recover ethanol from the filtrate until there i...

Embodiment 3

[0065] (1) Add 194kg Radix Radix Radix to 8 times the weight of purified water, decoct twice, each time for 1 hour, combine the decoction, filter, concentrate the filtrate to 70L, let it cool, add ethanol to make the alcohol content reach 60%, 0 Refrigerate at ~4°C for 12 hours, filter, recover ethanol from the filtrate until it has no alcohol smell, add ethanol to make the alcohol content reach 75%, refrigerate at 0~4°C for 12 hours, filter, recover ethanol from the filtrate until it has no alcohol smell, let it cool, adjust When the pH value reaches 7.0, boil and filter while hot to obtain the Radix isatidis extract;

[0066] (2) Add 23kg gardenias to 8 times the weight of purified water, decoct twice, the first time for 1 hour, and the second time for 0.5 hours, combine the decoction, filter, and concentrate the filtrate to 35L, add ethanol to reduce the alcohol content reach 60%, refrigerate at 0-4°C for 12 hours, filter, recover ethanol from the filtrate until there is no...

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Abstract

The invention provides a Qingkailing pharmaceutical composition, made from the following materials: cholic acid, nacre, hyodeoxycholic acid, Fructus Gardeniae, Pulvis Cornus Bubali, Radix Isatidis, baicalin and Flos Lonicerae. The pharmaceutical composition includes the following effective components according to parts by weight: 360-540 parts of baicalin, 155-320 parts of cholic acid, 10-40 parts of geniposide, 2-10 parts of uridine, 1-5 parts of adenosine, 1-5 parts of vernine, 5-15 parts of tryptophan, 0.5-1.5 parts of epigoitrin, 5-15 parts of genipin1-gentiobioside, 1-4 parts of chlorogenic acid, 2-8 parts of caffeic acid, 10-40 parts of ursodesoxycholic acid, 100-300 parts of hyodeoxycholic acid, and 1000-3000 parts of amino acids. Animal experiments show that the pharmaceutical composition of the invention has better effect in treating acute cerebrovascular diseases, infectious diseases and viral hepatitis.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a pharmaceutical composition with the functions of clearing heat and detoxification, reducing phlegm and dredging collaterals, refreshing the mind and resuscitating the mind. Background technique [0002] Qingkailing Injection is a modern traditional Chinese medicine injection developed by dismantling the ancient prescription Angong Niuhuang Pills. Clinically, it is widely used in diseases such as fever, coma, stroke hemiplegia, upper respiratory tract infection, pneumonia, and high fever. Its prescription is composed of cholic acid, hyodeoxycholic acid, mother of pearl, isatis root, buffalo horn, baicalin, gardenia, and honeysuckle. It includes compounds, herbal medicines, and animal medicines. In the existing Chinese medicine injections and oral liquids The active ingredients are the most complex and can best embody the compatibility theory of traditional Chinese medicine p...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61P9/10A61P31/00A61P31/16A61P1/16A61P31/14A61P31/20A61K9/00A61K9/08A61K9/16A61K9/20A61K9/30A61K9/46A61K9/48
CPCA61K9/0007A61K9/0019A61K9/08A61K9/1605A61K9/2031A61K9/2059A61K9/282A61K9/4808A61K9/4816A61K31/192A61K31/198A61K31/216A61K31/405A61K31/421A61K31/575A61K31/7048A61K31/7072A61K31/7076A61K31/708A61K35/32A61K35/618A61K36/195A61K36/315A61K36/355A61K36/744A61K47/44A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 孙胜斌张纲关秀伟孟伟思王志超陈士杰张岩岩刘艳丽刘育强
Owner SHINEWAY PHARMA GRP LTD
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