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Composition containing amoxicillin and potassium clavulanate, and preparation method thereof

A technology of potassium clavulanate and amoxicillin, which is applied in the field of veterinary pharmaceutical preparations and can solve problems such as unstable active ingredients and easy to be quickly destroyed

Inactive Publication Date: 2016-09-07
HUNAN TAIGU BIOLOGICAL VETERINARY DRUG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to solve the above-mentioned technical problems, the present invention provides a composition containing amoxicillin and potassium clavulanate and a preparation method thereof, thereby solving the problem of amoxicillin and potassium clavulanate being unstable to humidity and heat and active ingredients during use. The shortcoming of being easily destroyed quickly provides a more reliable, efficient, low-toxic and safe preparation for the aquaculture industry

Method used

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  • Composition containing amoxicillin and potassium clavulanate, and preparation method thereof
  • Composition containing amoxicillin and potassium clavulanate, and preparation method thereof
  • Composition containing amoxicillin and potassium clavulanate, and preparation method thereof

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Effect test

Embodiment 1-8

[0041] A composition containing amoxicillin and potassium clavulanate is provided, and the components and amounts are shown in Table 1 below.

[0042] Table 1 Each component and its dosage (unit: kg / 100kg)

[0043]

Embodiment 9

[0045] This embodiment provides a method for preparing a composition containing amoxicillin and potassium clavulanate. The formulation of the composition is the same as that of Examples 1, 5, and 6. The preparation method specifically includes the following steps:

[0046] (A) Preparation before operation:

[0047] (1) Pass all components through No. 5 sieve;

[0048] (2) The set ambient temperature is lower than 20℃;

[0049] (3) The relative humidity of the set environment is lower than 30%;

[0050] (B) Mix silica and potassium clavulanate for 5 minutes, then add the complex of sodium dihydrogen phosphate and disodium hydrogen phosphate; mix for 5 minutes, then add amoxicillin trihydrate and mix for 5 minutes, then press the calcium carbonate according to 3: Add 5 in two proportions, each time mixing for 10 minutes;

[0051] (C) After passing the intermediate inspection, sub-package, vacuum-pack, and put food desiccant in the outer packaging.

Embodiment 10

[0053] This embodiment provides a method for preparing a composition containing amoxicillin and potassium clavulanate. The formulation of the composition is the same as that of Examples 3 and 8. The preparation method specifically includes the following steps:

[0054] (A) Preparation before operation:

[0055] (1) Pass all components through No. 5 sieve;

[0056] (2) The set ambient temperature is lower than 20℃;

[0057] (3) The relative humidity of the set environment is lower than 30%;

[0058] (B) Mix silica and potassium clavulanate for 5 minutes, then add the complex of sodium dihydrogen phosphate and disodium hydrogen phosphate; mix for 5 minutes, then add amoxicillin trihydrate and mix for 5 minutes, then add polyethylene glycol 6000 Or mixed with calcium hydrogen phosphate or lactose for 10 minutes, and finally add calcium carbonate and mix for 10 minutes;

[0059] (C) After passing the intermediate inspection, sub-package, vacuum-pack, and put food desiccant in the outer pack...

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Abstract

The invention relates to the field of a veterinary medicine preparation, and concretely provides a composition containing amoxicillin and potassium clavulanate, and a preparation method and a use method thereof. The composition is prepared from the following ingredients in parts by weight: 5 to 15 parts of amoxicillin, 1.375 to 4.125 parts of clavulanate, 1 to 5 parts of stabilizing agents and 1 to 5 parts of diluting agents. The problem of instability since the amoxicillin and the potassium clavulanate can easily absorb moisture in air is solved; the preparation process and the use method are simple; the addition of special equipment is not needed; all auxiliary ingredients are medical grade auxiliary materials; the cost is low; the materials can be easily obtained; no toxicity and no residue exist; and the requirements of safety, effectiveness and quality controllability on the veterinary medicine preparation can be met. The stability of the preparation is improved; the formula cost is also reduced; and the large-scale batch production can be realized.

Description

Technical field [0001] The invention relates to the field of veterinary pharmaceutical preparations, in particular to a composition containing amoxicillin and potassium clavulanate and a preparation and use method thereof. Background technique [0002] Amoxicillin (Amoxicillin) is a semi-synthetic β-lactam broad-spectrum antibiotic. Its structure is composed of the nucleus thiazole ring and β-lactam ring. It is an important part of antibacterial activity. The antibacterial activity disappears after the β-lactam ring is destroyed. Many bacteria that are sensitive to amoxicillin can produce β-lactamase, which destroys the β-lactam ring and makes amoxicillin lose its activity. Clavulanate, also known as clavulanate, is an irreversible competitive β-lactamase inhibitor, which can be firmly combined with the enzyme to inactivate the enzyme. Therefore, the combination of amoxicillin and clavulanic acid in a certain ratio (may be 2:1-14:1, usually 4:1), can produce a synergistic effec...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/43A61K47/12A61K47/04A61K47/02A61P31/04A61K31/424
CPCA61K31/43A61K9/145A61K31/424
Inventor 谭武贵李健林谭石勇吕华林
Owner HUNAN TAIGU BIOLOGICAL VETERINARY DRUG CO LTD
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