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Application of proteasome inhibitor MG-132 to synergist of pyrethroid insecticides

A proteasome inhibitor, MG-132 technology, applied in the fields of pesticides, applications, preservation of human or animal bodies, etc.

Inactive Publication Date: 2016-09-28
NANJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the use of MG-132 for pest control

Method used

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  • Application of proteasome inhibitor MG-132 to synergist of pyrethroid insecticides
  • Application of proteasome inhibitor MG-132 to synergist of pyrethroid insecticides
  • Application of proteasome inhibitor MG-132 to synergist of pyrethroid insecticides

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Embodiment 1

[0031] 1. Plutella xylostella resistant strains

[0032] Plutella xylostella came from the cabbage field in Zhongcao Township, Huaxi District, Guiyang City, Guizhou Province, and the LD of the fourth-instar larvae was measured after one generation of indoor reproduction. 50 value, compared with the fourth instar larvae LD of the sensitive strain of diamondback moth 50 Compared with the values, it was found that the field population of Plutella xylostella was a sensitive population. It was isolated and cultivated as a sensitive strain synchronously. The deltamethrin-resistant strain of Plutella xylostella (resistance multiple >5000) was bred by multi-generation breeding of the sensitive strain of the fourth instar larvae of Plutella xylostella.

[0033] 2. Effect of MG‐132 on the toxicity of deltamethrin

[0034] (1) Changes in cell activity caused by treatment with a specific concentration of MG-132 for different periods of time

[0035] First, Drosophila Kc cells were pre...

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PUM

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Abstract

The invention belongs to the field of control of pest resistance to insecticides, and more specifically relates to an application of a proteasome inhibitor MG-132 to a synergist of pyrethroid insecticides. The proteasome inhibitor MG-132 is used as the synergist of pyrethroid insecticides, dimethyl sulfoxide is used as a solvent in order to prepare the proteasome inhibitor MG-132 whose concentration is 30[mu]M, the proteasome inhibitor MG-132 is sprinkled on eggs and larvae of diamondback moth in fields as well as feed for pretreatment, and after 24 hours of pretreatment, pyrethroid insecticides can be applied. That MG-132 can substantially improve protection effects of deltamethrin is separately proved in individual and cell levels.

Description

technical field [0001] The invention belongs to the field of pest drug resistance prevention and control, and in particular relates to a proteasome inhibitor MG-132 and a method for controlling deltamethrin resistance of diamondback moth. Background technique [0002] The resistance of insects to insecticides is a phenomenon of ecological adaptation and evolution of insects under the long-term selection of insecticides. This complex selection process is clearly associated with multiple metabolisms and regulations, requiring the participation of multiple proteins and enzymes. The proteasome degradation pathway is an important pathway for the degradation of proteins in cells, and is essential for the normal operation of many life functions of cells, such as cell cycle regulation, gene expression, and oxidative stress response. [0003] Deltamethrin is the most virulent variety of synthetic pyrethroid insecticides. It is stable in nature, broad in insecticidal spectrum, and hi...

Claims

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Application Information

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IPC IPC(8): A01N53/08A01N47/12A01P7/00A01P7/04
CPCA01N47/12A01N53/00A01N2300/00
Inventor 程罗根程晨胡俊丽李风良
Owner NANJING NORMAL UNIVERSITY
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