Nano-scale borage oil microemulsion and preparation method thereof

A technology of borage oil and microemulsion, which is applied in the fields of emulsion delivery, pharmaceutical formulations, and medical preparations containing active ingredients, etc. It can solve the problems of ineffective solution and less microemulsion, and achieve easy operation and good dispersibility , Guarantee the effect of stability and solubility

Inactive Publication Date: 2016-09-28
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Borage oil contains a large amount of unsaturated fatty acids, especially γ-linolenic acid, which has a very good effect on improving the skin, but when applying borage oil in the above fields, it is necessary to improve the water solubility of borage oil , it also needs to have good stability and solubility and dispersibility, but there are few microemulsions about borage oil at present, which cannot effectively solve the above-mentioned needs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Step 1: In terms of parts by mass, take 5 parts of borage oil, 3 parts of fatty acid glycerides of citric acid, 3 parts of sorbitan monooleate, 5 parts of sodium cocoyl isethionate, and nutmeg 0.5 part of isopropyl ester, 6 parts of ten polyglycerol monostearate, 5 parts of N-oleoyl sarcosine, 2 parts of polyglycerol fatty acid ester, 0.5 part of sucrose acetate isobutyrate Mechanical stirring is carried out at a temperature of 50 ° C, the stirring speed is 50 rpm, and the stirring is a uniform mixture;

[0022] Step 2: keep the temperature constant, add 10 parts of glycerol, 2 parts of polyethylene glycol 400, and 140 parts of water to the mixture in step 1 by mass parts, add and stir at the same time, and mix until uniform;

[0023] Step 3: Use a high-speed shearing machine to perform high-speed shearing on the homogeneously mixed mixture in step 2. The speed of the high-speed shearing machine is 7000 rpm, and the shearing time is 5 min, which is the prepared nano-siz...

Embodiment 2

[0026] Step 1: In terms of parts by mass, take 2.5 parts of borage oil, 6 parts of fatty acid glycerides of citric acid, 7 parts of sorbitan monooleate, 2 parts of sodium cocoyl isethionate, and nutmeg 3 parts of isopropyl ester, 3 parts of ten polyglycerol monostearate, 2 parts of N-oleoyl sarcosine, 4 parts of polyglycerol fatty acid ester, 2 parts of sucrose acetate isobutyrate, the above ingredients The temperature is 40°C for mechanical stirring, the stirring speed is 150rpm, and the stirring is a uniform mixture;

[0027] Step 2: In parts by mass, keeping the temperature constant, add 6 parts of glycerol, 5 parts of polyethylene glycol 400, and 100 parts of water to the mixture in step 1, stir while adding, and mix until uniform;

[0028] Step 3: Use a high-speed shearing machine to perform high-speed shearing on the homogeneously mixed mixture in step 2. The speed of the high-speed shearing machine is 5000 rpm, and the shearing time is 15 minutes, which is the prepared ...

Embodiment 3

[0031] Step 1: In terms of parts by mass, take 3.5 parts of borage oil, 4 parts of citric fatty acid glycerides, 6 parts of sorbitan monooleate, 3 parts of sodium cocoyl isethionate, and nutmeg 2.5 parts of isopropyl ester, 5 parts of ten polyglycerol monostearate, 4 parts of N-oleoyl sarcosine, 2 parts of polyglycerol fatty acid ester, 1.5 parts of sucrose acetate isobutyrate Mechanical stirring is carried out at a temperature of 50 ° C, the stirring speed is 50 rpm, and the stirring is a uniform mixture;

[0032] Step 2: In terms of parts by mass, keeping the temperature constant, add 9 parts of glycerol, 4 parts of polyethylene glycol 400, and 110 parts of water to the mixture in step 1, stir while adding, and mix until uniform;

[0033] Step 3: Use a high-speed shearing machine to perform high-speed shearing on the homogeneously mixed mixture in step 2. The speed of the high-speed shearing machine is 5500 rpm, and the shearing time is 7 minutes, which is the prepared nano-...

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Abstract

The invention discloses nano-scale borage oil microemulsion and a preparation method of the nano-scale borage oil microemulsion. The nano-scale borage oil microemulsion is prepared from the following components: 2.5 to 5 parts of borage oil, 3 to 6 parts of citric acid fatty acid glyceride, 3 to 7 parts of sorbitan monooleate, 2 to 5 parts of sodium coconut oil acyl hydroxyethyl sulfonate, 0.5 to 3 parts of isopropyl myristate, 3 to 6 parts of polyglycerol-10 monostearate, 2 to 5 parts of N-oil acyl sarcosine, 2 to 4 parts of polyglycerol fatty acid ester, 0.5 to 2 parts of isobutyric acid sucrose acetate, 6 to 10 parts of glycerin, 2 to 5 parts of polyethylene glycerol 400 and 100 to 140 parts of water. The preparation method disclosed by the invention comprises the following steps: heating, mechanical stirring, uniform mixing and high-speed shearing. The nano-scale borage oil microemulsion prepared and obtained the invention has the advantages of small average grain diameter and strong dissolving property; the preparation method has the characteristics such as simple steps and easiness in industrial production.

Description

technical field [0001] The invention belongs to the technical field of oil microemulsion preparation, and in particular relates to a nano-scale borage oil microemulsion and a preparation method thereof. Background technique [0002] Borage oil is rich in essential fatty acids γ-linolenic acid and linoleic acid, which are essential fatty acids but cannot be synthesized by the human body. They must be ingested from the outside and have a good regulating effect on human physiological functions. Borage oil has been shown to be effective in treating and relieving PMS, multiple sclerosis, menopausal problems, heart disease, psoriasis, eczema, and prematurely aging skin. Among them, borage oil can help dilate blood vessels, ensure proper blood flow in and out of the heart, and also help to change the blocking effect caused by arteriosclerosis, and help reduce the cholesterol produced in the liver in the body; in addition, it can effectively improve the body's immunity; Relieves pa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/30A61K9/107A61K47/26A61P15/00A61P15/12A61P9/00A61P17/00A61P9/10A61P37/04A61P29/00A61P5/14A61P5/38
CPCA61K36/30A61K9/1075A61K47/26
Inventor 刘宁李骋李超
Owner SHAANXI UNIV OF SCI & TECH
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