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Traditional Chinese medicinal compound colloidal bismuth pectin capsule for treating peptic ulcer and preparation method thereof

A colloidal bismuth pectin and peptic ulcer technology, which is applied in the field of pharmaceutical preparations, can solve the problems of poor drug adsorption, poor dispersion uniformity, and complicated preparation methods, so as to enhance the body's self-coordination ability, good dispersion, and reduce Effect on gastric irritation

Inactive Publication Date: 2016-10-12
ZHENGZHOU SIBIAN TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation method of this patent is complicated, and the amount of excipients is relatively large, so that the drug cannot be better adsorbed on the surface of the gastric mucosa, and the porogen and disintegrating agent are relatively hygroscopic, and the dispersion uniformity during storage is poor.

Method used

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  • Traditional Chinese medicinal compound colloidal bismuth pectin capsule for treating peptic ulcer and preparation method thereof
  • Traditional Chinese medicinal compound colloidal bismuth pectin capsule for treating peptic ulcer and preparation method thereof

Examples

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Effect test

Embodiment 1

[0036] A colloidal bismuth pectin capsule for treating peptic ulcer with traditional Chinese medicine compound, comprising the following raw materials in parts by weight: 35 parts of colloidal bismuth pectin calculated as bismuth, 15 parts of famotidine, 50 parts of β-lactam antibiotics, and ganoderma lucidum polysaccharide extract 20 parts, hypromellose phthalate 8 parts, microcrystalline cellulose 25 parts and sucrose stearate 20 parts;

[0037] Among them, famotidine is clathrated with permethylated-β-cyclodextrin.

[0038] The inclusion steps of famotidine using permethylated-β-cyclodextrin are as follows:

[0039] 1) Dissolve permethylated-β-cyclodextrin in 0.1mol / L NaOH aqueous solution, and dissolve famotidine in ethanol;

[0040] 2) Add the famotidine obtained in step 1) dropwise into the permethylated-β-cyclodextrin solution with ethanol solution, and clathrate at 35° C. for 1 hour to obtain the clathrate; famotidine and permethylated The molar ratio of methylated-β-c...

Embodiment 2

[0050] A colloidal bismuth pectin capsule for treating peptic ulcer with traditional Chinese medicine compound, comprising the following raw materials in parts by weight: 45 parts of colloidal bismuth pectin calculated as bismuth, 25 parts of lavutidine, 50 parts of β-lactam antibiotics, and 40 parts of Ganoderma lucidum polysaccharide extract 15 parts of hypromellose phthalate, 60 parts of low-substituted hydroxypropyl cellulose and 20 parts of sucrose stearate;

[0051] Among them, lavutidine is clathrated with permethylated-β-cyclodextrin.

[0052] The inclusion steps of lavutidine using permethylated-β-cyclodextrin are as follows:

[0053] 1) Inclusion and dissolution of permethylated-β-cyclodextrin in 1mol / L NaOH aqueous solution, and dissolution of lavutidine in ethanol;

[0054] 2) Add the ethanol solution of lavutidine obtained in step 1) dropwise into the aqueous solution of permethylated-β-cyclodextrin NaOH, and clathrate at 60°C for 6 hours to obtain the clathrate;...

Embodiment 3

[0064] A colloidal pectin bismuth capsule for treating peptic ulcer with traditional Chinese medicine compound, comprising the following raw materials in parts by weight: 40 parts of colloidal bismuth pectin calculated as bismuth, 30 parts of nizatidine, 100 parts of β-lactam antibiotics, and ganoderma lucidum polysaccharide extract 30 parts, 11 parts of hypromellose phthalate, 60 parts of microcrystalline cellulose and 60 parts of sucrose stearate;

[0065] Wherein, nizatidine is clathrated with permethylated-β-cyclodextrin.

[0066] The inclusion steps of nizatidine using permethylated-β-cyclodextrin are as follows:

[0067] 1) Inclusion and dissolution of permethylated-β-cyclodextrin in 0.5mol / L NaOH aqueous solution, and dissolution of nizatidine in ethanol;

[0068] 2) Add the nizatidine ethanol solution obtained in step 1) dropwise into the permethylated-β-cyclodextrin solution, and clathrate at 40°C for 2 hours to obtain the clathrate; nizatidine and permethrin The mo...

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Abstract

The invention discloses a traditional Chinese medicinal compound colloidal bismuth pectin capsule for treating a peptic ulcer and a preparation method thereof. The traditional Chinese medicinal compound colloidal bismuth pectin capsule for treating the peptic ulcer is prepared from the following raw materials in parts by weight: 35-45 parts of colloidal bismuth pectin (metered with the weight of bismuth), 15-25 parts of an acid inhibitor, 50-150 parts of an antibacterial agent, 20-40 parts of ganoderan extracts, 8-15 parts of hydroxypropyl methyl cellulose phthalate, 25-60 parts of a disintegrating agent and 20-60 parts of an emulsifying agent, wherein the acid inhibitor is clad with permethylated-[beta]-cyclodextrin. The obtained capsule is not only good in dispersity and obvious in sustained release effect, but also improves the immunity of an organism, and has an obvious restoring function for the hypoimmunity caused by western medicinal antibiotics.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a colloidal pectin bismuth capsule for treating peptic ulcer with a traditional Chinese medicine compound and a preparation method thereof. Background technique [0002] Colloidal bismuth pectin is a new type of macromolecular bismuth agent with large molecular weight. Colloidal bismuth pectin replaces the medium and small molecular acid radicals in traditional bismuth preparations with biomacromolecular pectinic acid, such as carbonate, nitrate and structural citric acid. Acid radicals, etc., improve the colloidal properties, and the mucous membrane protection effect is stronger. The sol properties formed by colloidal bismuth pectin in acidic medium are better than any other colloidal bismuth agents; under gastroscopy, colloidal bismuth pectin gel tends to deposit more Excellent selective adhesion on ulcerated and bleeding mucosal surfaces. Collo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/732A61K31/715A61K31/7048A61K31/426A61K31/4545A61K31/4439A61K31/43A61K31/4184A61K31/444A61K9/52A61P1/04A61P37/04A61P31/04
CPCA61K33/245A61K9/1652A61K9/5084A61K31/4184A61K31/426A61K31/43A61K31/4439A61K31/444A61K31/4545A61K31/7048A61K31/715A61K36/074A61K2300/00
Inventor 闵玉涛
Owner ZHENGZHOU SIBIAN TECH CO LTD
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