Concentration gradient generator capable of generating arbitrary linear or quadratic profiles
A quadratic curve and concentration gradient technology, applied in the direction of laboratory containers, laboratory utensils, chemical instruments and methods, etc., to achieve the effect of reliability
Inactive Publication Date: 2018-04-13
LIAONING UNIVERSITY OF TECHNOLOGY
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Problems solved by technology
At present, there is no concentration gradient generator that can systematically provide different shapes of concentration gradients at different flow rates, so that the desired concentration gradient can be achieved by controlling the flow rate
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[0018] A specific embodiment of the present invention will be described in detail below in conjunction with the accompanying drawings, but it should be understood that the protection scope of the present invention is not limited by the specific embodiment.
[0019] like figure 1 As shown, the present invention provides a concentration gradient generator capable of producing any linear or quadratic profile, including 2 or 3 inlet ports 1, such as figure 1As shown in (a), when two inlet ports 1 are included, the two inlet ports 1 communicate with the first transverse channel 2 through the channel wall of the first transverse channel 2, and the first transverse channel 2 and the three The upper ports of the first vertical passages 3 are connected, and the three first vertical passages 3 are distributed at equal intervals in order from left to right, and the first vertical passage 3 at the leftmost end is connected to the first transverse passage 2 The left ends of the three firs...
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The invention discloses a concentration gradient generator capable of generating any linear or secondary curve profile. The concentration gradient generator has a simple pipeline connecting structure. When the concentration gradient generator comprises two inlet ends, four layers of branch channels are formed correspondingly; when the concentration gradient generator comprises three inlet ends, three layers of branch channels are formed correspondingly; the branch channels are connected through transverse channels and vertical channels respectively; the inner diameter size of a pipeline needs to be 0.1mm-0.2 mm. By adopting the concentration gradient generator, controllability of a concentration gradient shape is realized, concentration gradient shapes at two inlet-end concentration gradient generator outlets present certain angle changes by adjustment of the flow speed of a solution, and the peak values of concentration gradient shapes at outlets of the three-inlet-end concentration gradient generator present certain concentration changes. The concentration gradient generator has great significance to the research of cell tropism in bioengineering and chemical engineering.
Description
technical field [0001] The invention belongs to the technical field of microfluidic chips, in particular to a concentration gradient generator capable of generating arbitrary linear or quadratic curve profiles. Background technique [0002] The microfluidic chip is an interactive integrated micro-full analysis system. The microfluidic chip has begun to move from the laboratory to the application, which is of great significance to the research and industrialization of the microfluidic chip. The concentration gradient generator is a further application of the microfluidic chip. Organisms can sense a variety of chemical molecular signals in the surrounding environment and change their physiological activities according to the chemical concentration gradient. Using microfluidic chips to simulate the external environment and establish the concentration gradients required for the research of different organisms plays an important role in the fields of drug screening, biotechnolog...
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IPC IPC(8): B01L3/00
CPCB01L3/5027B01L2200/0694B01L2200/12
Inventor 陈雪叶胡增亮沈杰男李铁川
Owner LIAONING UNIVERSITY OF TECHNOLOGY