Alkaloid compounds with novel skeletons in purslane and extraction and separation method thereof

A separation method and purslane technology, which are applied in the preparation of imino compounds, drug combination, organic chemistry, etc., can solve the problems of low structural novelty, and achieve the effects of environmental protection of the process method, simple and fast operation method

Inactive Publication Date: 2016-10-12
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, most of the chemical components isolated from purslane are known, and the structural novelty is low. Therefore, the development and isolation of new compounds in purslane are urgently needed

Method used

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  • Alkaloid compounds with novel skeletons in purslane and extraction and separation method thereof
  • Alkaloid compounds with novel skeletons in purslane and extraction and separation method thereof
  • Alkaloid compounds with novel skeletons in purslane and extraction and separation method thereof

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Embodiment 1

[0048] The invention provides a new skeleton alkaloid compound, the molecular formula is C 18 h 26 N 2 O, the chemical structural formula is:

[0049]

[0050] The new skeleton alkaloid compound is named Oleracimine according to the structure, and Table 1 is the NMR data of the new skeleton alkaloid compound: 1 H-NMR with 13 C-NMR in CDCl 3 middle.

[0051] Table 1: NMR data of the new skeleton alkaloid compound oleracimine of the present invention.

[0052] serial number

δ C

Types of

δ H (J in Hz)

1

N

-

2

65.7

C

-

3

206.2

C

-

4

121.3

C

-

5

169.4

C

-

6

52.3

CH 2

Ha:2.56(1H,d,15.3)

Hb:2.28(1H,d,15.3)

7

38.9

C

-

8

110.7

C

-

9

46.8

CH 2

Ha:2.02(1H,d,13.5)

Hb:1.47(1H,d,13.5)

10

50.6

C

-

11

27.4

CH 3

1.45(3H,s)

12

29.1

CH 3...

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Abstract

The invention especially relates to identified alkaloid compounds with novel skeletons extracted and separated from purslane and an extraction and separation method thereof, belonging to the field of extraction and separation of traditional Chinese medicines. The alkaloid compounds with novel skeletons have molecular formulas of C18H26N2O, C18H24N2O2 and C18H28N2O2, respectively, and are named as oleracimine, oleracimine A and oleracone A, respectively. The invention also provides an extraction and separation method for the novel components. The extraction and separation method successively carries out extraction through water decoction, ethyl acetate extraction and column chromatography on silica gel, an ODS medium-pressure column and Sephadex LH-20 so as to successfully extract and separate the novel alkaloid compounds with unique skeletons. The novel alkaloid compounds have anti-inflammatory, pain-easing and antineoplastic effect. The compounds and salts or derivatives thereof can be used as lead compounds for synthesis of other compounds and as raw materials for development of novel drugs and research on pharmacological activity, and are applicable to preparation of anti-inflammatory, pain-easing and antineoplastic drugs or health products.

Description

technical field [0001] The invention relates to the field of extraction and separation of traditional Chinese medicines, in particular to a new skeleton alkaloid compound extracted, separated and identified from purslane medicinal material and an extraction and separation method thereof. Background technique [0002] Purslane (Portulaca oleracea L.), also known as longevity dish, horse amaranth, is a plant of the family Amaranthaceae. Purslane is drought and waterlogging resistant, light and shade resistant, widely distributed, and rich in resources. It has attracted much attention as a wild plant for both medicine and food. The 2015 edition of "Pharmacopia of the People's Republic of China" recorded the dry aerial parts of purslane as medicine. , has the functions of clearing away heat and detoxification, cooling blood to stop bleeding, and stopping dysentery. [0003] Modern pharmacological studies of purslane have shown that it has the functions of anti-inflammatory and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D471/08C07D225/04C07C249/02C07C251/20A61P29/00A61P35/00
CPCC07C249/02C07C251/20C07D225/04C07D471/08
Inventor 英锡相英哲铭张文洁李翠玉
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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