Nano-silicon dioxide composite hydrogel for 3D printing and wound repair

A technology of nano-silica and composite hydrogel, applied in biochemical equipment and methods, medical science, microorganisms, etc., can solve the problems of poor optical transparency, high brittleness, and low strength, and achieve high toughness, moderate viscosity and hardness , good biocompatibility

Active Publication Date: 2016-10-12
TONGJI UNIV
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

Although the water absorption characteristics and mechanical properties of the hydrogel can be changed by adjusting the degree of chemical crosslinking, the chemically crosslinked poly

Method used

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  • Nano-silicon dioxide composite hydrogel for 3D printing and wound repair
  • Nano-silicon dioxide composite hydrogel for 3D printing and wound repair
  • Nano-silicon dioxide composite hydrogel for 3D printing and wound repair

Examples

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Embodiment 1

[0032] Such as figure 1 Schematic diagram of nano-silica composite hydrogel structure and figure 2 The preparation diagram of nano-silica composite hydrogel is shown as follows:

[0033] A preparation method of nano-silica composite hydrogel that can be used for 3D printing and wound repair is as follows:

[0034] (1) Synthesis of nanocomposite particles: 2.8mL of ethyl orthosilicate was added dropwise to 147mL of absolute ethanol under stirring, and then 3mL of deionized water and 7.5mL of 28% ammonia water were added, and the mixture was uniformly mixed in a water bath at 40℃. Reflux for 8h. Subsequently, 1 mL of the silane coupling agent KH590 was added to the mixed solution and refluxed in a 40°C water bath for 8 hours. The mixed solution was then centrifuged and washed twice to obtain silica nanoparticles with sulfhydryl groups at the end. The centrifuged nanoparticles Disperse in 15mL Tris-HCl (PH=7.2), add 20mg dithiothreitol (DTT) and stir for 1h, the purpose is to open t...

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Abstract

The invention relates to a nano-silicon dioxide composite hydrogel for 3D printing and wound repair, and belongs to a polymeric biomaterial. Nano-silicon dioxide of which the tail end is connected with a beta-dihydroxy compound serves as an initiating agent and a cross-linking agent, gelatin of which the tail end is connected with a double bond serves as a monomer, nano-silicon dioxide and the gelatin are uniformly dispersed in an aqueous solution, and the nano-silicon dioxide composite hydrogel is prepared through enzymatic-catalysis free radical polymerization under the action of glucose and glucose oxidase. The hydrogel can be prepared at room temperature within 6 min to 30 min by adjusting the concentrations of nano-silicon dioxide with the beta-dihydroxy compound, glucose and glucose oxidase. The hydrogel has the advantages of being mild, efficient, good in mechanical property and high in biocompatibility, therefore, the hydrogel can be used for 3D printing and cell culture, and the hydrogel can be used for tissue engineering of wound repair and the like after being loaded with fibroblast growth factors.

Description

Technical field [0001] The invention belongs to the technical field of polymer biomaterials, and specifically refers to a nano-silica composite hydrogel that can be used for 3D printing and wound repair. The hydrogel has biological activity and multifunctionality, and can be used as a carrier of growth factors and cells, and can be applied to the treatment of wound repair. Background technique [0002] Hydrogel is a gel in which water is the dispersion medium. The water-soluble polymer with a network cross-linked structure introduces a part of hydrophobic groups and hydrophilic residues. The hydrophilic residues combine with water molecules to connect the water molecules inside the network, and the hydrophobic residues swell with water. Union polymer. It is a polymer network system, soft in nature, can maintain a certain shape, and can absorb a lot of water. [0003] The usual hydrogel is composed of chemically cross-linked polyelectrolyte such as polyacrylamide or polyacrylic a...

Claims

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Application Information

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IPC IPC(8): C12P21/00C12N5/00A61L27/24A61L27/02A61L27/52A61L27/54A61L27/56A61L27/50A61L27/58B29C67/00B33Y40/00
CPCA61L27/025A61L27/24A61L27/50A61L27/52A61L27/54A61L27/56A61L27/58A61L2300/252A61L2300/412A61L2300/414A61L2300/604A61L2400/06B33Y40/00C12N5/00C12N2533/54C12P21/00
Inventor 吕雅楠王启刚胡文
Owner TONGJI UNIV
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