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Application of GPC1 as tumor diagnosis marker

A technology of tumor diagnosis and markers, applied in the direction of biological testing, material inspection products, measuring devices, etc., can solve the problems of lack of sensitivity and specificity, and achieve good sensitivity and specificity

Active Publication Date: 2016-10-26
ZHONGSHAN HOSPITAL FUDAN UNIV
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Problems solved by technology

However, the tumor markers currently used in clinical practice lack good sensitivity and specificity. Therefore, it is very important to develop new tumor markers with high specificity and sensitivity, which is beneficial to early detection of tumors, prediction of patient prognosis, and personalization. Chemotherapy, and management and follow-up of cancer patients

Method used

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  • Application of GPC1 as tumor diagnosis marker
  • Application of GPC1 as tumor diagnosis marker
  • Application of GPC1 as tumor diagnosis marker

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0022] 1. Experimental method:

[0023] (1) Inclusion of patients and samples:

[0024] In this experiment, a total of 64 patients with pancreatic cancer, 61 patients with esophageal squamous cell carcinoma, 54 patients with gastric adenocarcinoma, 42 patients with colorectal cancer, 30 patients with liver cancer, 30 patients with gastrointestinal polyps, and 7 patients with pancreatitis patients, and 30 normal controls.

[0025] Inclusion and exclusion criteria for tumor patients include: 1) There is a clear pathological diagnosis of the corresponding tumor; 2) The tumor is newly diagnosed and has not received any anti-cancer treatment before; 3) There is no other acute disease or systemic disease such as autoimmune disease , diabetes, coronary heart disease, etc.

[0026] Patients in the control group were required to be free of acute or systemic diseases.

[0027] (2) Sample collection

[0028] After blood samples were collected, they were placed in yellow-head coagulat...

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Abstract

The invention provides application of GPC1 protein as a tumor diagnosis marker. The GPC1 protein can be used for preparing a digestive system malignant tumor diagnosis reagent and kit as a tumor diagnosis marker. The tumor marker GPC1 provided by the invention can be proved to be suitably used as a diagnosis marker of tumor in a digestive system currently in a small-scale clinical sample, has better sensitivity and specificity compared with traditional AFP, CEA, CA199 and the like, and can be used as a tumor marker for mass survey.

Description

technical field [0001] The invention relates to the use of GPC1 as a tumor diagnostic marker for early diagnosis of tumors. Background technique [0002] Tumor markers refer to substances that specifically exist in malignant tumor cells, or are abnormally produced by malignant tumor cells, or are produced by the host in response to stimulation of tumor cells. Tumor markers are a class of substances that can reflect tumor occurrence and development, and monitor tumor response to treatment. Common tumor markers in physical examination include: 1) CEA: common in gastrointestinal cancer, lung cancer, ovarian cancer and other tumors; 2) AFP: the earliest discovered tumor marker, common in primary hepatocellular carcinoma; 3) PSA: common in prostate cancer; 4) CA199: common in pancreatic cancer. However, the tumor markers currently used in clinical practice lack good sensitivity and specificity. Therefore, it is very important to develop new tumor markers with high specificity a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574G01N33/68
CPCG01N33/57484G01N33/68
Inventor 沈锡中陈妍洁吴昊刘韬韬董玲
Owner ZHONGSHAN HOSPITAL FUDAN UNIV
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