Antibacterial supermolecule hybrid hydrogel, preparation method and applications thereof

Abstract

The present invention provides a supermolecule hybrid hydrogel having excellent antibacterial property, a preparation method and applications thereof. The preparation method comprises that Fmoc-Glu-OMe adopted as a gelatin factor, silver nitrate and chitosan are subjected to co-assembly under an ultrasound effect to form a clarified and transparent supermolecule hybrid hydrogel, wherein the uniform size and monodispersed silver nanoparticles are subjected to in situ synthesis in the hydrogel, and the antibacterial property of the supermolecule hybrid hydrogel is substantially improved with the synergistic effect of the three components such as the Fmoc-Glu-OMe, the silver nanoparticles and the chitosan. According to the present invention, the supermolecule hybrid hydrogel has performances such as self-healing, injectability, capability of coating, and the like; the preparation method is simple, has the low cost, and can be commercialized; during the preparation process, any reducing agents and any dispersants are not added, and the silver nanoparticles are synthesized through the ultrasonic in situ synthesis, such that the green environment protection advantage is achieved; and various components of the supermolecule hybrid hydrogel provide the synergistic effect to make the antibacterial property of the composite material be significantly increased, such that the supermolecule hybrid hydrogel has wide application prospects in the field of the antibacterial material and the wound healing promotion.

Description

technical field [0001] The present invention relates to the field of supramolecular hydrogels, in particular to using Fmoc-Glu-OMe as a hydrogel factor, ultrasonically synthesizing silver nanoparticles in situ, adding chitosan, and co-assembling with amino acids to form an antibacterial supramolecular hybrid Preparation method and application of composite hydrogel. Background technique [0002] Despite the rapid development of medical technology, millions of people around the world suffer from infectious diseases caused by bacteria every year. In addition, bacterial resistance to traditional antimicrobial agents is increasing, and the problem of infectious diseases caused by bacteria remains an important health problem to be solved urgently. Therefore, it is becoming more and more important to design and develop new antibacterial agents, especially in the field of biomedical chemistry (Proc. Natl. Acad. Sci. U.S.A., 2006, 103, 15997-16002). Antimicrobial agent is a materia...

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Problems solved by technology

[0005] At present, many documents and patents have reported the use of silver nanoparticle gel as an antibacterial agent, but most of them are unevenly dispersed, and the agglomeration phenomenon is serious, and the antibacterial performance is seriously affected (Chinese invention patent publication CN102218155A); In the case of particles, the chemical reagents with high toxicity are used, the cytotoxicity is high, and the biocompatibility is relatively poor (Chinese Invention Patent Publication CN101664563A); Invention patent publication CN102698313A)

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