coagulation detection device

Abstract

The invention discloses a blood coagulation detector which comprises a base layer of a lamellar structure, a bonding layer of a lamellar structure and a device layer, wherein the device layer comprises a fixed unit, a movable unit and an elastic member; the fixed unit is connected with the base layer through the bonding layer; the movable unit is connected with the fixed unit through the elastic member so that the movable unit is suspended above the base layer; the device layer also comprises a drive capacitor capable of driving the movable unit and a to-be-detected object to do relative motion, a measuring capacitor and a probe; one end of the probe is fixedly connected with the movable unit, and the other end enters the to-be-detected object to do relative motion under the drive of the drive capacitor; the relative motion means that the movable unit reciprocates along a direction and rotates around a direction relative to the to-be-detected object; and the real-time capacitance error of the measuring capacitor is used for calculating the stress of the movable unit reciprocating along a direction and the torque rotating around a direction. The blood coagulation detector disclosed by the invention integrates drive and measurement, has the advantages of high measurement precision, good integration level and low cost and is suitable for batch production.

Description

technical field [0001] The invention relates to the technical field of biomedical detection, and more specifically, the invention relates to a blood coagulation detection device. Background technique [0002] For the detection of indicators of dynamic changes in blood coagulation (including the formation speed of fibrin, the dissolution state and the firmness and elasticity of the coagulation), it is useful for the treatment of hemophilia, the screening of various coagulation abnormalities before and after surgery, and various blood coagulation abnormalities. It is of great significance in the monitoring of the efficacy of a procoagulant antifiber or anticoagulant and other drugs. The blood coagulation and thrombolysis function detection device first appeared in 1948. It uses a spring spring as the core to detect the clot elasticity generated during the coagulation and thrombolysis process. It is reflected on the plotter and draws a curve of the thrombus elasticity changing ...

AI Technical Summary

Problems solved by technology

[0003] At present, the commercial coagulation and thrombolysis function testing market is mainly monopolized by two imported instruments, TEG and ROTEM, and the matching reagents used are mainly from abroad, so the price is relatively expensive

At the same time, these two instruments can only realize one-dimensional measurement of thrombus elastic modulus, and the actual coagulation process is affected by factors such as the aggregation state of red blood cells, the rigidity of red blood cells, and the spatial cross-linking of fibrin. Anisotropic

Thirdly, the drive and detection functions of existing instruments are separated, the instrument structure is complex, and the price is high

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