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Automatic analysis device and analysis method

A technology of automatic analysis device and reference value, which is applied in the direction of measurement device, analysis material, material inspection product, etc., can solve the problems of deviation of measurement value and different blood coagulation time measurement results, and achieve the effect of improving reliability.

Active Publication Date: 2016-11-30
HITACHI HIGH-TECH CORP
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In this way, due to the different measurement methods, even when the same sample is analyzed for the same item, the blood coagulation time measurement results will be different
In addition, the blood coagulation time test reagent contains components derived from living organisms, so the reactivity varies between batches, and the measured value of the blood coagulation time varies.

Method used

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  • Automatic analysis device and analysis method
  • Automatic analysis device and analysis method

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Experimental program
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no. 1 approach ＞

[0055] The first embodiment of the present invention will be described with reference to the drawings.

[0056] In this embodiment, as an example of an automatic analysis device, a blood coagulation time measurement device will be described as an example. The blood coagulation time measurement device will remove a biological sample such as blood or urine based on the amount of change in the optical change. Hereinafter, it is abbreviated as a sample) and the time until fibrin is precipitated when the reagent is mixed is measured as the blood clotting time.

[0057] figure 1 It is a diagram schematically showing the overall configuration of the automatic analyzer of this embodiment.

[0058] in figure 1 Among them, the automatic analyzer 100 is roughly composed of: a sample dispensing probe (sample dispensing mechanism) 101, a sample tray 102, a reagent dispensing probe (reagent dispensing mechanism) 106, a reagent tray 107, and a reaction container storage section 111. The reaction c...

no. 2 approach ＞

[0134] The second embodiment of the present invention will be described with reference to the drawings.

[0135] This embodiment confirms the accuracy of the reagent preparation of the first embodiment applied to freeze-dried reagents.

[0136] For example, a reagent for measuring prothrombin time (hereinafter referred to as PT = Prothrombin time) contains animal-derived tissue thromboplastin, and it is common practice to use freeze-dried reagents in order to maintain stability. In the past, the dissolution of freeze-dried reagents was manually performed by inspection technicians, so there was a problem that fluctuations in measurement values ​​caused by preparation errors could not be controlled in the device. On the other hand, in order to implement the reagent preparation function in the device, a mechanism for distributing the dissolving liquid and a mechanism for stirring the dissolving liquid are required, which leads to problems of increasing the size of the apparatus and in...

no. 3 approach ＞

[0147] The third embodiment of the present invention will be described with reference to the drawings.

[0148] In this embodiment, the signal reference value setting process of the first embodiment is implemented by reflecting the deterioration state of the reagent or the device state (change in light intensity, etc.).

[0149] Figure 26 It is an explanatory diagram showing the day-to-day change of the measurement result of the precision control sample when the analysis item is PT.

[0150] In an automatic analyzer, a sample of known concentration, such as a precision control sample, is used for measurement on a regular basis. In the case of deviation from the expected value determined by the use of a specific batch and sample, it is corrected by calibration It is the usual method. E.g Figure 26 As shown, for the accuracy control of the PT, the accuracy control is performed regularly to check the status of the reagents. Calibration is performed when the measurement result deviat...

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Abstract

A signal reference value (SLocal) is set at which a blood coagulation reaction time (T) of a blood coagulation time reference sample measured on the basis of the result of comparing a signal value (amount of transmitted light, amount of scattered light, amount of fluorescence, or turbidity) pertaining to blood coagulation time that varies temporally according to the mixing and reaction of the blood coagulation time reference sample and a reagent and a signal reference value (S) corresponds to an expected value (Te) for the blood coagulation reaction time that has been set beforehand so as to correspond to the blood coagulation time reference sample. As a result, it is possible to use the blood coagulation time reference sample to determine the state of the reagent and enhance the reliability of measurement results by setting a unique signal reference value for each reagent container.

Description

Technical field [0001] The present invention relates to an automatic analysis device and an analysis method for analyzing biological samples such as blood or urine, and more particularly to a device and method for measuring blood clotting time or measuring cycle time accompanying nucleic acid amplification. Background technique [0002] In terms of automatic analyzers, there are: biochemical automatic analyzers that perform quantitative / qualitative analysis of the component concentrations of biological samples such as blood or urine in the fields of biochemical tests or hematological tests; blood coagulation time to measure blood coagulation time Automatic analyzers (hereinafter sometimes referred to as blood clotting time measuring devices), etc.; nucleic acid amplification inspection devices that measure the cycle time accompanying nucleic acid amplification, and the like. [0003] In the former biochemical automatic analyzer, etc., at the beginning of a day’s analysis or when re...

Claims

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Application Information

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IPC IPC(8): G01N33/86
CPCG01N35/00584G01N35/10G01N2035/0091G01N2035/0097G01N2035/0441G01N2035/0443G01N33/4905G01N33/86G01N35/00693G01N35/00732G01N2035/00702G01N2035/00821G01N2035/009G01N35/00722G01N35/1065G01N2035/00891
Inventor 薮谷千枝牧野彰久松原茂树
Owner HITACHI HIGH-TECH CORP
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