Medical composite chitosan functional dressing and preparation method thereof
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A technology of chitosan and water-soluble chitosan, which is applied in the field of medical supplies, can solve problems such as toxicity, achieve softness and plasticity, reduce the use of cross-linking agents, and avoid residual effects
Inactive Publication Date: 2016-12-14
HANGZHOU YINGJIAN BIOTECHNOLOGY CO LTD
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Problems solved by technology
There are certain shortcomings in these methods, that is, cross-linking agents are used, and their residues have certain toxicity to the human body.
Method used
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Embodiment 1
[0047] A medical composite chitosan functional dressing, which includes water-soluble chitosan or its salt, and carboxymethyl starch or sodium carboxymethyl starch, specifically, includes the following components in parts by mass: carboxymethyl starch Base chitosan 1g, carboxymethyl starch 3g.
Embodiment 2-7
[0049]
[0050] The molecular weight of chitosan hydrochloride is 20000-300000, the degree of deacetylation is 80-95%, the viscosity is 10-120mpa·s, the pH value is 4.0-6.0, and the pH value of the sodium carboxymethyl starch is 5.5-7.5 .
Embodiment 8
[0052] A preparation method of medical composite chitosan functional dressing, is characterized in that, comprises the following steps:
[0053] A. Weigh a certain amount of water-soluble chitosan or its salt and carboxymethyl starch or sodium carboxymethyl starch, put it in a stirrer, add a certain amount of water, stir to make the solution foam and expand, and obtain the prepared solution ,
[0054]B. Weigh the above preparation solution, pour it into a silicone mold tray, put the lid closed and place it in a -20°C refrigerator for quick freezing. The silicone mold tray can be of different specifications, specifically 5cm×5cm, 5cm×10cm, 10cm×10cm , 10cm×20cm, 20cm×20cm, 20cm×30cm, 30cm×30cm, 12.5cm×7.5cm, etc.,
[0055] C, place the quick-frozen molded product in step B to freeze-dry in a vacuum freeze dryer, sterilize and pack after demoulding, and make a composite chitosan functional dressing, and the sterilization can be specifically ethylene oxide sterilization, cobalt ...
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Abstract
The invention belongs to the technical field of a medical article, and relates to a medical composite chitosan functional dressing and a preparation method thereof. The method comprises the following steps of A, weighing a certain amount of water-soluble chitosan or salts and carboxymethyl starch or sodium starch glycolate; putting the materials into a stirring device; adding a certain amount of water; performing stirring so that the solution foams and expands to obtain a preparation solution; B, weighing the preparation solution; injecting the preparation solution into a silicon rubber mold disc; pressing a cap for sealing; then, putting the materials into a -20 DEG C refrigerator for quick freezing and forming; C, putting a quick freezing and forming product in the step B into a vacuum freeze drying machine for freeze drying; performing sterilization and packaging after the demoulding; then performing preparation to obtain the composite chitosan functional dressing. The preparation method provided by the invention has the advantages that the process is simple; the method is suitable for industrial production; the prepared composite chitosan functional dressing has high adsorption capability, high moisture preservation performance and high softness plasticity.
Description
technical field [0001] The invention belongs to the technical field of medical supplies, and relates to a medical composite chitosan functional dressing and a preparation method thereof. Background technique [0002] Medical dressing is a kind of medical material used for temporary covering of various wounds and wound surfaces. It can be used for the absorption of wound exudate, has the functions of stopping bleeding and promoting wound healing, and protects the wound from bacterial infection and other external factors. Impact. An ideal wound covering should have good mechanical properties, physical and chemical properties, and biological properties, and should also have the characteristics of easy preparation, sterilization, storage, and low cost. In the past ten years, with the development of science and technology, the components and types of dressings have undergone great changes. Basic materials commonly used in dressings include natural polymer materials and syntheti...
Claims
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