Dapsone-containing gel preparation and preparation method thereof

A dapsone and gel technology, which is applied in the field of preparation of dapsone gel preparations, can solve the problems of low absorption in vitro, reduce patient compliance, affect the curative effect of dapsone gel, and the like, achieve good curative effect, increase Skin permeability, the effect of killing deep fungus
CN106265489AInactive Publication Date: 2017-01-04BEIJING VENTUREPHARM BIOTECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BEIJING VENTUREPHARM BIOTECH
Publication Date
2017-01-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a dapsone-containing gel preparation and a preparation method thereof and belongs to the new technical field of medicines. The effective ingredient of the gel preparation is dapsone which is a sulfone type bacteriostatic agent, and the gel preparation has a sterilization effect when used in a large-dosage manner, has been used for treating leprosy clinically previously and is found that the gel preparation can also be used for treating nodular acne. A penetration enhancer is preferably selected for the gel preparation, so that the gel preparation has a good penetration property and a high deep sterilization function, can clear deep acne, is convenient to use, attractive in appearance and easy to clean and has no irritation to skin.
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Description

technical field

[0001] The invention belongs to the technical field of pharmaceutical gel preparations, and in particular relates to a preparation method of a dapsone gel preparation with more stable quality and capable of removing deep infection. Background technique

[0002] Dapsone, its chemical name is: 4,4'-sulfonyl dianiline, the English name is Dapsone, and its molecular formula is C 11 h 12 N 2 o 2 S, the molecular weight is 248.31. Its chemical structure is as follows:

[0003]

[0004] Dapsone Gel was developed by Allergan, of which the 5% specification was approved by the US FDA in 2006, and the 7.5% specification was approved by the US FDA in 2016 for the treatment of acne vulgaris. It can effectively clear up acne, and Side effects such as skin redness and dryness are mild.

[0005] ACZONE ® (ACZONE ® It is the product name of this product. It is not yet on the market in China, so there is no Chinese name. The following are ACZONE ® Indicates the tra...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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