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Water-soluble dexamethasone acetate tablets and preparation method thereof

A dexamethasone acetate and water-soluble technology, applied in the field of water-soluble dexamethasone acetate tablets and their preparation, can solve problems such as insolubility in water, and achieve the effects of improving water solubility, simple processing and less investment in equipment

Active Publication Date: 2017-01-04
LINZHOU SINAGRI YINGTAI BIOLOGICAL PEPTIDES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Dexamethasone acetate is a kind of adrenal cortex hormone drug. Its anti-inflammatory, anti-allergic and anti-shock effects are more significant than prednisone, but it is insoluble in water. Currently, dexamethasone acetate tablets in the veterinary drug market are mainly water-insoluble , the breeding mode has changed from free-range farming to intensive farming. Therefore, the water solubility requirements of drugs in the market are constantly increasing

Method used

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  • Water-soluble dexamethasone acetate tablets and preparation method thereof
  • Water-soluble dexamethasone acetate tablets and preparation method thereof

Examples

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Effect test

Embodiment 1

[0013] A water-soluble dexamethasone acetate tablet, prepared from the following raw materials in parts by weight: 0.5-0.7 parts of dexamethasone acetate, 1-3 parts of PEG-6000, 80-90 parts of water-soluble starch, and 1-5 parts of sucrose , 1-5 parts of γ-cyclodextrin, 2-5 parts of sodium alginate, 2-5 parts of hydroxymethyl cellulose.

[0014] The preparation method of water-soluble dexamethasone acetate sheet as above may further comprise the steps:

[0015] (1) Preparation of dexamethasone acetate solid dispersion: Weigh dexamethasone acetate and PEG-6000 according to dexamethasone acetate: PEG-6000=(0.9-1.1): (0.9-1.1), mix well; mix the mixture Under the condition of 50°C-60°C, make a molten mixture, stir the molten mixture evenly, quickly place it under the low temperature condition of 0°C-4°C, cool it rapidly, and crush the cooled product at low temperature, pass through a 60-100 mesh sieve, that is Obtain the solid dispersion of dexamethasone acetate;

[0016] (2) M...

Embodiment 2

[0021] A water-soluble dexamethasone acetate tablet, prepared from the following raw materials in parts by weight: 0.6 parts of dexamethasone acetate, 2 parts of PEG-6000, 85 parts of water-soluble starch, 3 parts of sucrose, and 3 parts of γ-cyclodextrin , 3.5 parts of sodium alginate, 3.5 parts of hydroxymethyl cellulose.

[0022] The preparation method of water-soluble dexamethasone acetate sheet as above may further comprise the steps:

[0023] (1) Preparation of dexamethasone acetate solid dispersion: Weigh dexamethasone acetate and PEG-6000 according to dexamethasone acetate: PEG-6000=1:1, mix well, and prepare the mixture at 55°C Melt the mixture, stir the molten mixture evenly, quickly place it under the low temperature condition of 0°C, cool it rapidly, carry out the low-temperature crushing of the cooled product, and pass through an 80-mesh sieve to obtain the solid dispersion of dexamethasone acetate;

[0024] (2) Mix the solid dispersion of dexamethasone acetate w...

Embodiment 3

[0028] A water-soluble dexamethasone acetate tablet, prepared from the following raw materials in parts by weight: 0.6 parts of dexamethasone acetate, 3 parts of PEG-6000, 82 parts of water-soluble starch, 3 parts of sucrose, and 4 parts of γ-cyclodextrin , 3 parts of sodium alginate, 3.5 parts of hydroxymethyl cellulose.

[0029] The preparation method of water-soluble dexamethasone acetate sheet as above may further comprise the steps:

[0030] (1) Preparation of dexamethasone acetate solid dispersion: Weigh dexamethasone acetate and PEG-6000 according to dexamethasone acetate: PEG-6000=1:1.1, mix well, and prepare the mixture at 60°C Melt the mixture, stir the molten mixture evenly, quickly place it at a low temperature of 2°C, cool it rapidly, carry out low-temperature crushing of the cooled product, and pass through a 100-mesh sieve to obtain a solid dispersion of dexamethasone acetate;

[0031] (2) Mix the solid dispersion of dexamethasone acetate with water-soluble sta...

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Abstract

Water-soluble dexamethasone acetate tablets are prepared from raw materials in parts by weight as follows: 0.5-0.7 parts of dexamethasone acetate, 1-3 parts of PEG-6000, 80-90 parts of water-soluble starch, 1-5 parts of sucrose, 1-5 parts of gamma-cyclodextrin, 2-5 parts of sodium alginate and 2-5 parts of hydroxymethyl cellulose; preferably, the water-soluble dexamethasone acetate tablets are prepared from raw materials in parts by weight as follows: 0.6 parts of dexamethasone acetate, 2 parts of PEG-6000, 85 parts of water-soluble starch, 3.5 parts of sucrose, 3 parts of gamma-cyclodextrin, 3.5 parts of sodium alginate and 3.5 parts of hydroxymethyl cellulose. The water-soluble dexamethasone acetate tablets are simple to process, the equipment investment is low, insoluble raw materials are subjected to physicochemical treatment with a solid dispersion technology, and the water solubility of the dexamethasone acetate tablets is obviously improved on the premise that the chemical structure and the pharmacological action are unchanged, so that the product can meet water drinking use and adapt to intensive cultivation of the market.

Description

technical field [0001] The invention belongs to the technical field of veterinary drug processing, and in particular relates to a water-soluble dexamethasone acetate tablet and a preparation method thereof. Background technique [0002] Dexamethasone acetate is a kind of adrenal cortex hormone drug. Its anti-inflammatory, anti-allergic and anti-shock effects are more significant than prednisone, but it is insoluble in water. Currently, dexamethasone acetate tablets in the veterinary drug market are mainly water-insoluble , the breeding mode has changed from free-range farming to intensive farming. Therefore, the water-solubility requirements of drugs in the market are constantly increasing. Contents of the invention [0003] The purpose of the present invention is just to provide a kind of water-soluble dexamethasone acetate tablet and preparation method thereof. [0004] The purpose of the present invention is achieved in the following manner: [0005] A water-soluble d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/38A61K47/36A61K47/40A61K47/10A61K47/26A61K31/573A61P29/00A61P37/08A61P25/00
CPCA61K9/2018A61K9/2031A61K9/205A61K9/2054A61K9/2059A61K31/573
Inventor 郭文江吴保庆何涛刘扬科杨彩霞马振国
Owner LINZHOU SINAGRI YINGTAI BIOLOGICAL PEPTIDES CO LTD
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