Preparation technology and application of paeoniflorin wheat gliadin nanoparticles

Abstract

The invention discloses a preparation technology and application of paeoniflorin wheat gliadin nanoparticles. After gluten flour is subjected to degreasing, ethyl alcohol is added for extraction, an extracting solution is concentrated, and freeze drying is performed to obtain wheat gliadin; the wheat gliadin and paeoniflorin of the formula are weighed, ethyl alcohol is added for dissolution, the ethyl alcohol mixture solution is injected into a pluronic F68 or PVA-0486 solution, stirring is performed to obtain a colloid dispersion solution, and then freeze drying is performed to obtain paeoniflorin wheat gliadin nanoparticles. A nano-carrier is edible wheat gliadin and is free of toxicity, easy to obtain and low in production cost. The prepared paeoniflorin wheat gliadin nanoparticles can be independently used or be compatible with other medicines to prepare a preparation, absorption of paeoniflorin inside a human body is improved, the defect that the biological availability of paeoniflorin is poor is overcome, the medicine effect of paeoniflorin can be greatly improved, and the dosage is reduced.

Description

technical field [0001] The invention relates to a preparation method and application of paeoniflorin wheat prolamin nanoparticles. [0002] technical background [0003] Paeoniflorin is the main active ingredient of traditional Chinese medicine Radix Paeoniae Rubra and Radix Paeoniae Alba. It has biological activities such as anti-inflammatory, analgesic, and tranquilizing. Anti-inflammatory and immunomodulatory drugs for rheumatoid arthritis have positive curative effect and few adverse reactions in the treatment of RA, but the onset of effect is slow. Due to the strong hydrophilicity of paeoniflorin, weak lipophilicity and weak transmembrane absorption capacity, it is difficult to absorb paeoniflorin in the small intestine, and the bioavailability is low, only 3%-4%. Oral absorption of paeoniflorin is poor, which not only wastes a lot of drug resources, but also increases the dosage of drugs taken by patients. It is difficult for ordinary preparations to exert their good b...

AI Technical Summary

Problems solved by technology

[0003] Paeoniflorin is the main active ingredient of traditional Chinese medicine Radix Paeoniae Rubra and Radix Paeoniae Alba. It has biological activities such as anti-inflammatory, analgesic, and tranquilizing. Anti-inflammatory and immunomodulatory drugs for rheumatoid arthritis, which have a certain curative effect and few adverse reactions in the treatment of RA, but the onset of effect is slow

Due to the strong hydrophilicity of paeoniflorin, weak lipophilicity, and weak transmembrane absorption capacity, it is difficult to absorb paeoniflorin in the small intestine, and the bioavailability is low, only 3%-4%.

Oral absorption of paeoniflorin is poor, which not only wastes a lot of drug resources, but also increases the amount of drugs taken by patients. It is difficult for ordinary preparations to exert their good biological activity in the body through oral administration.