The application discloses a pH-induced photothermal enhancement type
cellulose hydrogel and a preparation method and application thereof. The pH-induced photothermal enhancement type
cellulose hydrogel is prepared by the following steps: preparing
cellulose nanocrystals with pH / near-
infrared light responsiveness by chemically
grafting intrinsic state
polyaniline on the surface of carboxylated
cellulose nanocrystals, preparing pH-responsive
drug-loaded
cellulose nanocrystals by chemically modifying anti-inflammatory drugs on the surface of
dialdehyde cellulose nanocrystals, and assembling the
drug-loaded micelles formed by
coating a
carbon monoxide donor,
manganese pentacarbonyl
bromide, with a temperature-sensitive
reagent, pluronic F68, into the pH-induced photothermal enhancement type cellulose hydrogel. The pH-induced photothermal enhancement type cellulose hydrogel has the pH-induced photothermal enhancement performance, can generate
carbon monoxide under
hydrogen peroxide stimulation, can controllably release anti-inflammatory drugs under pH stimulation, and can respond to
sol-gel transition above 33 DEG C.