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Wound dressing based on intelligent response type hydrogel-composite microspheres and preparation method

A technology of composite microspheres and wound dressings, applied in microcapsules, capsule delivery, pharmaceutical formulations, etc., can solve problems such as uncontrollable dosage of vascular endothelial growth factor, tumor recurrence hemangioma, etc., to avoid tumor recurrence, promote wound healing, avoid negative effects

Inactive Publication Date: 2021-08-13
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to solve the defects that the dosage of vascular endothelial growth factor cannot be controlled in the existing treatment plan for combined radiation and trauma, thus easily leading to tumor recurrence and hemangioma formation, and to provide an intelligent response based hydrogel-composite microscopic Ball wound dressing and preparation method

Method used

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  • Wound dressing based on intelligent response type hydrogel-composite microspheres and preparation method
  • Wound dressing based on intelligent response type hydrogel-composite microspheres and preparation method
  • Wound dressing based on intelligent response type hydrogel-composite microspheres and preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0031] 1) Mix 2g of Pluronic F68, 11g of Pluronic F127 with 87ml of deionized water; cool and stand overnight to obtain a smart responsive hydrogel;

[0032] 2) Add 0.8 μg of vascular endothelial growth factor VEGF to 20 ml of deionized aqueous solution containing 1% sodium alginate, and mix well; take 1.2 g of Span-80 and add it to 60 ml of liquid paraffin, mix at 800 r / min for 10 Minutes to form an oil phase; configure 8% CaCl 2 20ml solution; slowly add the deionized aqueous solution of sodium alginate into the oil phase stirred at 800r / min, stir for 10min, then drop 2ml of Tween-80 into the reaction system, and continue stirring for 5min; use a syringe to slowly add Slowly add 20ml of CaCl 2Solution, continue to stir at 800r / min for 10min; after the end, centrifuge the reaction system at 4000r / min for 10min, discard the supernatant; then use absolute ethanol and deionized water to wash four times alternately, and centrifuge at 4000r / min for 10min after each washing ;Fina...

Embodiment 2

[0036] 1) Mix 2g of Pluronic F68, 11g of Pluronic F127 with 87ml of deionized water; cool and stand overnight to obtain a smart responsive hydrogel;

[0037] 2) Add 0.8 μg of vascular endothelial growth factor VEGF to 20 ml of deionized aqueous solution containing 1% sodium alginate, and mix well; take 1.2 g of Span-80 and add it to 60 ml of liquid paraffin, mix at 800 r / min for 10 Minutes to form an oil phase; configure 8% CaCl 2 20ml solution; slowly add the deionized aqueous solution of sodium alginate into the oil phase stirred at 800r / min, stir for 10min, then drop 2ml of Tween-80 into the reaction system, and continue stirring for 5min; use a syringe to slowly add Slowly add 20ml of CaCl 2 Solution, continue to stir at 800r / min for 10min; after the end, centrifuge the reaction system at 4000r / min for 10min, discard the supernatant; then use absolute ethanol and deionized water to wash four times alternately, and centrifuge at 4000r / min for 10min after each washing ;Fin...

Embodiment 3

[0041] 1) Mix 2g of Pluronic F68, 11g of Pluronic F127 with 87ml of deionized water; cool and stand overnight to obtain a smart responsive hydrogel;

[0042] 2) Add 0.8 μg of vascular endothelial growth factor VEGF to 20 ml of deionized aqueous solution containing 1% sodium alginate, and mix well; take 1.2 g of Span-80 and add it to 60 ml of liquid paraffin, mix at 800 r / min for 10 Minutes to form an oil phase; configure 8% CaCl 2 20ml solution; slowly add the deionized aqueous solution of sodium alginate into the oil phase stirred at 800r / min, stir for 10min, then drop 2ml of Tween-80 into the reaction system, and continue stirring for 5min; use a syringe to slowly add Slowly add 20ml of CaCl 2 Solution, continue to stir at 800r / min for 10min; after the end, centrifuge the reaction system at 4000r / min for 10min, discard the supernatant; then use absolute ethanol and deionized water to wash four times alternately, and centrifuge at 4000r / min for 10min after each washing ;Fin...

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Abstract

The invention discloses a wound dressing based on intelligent response type hydrogel-composite microspheres. The wound dressing is hydrogel prepared from intelligent response type hydrogel and composite microspheres, and the mass ratio of the composite microspheres to the intelligent response type hydrogel is (1: 100)-(1: 200); the intelligent response type hydrogel is a composite aqueous solution containing pluronic F68 and pluronic F127; and the composite microsphere comprises a nano-scale sodium alginate single-layer microsphere loaded with a vascular endothelial growth factor (VEGF) and a nano-scale sodium alginate single-layer microsphere loaded with leptin (LP). The wound dressing based on the intelligent response type hydrogel-composite microspheres can be applied to treatment of combined wound, and two medicines with different effects are used, so that the prepared dressing has the dual effects of regulating and controlling the immunoreaction process and promoting angiogenesis.

Description

technical field [0001] The invention relates to the technical field of wound dressings, in particular to a wound dressing based on intelligent responsive hydrogel-composite microspheres and a preparation method thereof. Background technique [0002] Patients with postoperative radiotherapy for oral and maxillofacial malignancies often suffer from combined radiation and wound injury (CRWI), manifested as wound cell necrosis, vascular occlusion, uncontrollable inflammation, prone to infection, and protracted healing. It is a clinical problem that needs to be solved urgently . Therefore, how to protect the wound from being infected by foreign pollutants, and how to regulate the inflammatory reaction process of the wound through the rational use of corresponding drugs, promote the proliferation of vascular endothelial cells, thereby promoting the growth of granulation tissue, and promoting the re-epithelialization of wound surface tissue has become a radiation therapy. A key li...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0019A61L26/0023A61L26/0047A61L26/0066A61L26/008A61L2300/414A61L2300/412A61L2300/43A61L2300/622A61L2300/602C08L71/02C08L5/04C08L89/00
Inventor 刘志辉李凌锋王博蔚王碧舟翟建佳
Owner JILIN UNIV
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