Tumour interposition suppository norcantharidin-alginic acid/poly-acid anhydride control-release microsphere

A technology of demethylcantharidin and alginic acid, applied in medical science, surgery, etc., can solve the problems of large blood vessel irritation, toxic and side effects, unstable drug release, etc., and achieve stable drug release, simple preparation process, and ball formation good sex effect
CN101108262AInactive Publication Date: 2008-01-23SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE PUTUO DISTRICT CENT HOSPITAL
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE PUTUO DISTRICT CENT HOSPITAL
Publication Date
2008-01-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the pharmaceutical preparation filed and relates to a tumor interventional embolization agent, which takes norcantharidin as the active ingredient and biodegreadable material aliginate and polyanhydride as the accessories to establish emulsion-chemical crossline preparation method and prepare norcantharidin-alginic acid / poly acid anhydride micro-spheres. The norcantharidin micro spheres are applied for tumor interventional treatment through the hepatic artery. It can keep embolizing the tumor as long as one month and cause the tumor necrosis. At the same time, the microspheres can targetingly disperse in the tumor tissues to release the medicine slowly, prolong the active time of the medicine to the tumor tissues, increase partial medicine density and decrease the tumor toxicity. The invention has the advantages of targeting dispersed microspheres in the tumor tissues, long time for embolization, slow drug release, high anti-cancer effect and security.
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Description

technical field

[0001] The invention belongs to the field of pharmaceutical preparations, and relates to a tumor intervention embolization agent, in particular to a tumor intervention embolization agent norcantharidin-alginic acid / polyanhydride controlled-release microspheres. Background technique

[0002] Clinically, interventional therapy is the first choice for unresectable liver cancer. In 1950, klop pioneered hepatic arterial infusion chemotherapy, creating a precedent for interventional therapy for liver cancer. On this basis, Kato further developed transarterial chemoembolization (TACE), which pushed the curative effect of liver cancer to a new level. In China, interventional therapy has been widely used clinically since Lin Gui first carried out hepatic arterial embolization chemotherapy in 1984. Commonly used embolic agents in clinical interventional therapy are lipiodol and gelatin sponge, but medical practice shows that they have the following defects: lipiodol h...

Claims

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