Potassium dehydroandrographolide succinate/potassium dehydroandrographolide succinate liposome composition and production method thereof

A technology of Yanhuning and Chuanhuning, which is applied in the field of Yanhuning/Chuanhuning liposome combination drug and its preparation, can solve the problems of decreased curative effect and aggravated adverse reactions, so as to improve curative effect, reduce the number of administrations, and improve the therapeutic index Effect

Inactive Publication Date: 2007-02-07
刘祥华 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the process of preparation, storage, transportation and use, the effect of easy oxidation or photooxidation will cause the deterioration of the drug, which will lead to the aggravation of adverse reactions and the decline of curative effect

Method used

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  • Potassium dehydroandrographolide succinate/potassium dehydroandrographolide succinate liposome composition and production method thereof
  • Potassium dehydroandrographolide succinate/potassium dehydroandrographolide succinate liposome composition and production method thereof
  • Potassium dehydroandrographolide succinate/potassium dehydroandrographolide succinate liposome composition and production method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The formula that present embodiment adopts is as follows:

[0033] Phosphatidylethanolamine, dipalmitoylcholine,

[0034] Egg yolk lecithin weight ratio 1:1:2 mixture 3500g;

[0035] 1000g of a mixture of campesterol and cholesterol in a weight ratio of 1:1;

[0036] Vitamin E 50g;

[0037] 50g of any proportion mixture of polyethylene glycol 2000 and polyethylene glycol 6000;

[0038] Glycine and dextran 40 weight ratio 1: 1 mixture 160g;

[0039] 300g mixture of Yanhuning and Chuanhuning in any ratio.

[0040] The preparation method and steps are as follows:

[0041] 1. Dissolve synthetic phosphatidylethanolamine, dipalmitoylcholine, egg yolk lecithin mixture, campesterol, cholesterol mixture and vitamin E with ethanol or ethyl acetate;

[0042] 2. Transfer the solution prepared in step (1) to a rotary evaporator to remove ethanol at a temperature of 65±5°C, and vacuum-dry at room temperature for 5-10 hours to obtain a dry phospholipid film;

[0043] 3. Hydrate...

Embodiment 2

[0054] The formula that present embodiment adopts is as follows:

[0055] Phosphatidylethanolamine, dipalmitoylcholine,

[0056] 2000g of the mixture of egg yolk lecithin with a weight ratio of 1:1:6;

[0057] 1800g of a mixture of campesterol and cholesterol in a weight ratio of 1:4;

[0058] Vitamin E 40g;

[0059] 60g of a mixture of polyethylene glycol 2000 and polyethylene glycol 6000 in any proportion;

[0060] Glycine and dextran 40 weight ratio 1: 3 mixture 130g;

[0061] 700g mixture of Yanhuning and Chuanhuning in any ratio.

[0062] The preparation method and steps are as follows:

[0063] 1. Dissolve synthetic phosphatidylethanolamine, dipalmitoylcholine, egg yolk lecithin mixture, campesterol, cholesterol mixture and vitamin E with ethanol or ethyl acetate;

[0064] 2. Transfer the solution prepared in step (1) to a rotary evaporator to remove ethanol at a temperature of 65±5°C, and vacuum-dry at room temperature for 5-10 hours to obtain a dry phospholipid f...

Embodiment 3

[0078] The formula that present embodiment adopts is as follows:

[0079] Phosphatidylethanolamine, dipalmitoylcholine,

[0080] Egg yolk lecithin weight ratio 1:1:4 mixture 3500g;

[0081] 3200g of a mixture of campesterol and cholesterol in a weight ratio of 1:2.5;

[0082] Vitamin E 50g;

[0083] 80g of any proportion mixture of polyethylene glycol 2000 and polyethylene glycol 6000;

[0084] Glycine and dextran 40 weight ratio 1: 2 mixture 160g;

[0085] Any ratio mixture of Yanhuning and Chuanhuning 1000g.

[0086] The preparation method and steps are as follows:

[0087] 1. Dissolve synthetic phosphatidylethanolamine, dipalmitoylcholine, egg yolk lecithin mixture, campesterol, cholesterol mixture and vitamin E with ethyl acetate;

[0088] 2. Transfer the solution prepared in step (1) to a rotary evaporator to remove ethanol at a temperature of 65±5°C, and vacuum-dry at room temperature for 5-10 hours to obtain a dry phospholipid film;

[0089] 3. Hydrate the phosph...

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PUM

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Abstract

The invention discloses a potassium dehydroandrographolide succinate liposome combined drug and preparing method, which comprises the following parts: 1100-3500g phosphatidyl ethanolamine, dikitool bursine, egg lecithin at 1:1:2-6, 1000-3200g campesterol and cholesterol at 1:1-4; 30-50g vitamin E, 50-80g carbowax 2000 and carbowax 6000 at random proportion, 100-160g glycine and clockwise sugar 40 at 1: 1-3, 300-1000g potassium dehydroandrographolide succinate liposome.

Description

technical field [0001] The invention relates to a Yanhuning / Chuanhuning liposome combination medicine and a preparation method thereof. Background technique [0002] Yanhuning and Chuanhuning are metabolized into the same substance in the body, which are antiviral drugs and also have antipyretic and anti-inflammatory effects. No resistance to western medicine antibiotics. Moreover, Yanhuning / Chuanhuning is also an antiviral drug that can be applied to children. [0003] Adverse reactions of Yanhuning / Chuanhuning have been found in clinical application, ranging from skin rash in mild cases to dyspnea, edema, and even shock in severe cases. Adverse reactions such as digestive tract, blood system, and pyrogenic reactions were also found. [0004] The reason for these adverse reactions is the conjugation effect between the carbon-oxygen double bond and the carbon-carbon double bond in the chemical structure. In the process of preparation, storage, transportation and use, the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K31/365A61K31/355A61K47/24A61K47/34A61K47/28A61K47/18A61P31/12A61K47/10
Inventor 蔡海德
Owner 刘祥华
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