Antibacterial peptide preservative, antibacterial peptide preparation containing the same, and preparation method for the antibacterial peptide preparation

Abstract

The invention discloses an antibacterial peptide preservative, an antibacterial peptide preparation containing the same, and a preparation method for the antibacterial peptide preparation, and belongs to the field of pharmaceutical preparation. The antibacterial peptide preservative comprises a buffer, an amino acid, a stabilizing agent and an antioxidant. The antibacterial peptide preparation comprises the antibacterial peptide, a buffer, an amino acid, a stabilizing agent and an antioxidant. The preparation method for the antibacterial peptide preparation comprises: uniform mixing the antibacterial peptide, the buffer, the amino acid, the stabilizing agent, the antioxidant and water for injection, followed by adjusting pH value of the resulting mixture to 8.0-10.5, wherein the buffer is a Tris buffere, the amino acid is arginine, lysine or glutamic acid, the stabilizing agent is tween-80, Pluronic F68 or Pluronic F88, the antioxidant is methionine. According to the technical scheme provided by the embodiments of the present invention, the antibacterial peptide can be preserved for a long time without biological activity reducing, and preparation technology is simple so as to be suitable for an industrial production.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to an antimicrobial peptide preservation reagent, an antimicrobial peptide preparation containing the reagent and a preparation method for the preparation. Background technique [0002] Antibacterial peptide (ABP), also known as antimicrobial peptide (Antimicrobial peptide), antibiotic peptide (Antibiotics peptide), is a class of small molecular polypeptides with various biological activities induced by organisms, and is a key component of the host immune defense system. An important component, it has the advantages of broad-spectrum antibacterial, no drug resistance and toxic and side effects. At present, antimicrobial peptides have become a hot spot in the field of life science research. Scientists at home and abroad have isolated antimicrobial peptides from bacteria, fungi, amphibians, aquatic organisms, higher plants, mammals and even humans. At the same time, they hav...

AI Technical Summary

Problems solved by technology

Some of these changes are known to result in decreased or no drug activity

In particular, these degradation products may have potential adverse side effects

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