Nimodipine long-acting oral suspension liquid and preparation method thereof

Abstract

The invention discloses nimodipine long-acting oral suspension liquid and a preparation method thereof. The nimodipine long-acting oral suspension liquid is prepared from the following components in parts by weight: 0.1 to 0.3 part of nimodipine nano-particle, 0.1 to 0.3 part of nimodipine, 0.1 to 2 parts of sweetening agent, 1 to 5 parts of pH buffering agent, 0.1 to 2 parts of preservative and 90 to 100 parts of solvent. A carrier material of the nimodipine nano-particle is a combinant of polylactic acid-hydroxyacetic acid copolymer and pluronic F68, and the pluronic F68 is 5 to 40 percent by mass of the carrier material. The nimodipine long-acting oral suspension liquid disclosed by the invention is convenient to orally take and has a good taste; a part of medicines exists in a free state, so that absorption speed can be accelerated and an effect takes quickly; a part of medicines are carried in the polylactic acid-hydroxyacetic acid copolymer and pluronic F68 nano-particles, so that a first pass effect can be reduced, a medicine utilization ratio is high, the drug load of the nano-particles is large, an entrapment ratio is high, release is slow, the acting time is long, the administration frequency is reduced, the defect of existing marketed dosage forms is overcome; the preparation method has the advantages of good reproducibility, good repeatability, and easiness for being strongly implemented and popularized on the industry.

Description

technical field [0001] The invention relates to a nimodipine oral long-acting suspension and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Subarachnoid hemorrhage (SAH) is a very serious common disease, mainly caused by rupture of blood vessels at the base of the brain or on the surface of the brain, and blood flowing into the subarachnoid space. The main complications are cerebral vasospasm, cerebral hemorrhage Water, rebleeding, etc. The World Health Organization survey shows that the incidence rate in China is about 2.0 / 100,000 person-years, and it is also reported that it is 6-20 / 100,000 person-years per year. Migraine (migraine) is the most common type of primary headache clinically, clinically characterized by paroxysmal moderate to severe, throbbing headache as the main manifestation, most of the onsets are in children and adolescence, and the incidence peaks in young and middle-aged adults. [0003] Nimodi...

AI Technical Summary

Problems solved by technology

For patients, especially children, the oral compliance of ordinary tablets is poor, the drug is difficult to dissolve in water, and the dissolution rate is slow, so the onset of action is slow, and the action time is short, and the toxicity is strong after taking multiple times. Low; and the commercially available nimodipine injection has no definite research data for children, and its effectiveness and safety are not clear

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