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Anti-parasitic medicine composition and application

An anti-parasitic and composition technology, applied in the field of anti-parasitic pharmaceutical compositions, can solve the problem of not involving L-praziquantel compound drug combination or preparation, and not finding the combination of L-praziquantel and triphenyldiamididine liver fluke. problems such as public literature reports and other issues, to achieve the effect of improving the prevention or treatment effect, reducing the dosage and cost of the drug, and making the drug application simple

Inactive Publication Date: 2017-01-25
TONGLI BIOMEDICAL
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There are many patented inventions similar to this, but so far, there are still no patents or literature reports related to the compound drug combination or preparation of L-praziquantel, and no information about the therapeutic effect of L-praziquantel and triphenylbisamidine has been found. Published literature reports on combined use in liver fluke

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  • Anti-parasitic medicine composition and application
  • Anti-parasitic medicine composition and application
  • Anti-parasitic medicine composition and application

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Embodiment Construction

[0040] The inventor obtained high-quality L-praziquantel through a process independently developed, and conducted sufficient research on its physical and chemical properties, biological activities, etc., and found that L-praziquantel is more suitable than traditional racemic praziquantel. As one of the active anti-insect components of the compound drug combination.

[0041]The invention mainly relates to a pharmaceutical composition containing L-praziquantel and triphenylmidine, which is used for combined treatment of Clonorchis sinensis and / or Civet Opisthorchis sinensis infection. Through in vivo and in vitro pharmacodynamic studies, we found that L-praziquantel and triphenylmidine have obvious synergistic effects when they are used in combination to treat Clonorchis sinensis or Opistorchis sinensis infection.

[0042] When L-praziquantel is used in combination with triphenylbisamidine, it shows obvious synergistic effect both in vivo and in vitro, which is mainly reflected ...

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Abstract

The invention relates to an anti-parasitic medicine composition and application. The composition comprises an anti-parasitic active component, wherein the anti-parasitic active component comprises left-handed praziquantel, tribendimidine and / or a tribendimidine in vivo metabolite. By mixed use of the left-handed praziquantel, the tribendimidine and / or the tribendimidine in vivo metabolite, the anti-parasitic medicine composition has the synergistic interaction effect, can effectively enhance the prevention or treatment effect and reduce the medicine use amount and the cost, and enables medicine application to be simpler. Compared with a single anti-parasitic active component medicine, the composition expands the range of an anti-parasitic spectrum, and is suitable for clonorchis sinensis and / or opisthorchis viverrini infection of human and animals. Furthermore, the composition is high in medicine compliance, high in safety and high in economy.

Description

technical field [0001] The invention relates to an antiparasitic pharmaceutical composition for preventing and / or treating Clonorchis sinensis and / or Opisthorchis sinensis infection and application thereof. Background technique [0002] Food-borne trematodiases (food-borne trematodiases) is a parasitic disease infected by eating raw or half-cooked food containing trematodes in the infective stage. Currently, at least 56 million people worldwide suffer from one or more foodborne trematode infections, mainly through eating raw fish, crustaceans or vegetables with parasite larvae, and foodborne trematode infections occur in East Asia and South America most common. The main foodborne flukes and their epidemiological characteristics are shown in the following table: [0003] [0004] Liver fluke disease is a type of food-borne fluke disease that occurs when people ingest secondary intermediate hosts infected with clonorchis or civets Opistorchis sinensis larvae. Clonorchias...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4985A61K31/155A61P33/10A61P33/00
CPCA61K31/155A61K31/4985A61K2300/00
Inventor 施俊巍钱明心
Owner TONGLI BIOMEDICAL
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