Method for producing pharmaceutical grade sodium dehydroacetate by membrane filtration

A technology of sodium dehydroacetate and dehydroacetic acid, applied in the direction of organic chemistry and the like, can solve the problems of high investment, high production cost, large plant area, etc., and achieves the effects of good filtering effect, easy purification and cost saving.

Inactive Publication Date: 2017-01-25
NANTONG ALCHEMY BIOTECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The object of the present invention is to provide a kind of method that membrane filtration manufactures pharmaceutical grade sodium dehydroacetate, to solve the traditional preparation method that proposes in the above-mentioned background technology, production cost is high, and investment is high, and occupation workshop area is big, and labor is many, and in the production process The problem of waste water and waste residue

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  • Method for producing pharmaceutical grade sodium dehydroacetate by membrane filtration

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Embodiment 1

[0024] see figure 1 , the present invention provides a kind of technical scheme: a kind of method of membrane filtration manufactures pharmaceutical grade sodium dehydroacetate, the steps of the method for this membrane filtration manufacture pharmaceutical grade sodium dehydroacetate are as follows:

[0025] S1: Preparation of dehydroacetic acid: material: ethyl acetoacetate, put ethyl acetoacetate in a flask, add water to the flask, stir until ethyl acetoacetate is completely dissolved in water, heat the flask on an alcohol lamp, To obtain dehydroacetic acid, put 5 parts of ethyl acetoacetate in a flask, add 100 parts of water to the flask, place the flask on an alcohol lamp and heat for 2-2.5 hours to obtain solid dehydroacetic acid;

[0026] S2: Purify the crude product of dehydroacetic acid: put the dehydroacetic acid produced in step S1 in a clean beaker, add an inert solvent into the beaker, heat and stir the beaker, and filter the solution in the beaker to remove impur...

Embodiment 2

[0034] A method for membrane filtration to manufacture pharmaceutical grade sodium dehydroacetate, the membrane filtration method for manufacturing pharmaceutical grade sodium dehydroacetate is as follows:

[0035] S1: Preparation of dehydroacetic acid: material: ethyl acetoacetate, put ethyl acetoacetate in a flask, add water to the flask, stir until ethyl acetoacetate is completely dissolved in water, heat the flask on an alcohol lamp, To obtain dehydroacetic acid, the specific steps for preparing dehydroacetic acid are: put 5 parts of ethyl acetoacetate in a flask, add 100 parts of water to the flask, place the flask on an alcohol lamp and heat for 2.25 hours to obtain Solid dehydroacetic acid;

[0036]S2: Purify the crude product of dehydroacetic acid: put the dehydroacetic acid produced in step S1 in a clean beaker, add an inert solvent into the beaker, heat and stir the beaker, and filter the solution in the beaker to remove impurities using a filter sieve Finally, the ...

Embodiment 3

[0044] A method for membrane filtration to manufacture pharmaceutical grade sodium dehydroacetate, the membrane filtration method for manufacturing pharmaceutical grade sodium dehydroacetate is as follows:

[0045] S1: Preparation of dehydroacetic acid: material: ethyl acetoacetate, put ethyl acetoacetate in a flask, add water to the flask, stir until ethyl acetoacetate is completely dissolved in water, heat the flask on an alcohol lamp, To obtain dehydroacetic acid, the specific steps for preparing dehydroacetic acid are: put 5 parts of ethyl acetoacetate in a flask, add 100 parts of water to the flask, place the flask on an alcohol lamp and heat for 2.5 hours to obtain Solid dehydroacetic acid;

[0046] S2: Purify the crude product of dehydroacetic acid: put the dehydroacetic acid produced in step S1 in a clean beaker, add an inert solvent into the beaker, heat and stir the beaker, and filter the solution in the beaker to remove impurities using a filter sieve Finally, the ...

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Abstract

The invention discloses a method for producing a pharmaceutical grade sodium dehydroacetate by membrane filtration in the technical field of sodium dehydroacetate preparation. The method for producing the pharmaceutical grade sodium dehydroacetate by filtration is as follows: S1: preparing dehydroacetic acid; S2: purifying crude product of dehydroacetic acid; S3: preparing sodium dehydroacetate; S4: carrying out secondary filtration, and purification; S5: carrying out distillation and crystallization; S6: carrying out dehydration; S7: preparing medical sodium dehydroacetate; S8: covering half, saving the method for producing pharmaceutical grade sodium dehydroacetate by membrane filtration, dissolving the prepared dehydroacetic acid for the convenient of purification of dehydroacetic acid. Activated carbon is used to adsorb small particles in the solution to improve purity. Because an activated carbon adsorbing block will not produce much dust, the drawbacks of activated carbon powder are avoided. By using the ultrafiltration membrane to filter the solution, the filtration effect is better, and the purity of the preparation is improved.

Description

technical field [0001] The invention relates to the technical field of preparation methods of sodium dehydroacetate, in particular to a method for manufacturing pharmaceutical grade sodium dehydroacetate by membrane filtration. Background technique [0002] Sodium dehydroacetate has a strong antibacterial effect on yeast, spoilage bacteria and mold in food, and is widely used in antisepsis and preservation of meat, fish, vegetables, fruits, beverages, pastries, etc. Novel broad-spectrum bacteriostatic agent, existing production sodium dehydroacetate process mainly has following shortcoming: the one, produce waste water, waste residue in the production process; The 2nd, waste gas can be produced if organic solvent is made reaction medium, even have safety problem; The 3rd is In the synthesis process, a large amount of energy and relatively strict reaction conditions are required, the production cost is high, the investment is high, the plant area is large, and the labor is la...

Claims

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Application Information

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IPC IPC(8): C07D309/36
CPCC07D309/36
Inventor 许卫东卞杨伟
Owner NANTONG ALCHEMY BIOTECH DEV
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