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Six Divine Comedy and its preparation method

A technology of Liushenqu and Aspergillus, which is applied in the preparation of Liushenqu and the multi-strain fermentation process to prepare Liushenqu, which can solve the problems that the metabolites of the metabolism of a single strain cannot be completely replaced and affect the therapeutic effect of Liushenqu, so as to achieve easy control and detection, good digestion and accumulation, and good effects

Active Publication Date: 2019-11-26
BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the inventors of the present application believe that despite the above-mentioned advantages in single-strain fermentation, the traditional natural fermentation method of Liushenqu is the result of the joint action of multiple microorganisms, and the metabolism and metabolites of a single strain cannot completely replace the multiple microorganisms in the traditional fermentation system. The role of bacterial species, which may affect the therapeutic effect of Liushenqu

Method used

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  • Six Divine Comedy and its preparation method
  • Six Divine Comedy and its preparation method
  • Six Divine Comedy and its preparation method

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preparation example Construction

[0026]

[0027] In the present invention, the Aspergillus sydowii has a Latin name of Aspergillus sydowii, which can be purchased from the market, or can be prepared according to methods recorded in existing literature. The Bacillus subtilis, whose Latin name is Bacillus subtilis, can be purchased from the market, or can be prepared according to methods recorded in existing literature.

[0028] The preparation method of the present invention includes a fermentation step and a drying step.

[0029] The fermentation step of the present invention is as follows: the preparation method includes a fermentation step: inoculating the seed liquid of Aspergillus seburi and Bacillus subtilis into the matrix of Liushenqu; the concentration of the seed liquid of Aspergillus seburi is 1-20 Silk ball / ml, the concentration of the seed liquid of described Bacillus subtilis is 10 8 ~10 10 CFU / ml, and the bacterial liquid volume ratio of the Aspergillus sayi to the Bacillus subtilis is 10-1:...

Embodiment 1

[0046] The preparation method of Liushenqu A:

[0047] Mix 2.4 parts by weight of Chixiaodou, 2.4 parts by weight of bitter almonds, 1.4 parts by weight of Artemisia annua, 1.4 parts by weight of Cocklebur, 1.4 parts by weight of Polygonum caperica, 40 parts by weight of flour and 20 parts by weight of wheat bran after crushing and passing through a 40-mesh sieve Evenly, add 26 parts by weight of distilled water, sterilize at 121°C for 25 minutes, and cool to obtain Liushenqu matrix.

[0048] Activate the slant of Aspergillus serburi twice, inoculate it in PDA liquid medium, at 28°C, the rotation speed is 160r min -1 Vibrating culture under the conditions for 3 days to obtain the Aspergillus sebui seed liquid, the concentration of the Aspergillus sebui seed liquid is about 5-6 mycelial balls / ml. Activate the slant of Bacillus subtilis twice, inoculate it in beef extract peptone liquid medium, at 30°C, with a rotation speed of 160r min -1 Shaking culture under the condition f...

Embodiment 2

[0051] The preparation method of Liushenqu B:

[0052] Mix 8 parts by weight of Chixiaodou, 8 parts by weight of bitter almonds, 5 parts by weight of Artemisia annua, 5 parts by weight of Cocklebur, 5 parts by weight of Polygonum capsicum, and 100 parts by weight of flour after crushing and passing through a 40-mesh sieve, and add 50 parts by weight Distilled water, sterilized at 121°C for 25 minutes, cooled to obtain Liushenqu matrix.

[0053] Activate the slant of Aspergillus serburi twice, inoculate it in PDA liquid medium, at 30°C, the rotation speed is 200r·min -1 Vibrating cultivation under the conditions for 2 days to obtain the Aspergillus seburi seed liquid, the concentration of the Aspergillus seburi seed liquid is 6-7 mycelium balls / ml. Activate the slant of Bacillus subtilis once, inoculate it in the beef extract peptone liquid medium, at 28°C, the rotation speed is 150r min -1 Shaking culture under condition for 4 days, obtain Bacillus subtilis seed liquid, the ...

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Abstract

The invention discloses medicated leaven and a preparation method thereof. The preparation method of the medicated leaven comprises the following fermentation steps: inoculating aspergillus sydowii seed liquid and bacillus subtilis seed liquid into a medicated leaven matrix, wherein the concentration of the aspergillus sydowii seed liquid is 1 to 20 mycelium pellets / ml, the concentration of the bacillus subtilis seed liquid is 10<8>-10<10>CFU / ml, and the bacterial liquid volume ratio of aspergillus sydowii and bacillus subtilis is (10 to 1) : (1 to 10). The medicated leaven prepared by the preparation method is better in the efficacy of strengthening spleen and stomach and helping digestion to disperse accumulations, liable in control and detection in the fermentation process, high in quality of a product and better in stability.

Description

technical field [0001] The invention relates to a preparation method of Liushenqu, in particular to a method for preparing Liushenqu by a multi-strain fermentation process, and to Liushenqu prepared by the method. Background technique [0002] Six Divine Comedy, also known as Divine Comedy, is a koji made by mixing traditional Chinese medicines such as bitter almonds, red beans, artemisia annua, cocklebur, and Polygonum chinensis into flour or wheat bran. , a wide range of clinical applications. [0003] At present, the production of Liushenqu in different places is based on different standards, and there are differences in raw materials, raw material ratios, addition methods, and production processes, and the quality evaluation standards for Liushenqu are not yet perfect. Due to the natural fermentation method used in the traditional production process of Liu Shenqu, the quality of products in different production areas or even different batches of the same production area...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/899A61P1/04A61P1/00A61P1/14
CPCA61K36/28A61K36/282A61K36/48A61K36/704A61K36/736A61K36/899A61K2236/19A61K2300/00Y02A50/30
Inventor 史新元戚岑聪马维维
Owner BEIJING UNIV OF CHINESE MEDICINE