Device for predicting thermostabilized mutants of membrane proteins, method for predicting thermostabilized mutants, and program
A technology for predicting devices and proteins, applied in proteomics, peptide preparation methods, chemical instruments and methods, etc., can solve the problems of difficult mass production, difficult crystallization, low thermal stability, etc., and achieve the best structure. the effect of
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[0244] In addition, refer to figure 1 ,as well as Figure 33 to Figure 47 , an example of the thermostable mutant prediction device 100 according to this embodiment will be described. Figure 33 It is a flowchart showing an example of processing executed by the thermostable mutant prediction device 100 .
[0245] Such as Figure 33 As shown, first, the mutation introducing unit 102a generates the amino acid sequence of the mutant Mt by introducing amino acid mutations into the amino acid sequence of the membrane protein wild-type Wt stored in the sequence file 106b (step SB-1). For example, the mutation introducing unit 102a may generate a mutant Mt into which an amino acid mutation such as deletion of one amino acid, substitution of one amino acid, or addition of one amino acid has been introduced.
[0246] Thereafter, the calculation unit 102b calculates, for the membrane protein wild-type Wt and each mutant Mt, the change in entropy of solvation from the formation of the...
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