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Compound lutein solid preparation for relieving asthenopia and improving vision function and preparation method thereof

A technology of compound lutein and solid preparations, which is applied in the direction of medical preparations containing active ingredients, sensory diseases, pharmaceutical formulas, etc., and can solve problems such as poor bioavailability, undisclosed or taught lutein bioavailability, etc. Achieve the effect of improving photophobia, improving the persistence of clear vision, improving visual fatigue and visual function

Inactive Publication Date: 2017-02-22
北京瑞济善健康科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this patent document, if the ratio of water and organic solvent is not selected properly, it is easy to produce high aggregates or ring aggregates
Such high aggregates or ring aggregates show poor bioavailability in feed
At the same time, this patent document does not disclose or teach how to better improve the bioavailability of lutein in eye care and therapeutic preparations

Method used

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  • Compound lutein solid preparation for relieving asthenopia and improving vision function and preparation method thereof
  • Compound lutein solid preparation for relieving asthenopia and improving vision function and preparation method thereof
  • Compound lutein solid preparation for relieving asthenopia and improving vision function and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Example 1 of the present invention is used to relieve visual fatigue compound lutein solid preparation, the specific preparation steps are as follows:

[0068] (1) Pulverize and pass through a 100-mesh sieve the following raw materials in parts by weight: 3 parts of lutein, 35 parts of vitamin A, 40 parts of vitamin C, 20 parts of vitamin E, 18 parts of vitamin B, 2 parts of copper oxide, and 6 parts of zinc sulfate ;

[0069] (2) mixing each raw material obtained in step (1) uniformly to obtain a premix;

[0070] (3) Put 110 parts of purified water and 18 parts of glycerin in a plastic tank, heat to 60°C, put 11 parts of gelatin, 6 parts of titanium dioxide, and 4 parts of lemon yellow into the plastic tank, and continue heating to 80°C , stir while heating to dissolve the gelatin completely, keep it warm for 1 hour, let it stand until the foam floats up, vacuumize and defoam, pass through a 100-mesh sieve to obtain glue, keep warm for later use;

[0071] (4) Take 11...

Embodiment 2

[0076] Example 2 of the present invention is used to relieve visual fatigue compound lutein solid preparation, the specific preparation steps are as follows:

[0077] (1) Pulverize and pass through a 100-mesh sieve in the following parts by weight: 10 parts of lutein, 40 parts of vitamin A, 45 parts of vitamin C, 35 parts of vitamin E, 120 parts of vitamin B, 3 parts of copper sulfate, and 7 parts of zinc oxide ;

[0078] (2) mixing each raw material obtained in step (1) uniformly to obtain a premix;

[0079] (3) Put 120 parts of purified water and 20 parts of glycerin in a plastic tank, heat to 60°C, put 12 parts of gelatin, 8 parts of titanium dioxide, and 5 parts of tartrazine into the plastic tank, and continue heating to 80°C , stir while heating to dissolve the gelatin completely, keep it warm for 2 hours, let it stand until the foam floats up, vacuumize and defoam, pass through a 100-mesh sieve to obtain glue, keep it warm for later use;

[0080] (4) Take 12 parts of ...

Embodiment 3

[0085] Example 3 of the present invention is used to relieve visual fatigue compound lutein solid preparation, the specific preparation steps are as follows:

[0086] (1) Pulverize the raw materials in the following parts by weight and pass through a 100-mesh sieve: 8 parts of lutein, 40 parts of vitamin A, 30 parts of vitamin C, 45 parts of vitamin E, 125 parts of vitamin B, 4 parts of copper oxide, and 10 parts of zinc oxide ;

[0087] (2) mixing each raw material obtained in step (1) uniformly to obtain a premix;

[0088] (3) Put 106 parts of purified water and 15 parts of glycerin in a plastic tank, heat to 60°C, put 10 parts of gelatin, 5 parts of titanium dioxide, and 3 parts of tartrazine into the plastic tank, and continue heating to 80°C , stir while heating to dissolve the gelatin completely, keep it warm for 1 hour, let it stand until the foam floats up, vacuumize and defoam, pass through a 100-mesh sieve to obtain glue, keep warm for later use;

[0089] (4) Take ...

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Abstract

The invention discloses a compound lutein solid preparation for relieving asthenopia and improving a vision function. The compound lutein solid preparation is characterized by comprising the following raw materials: 1-10 parts of lutein, 20-50 parts of vitamin A, 20-50 parts of vitamin C, 20-50 parts of vitamin E, 5-30 parts of vitamin B1, 1-5 parts of natural copper and 5-10 parts of natural zinc. Besides, the invention also discloses a preparation method for the compound lutein solid preparation. The compound lutein solid preparation disclosed by the invention can obviously relieve asthenopia and improve the vision function of the patient, and meanwhile can greatly increase the photopic vision persistence, and the total efficiency is as high as above 60%; and meanwhile, the symptoms of the patient, including blurred vision, dry eyes, eye distension, sore eyes, photaesthesia, and the like, can be greatly relieved.

Description

technical field [0001] The invention belongs to the technical field of ophthalmology, and relates to an ophthalmic health care and treatment preparation, in particular to a compound lutein solid preparation for alleviating visual fatigue and improving visual function and a preparation method thereof. [0002] technical background [0003] In modern society, due to the popularization of TV and computer and the increase of work and life pressure, eye fatigue and related eye diseases are increasing day by day. Eye fatigue, also known as eye fatigue, is a series of eye discomfort symptoms caused by excessive eye use (including: reading documents, operating computers, surfing the Internet, watching TV, driving, etc.) and environmental factors (dry climate, air-conditioned environment, etc.) , mainly manifested as dry eyes, foreign body sensation, blurred vision, and sore eyes. For the visually impaired, the above-mentioned discomfort symptoms are particularly obvious, affecting t...

Claims

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Application Information

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IPC IPC(8): A61K33/30A61K9/48A61P27/02A61K31/047A61K31/07A61K31/375A61K31/355A61K31/51A61K33/26
CPCA61K31/047A61K9/4858A61K31/07A61K31/355A61K31/375A61K31/51A61K33/26A61K33/30A61K2300/00
Inventor 张青贺付俊昌
Owner 北京瑞济善健康科技有限公司
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