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Bismuth-containing solid dispersion for treating peptic ulcer

A solid dispersion, peptic ulcer technology, applied to the digestive system, medical preparations containing active ingredients, plant/algae/fungus/moss ingredients, etc. To achieve the effect of improved anti-ulcer activity, less side effects, and ideal analgesic effect

Inactive Publication Date: 2017-03-08
门源县雪草木生物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned prescriptions have more medicinal flavors, a larger amount of medicinal materials, and higher costs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1 Preparation of the pharmaceutical composition of the present invention

[0022] Take 0.3g bismuth potassium citrate, 2g Zushima, 10g Atractylodes macrocephala, 3g Ganoderma lucidum, 8g Codonopsis 8g, 8g Radix Pseudostellariae, 8g capillary, 10g dandelion, 5g bellflower, 5g patchouli, 4g nutmeg. After drying, pulverize to 250 meshes, and mix uniformly to obtain raw drug powder.

[0023] Take raw drug powder: polyethylene glycol-6000=1:3w / w, mix well, heat until polyethylene glycol-6000 is in a molten state, stir, immediately place in 0°C environment and quench until solidified, crush to obtain Solid dispersion.

[0024] Typical case 1

[0025] Zhang, female, 36 years old, experienced epigastric discomfort after eating, accompanied by belching, pantothenic acid, and occasional vomiting. The symptoms had lasted for 3 months, and her weight dropped significantly. After diagnosis, it was confirmed as chronic superficial gastritis.

[0026] After taking Examp...

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Abstract

The invention provides a solid dispersion for treating peptic ulcer, which is prepared from raw material medicine powder: polyethylene glycol-6000=(1 to 2):(3 to 5)w / w, wherein the raw material medicine powder is prepared by grinding the following raw material medicines into 200 to 500 meshes according to a weight proportion: 0.2 to 0.4 part of bismuth potassium citrate, 1 to 3 parts of cortex daphnes, 7 to 13 parts of bighead atractylodes rhizome, 2 to 3 parts of fruiting body of ganoderma, 5 to 10 parts of radix codonopsis, 5 to 10 parts of radix pseudostellariae, 5 to 10 parts of herba artemisiae capillariae, 5 to 10 parts of herba taraxaci, 3 to 7 parts of radix platycodonis, 3 to 7 parts of herba pogostemonis and 2 to 4 parts of kernel of netmeg. According to the solid dispersion, the raw material medicine powder is prepared into the solid dispersion, so that bioavailability of a medicament is improved, and the anti-ulcerogenic activity is obviously improved.

Description

technical field [0001] The invention relates to a solid dispersion for treating peptic ulcer. Background technique [0002] Gastric and duodenal ulcers refer to localized round or oval full-thickness defects of gastric and duodenal mucosa, the muscularis mucosae is penetrated, and fibrous scars inevitably remain after healing, with a layer of epithelium on the surface Overlying, the muscularis mucosa cannot regenerate. The etiology can be summed up as the self-digestion of gastric mucosa by gastric acid and pepsin or the destruction of gastric mucosal barrier due to various reasons. In recent years, it has been considered that the formation of ulcers has an important relationship with Helicobacter pylori infection in the stomach. [0003] Chronic superficial gastritis is a disease of chronic superficial inflammation of the gastric mucosa. It is a common disease of the digestive system and belongs to chronic gastritis. It can be caused by alcoholism, strong coffee, bile re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/83A61K9/14A61K47/10A61P1/04A61K31/194
CPCA61K31/194A61K9/146A61K36/074A61K36/185A61K36/28A61K36/284A61K36/288A61K36/344A61K36/346A61K36/36A61K36/532A61K36/83A61K2300/00
Inventor 徐继锋许婧
Owner 门源县雪草木生物药业有限公司
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