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Composite dressing applied to wound and preparation method thereof

A wound and compound technology, applied in the fields of application, chemical instruments and methods, and pharmaceutical formulations, can solve problems such as pain, re-cracking, and easily involved wounds, and achieve the effects of accelerating wound healing, promoting regeneration, and having no toxic side effects

Inactive Publication Date: 2017-03-08
北京东方艾美生物技术股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are various types of drugs for treating trauma or hemostasis, a considerable part of the hemostatic drugs need to be taken orally to complete a series of complex physiological processes in the body, instead of simply acting directly on the blood vessels of the wound to achieve hemostasis. Purpose
Although some medicines can be directly applied to the wound, the medicine is dry, and the wound is easily involved when moving the wound, causing pain or cracking again, and because the medicine cannot be absorbed by the skin, it is necessary to clean up the medicine left on the wound after use or when changing the dressing foam or debris, causing distress to the patient and possibly delaying wound healing

Method used

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  • Composite dressing applied to wound and preparation method thereof
  • Composite dressing applied to wound and preparation method thereof
  • Composite dressing applied to wound and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0049] A composite dressing applied to wounds. The dressing is composed of hair keratin and traditional Chinese medicine ingredients. The traditional Chinese medicine ingredients include Panax notoginseng, Chonglou, Dustin, borneol and musk.

[0050] The weight ratio of hair keratin and Chinese medicine components is 1-3:3-1, preferably 1:1-2, for example 1:1.

[0051] The parts by weight of the various ingredients in the Chinese medicine ingredients can be: ① 20 parts of Panax notoginseng, 25 parts of Chonglou, 10 parts of Dingzi, 20 parts of Borneolum and 0.001 part of musk; ② 40 parts of Panax notoginseng, 10 parts of Chonglou, 20 parts of stator, 40 parts of borneol and 0.8 part of musk; ③ 30 parts of Sanqi, 18 parts of Chonglou, 15 parts of independent stator, 30 parts of borneol and 0.1 part of musk; ④ 25 parts of Panax notoginseng, 12 parts of Chonglou, 18 of independent stator 35 parts of borneol and 0.03 part of musk; ⑤ 33 parts of Panax notoginseng, 23 parts of Chong...

Embodiment 2

[0056] A kind of preparation method of the compound type dressing that root is applied to wound surface, the concrete method of this method is as follows:

[0057] (1) Preparation of hair keratin:

[0058] S1: Degreasing: Weigh 5g of hair and put it in a 1000ml beaker. Add 99.7% absolute ethanol to soak for 30 minutes, stir once with a glass rod every 5 minutes, and rinse with running water;

[0059] S2: Softening: Place the washed hair in a solution of ≥10% sodium hypochlorite 10ml and distilled water 90ml, soak at room temperature for 30 minutes, stir with a glass rod once every 5 minutes, and rinse with running water;

[0060] S3: decolorization: by the weight of 5g hair, take by weighing 99% sodium pyrophosphate (Na 4 P 2 o 7 )4g, 99.5% potassium persulfate (K 2 S 2 o 8 ) 1.5g, 30% hydrogen peroxide (H 2 o 2 ) 80ml, 25% concentrated ammonia water 27.5ml, distilled water 400ml, make a decolorization solution, put the softened hair in this solution, put it in a cons...

Embodiment 3

[0076] The gelling among the present invention gets the preparation method of hair keratin and can be any one of following two kinds of methods:

[0077] 1. Weigh the high-purity granular hair keratin 50mg obtained in the present invention (for example, Example 2) and add 5ml of water, mix thoroughly, place in an incubator and incubate for 2-3 hours until a relatively uniform Color and character; Sterilize, obtain gelled hair keratin, its concentration is 1%.

[0078] 2. S1: Weigh 10g of wool or human hair, put it into a three-neck flask containing a mixed solution of 180ml of absolute ethanol and 20ml of distilled water, heat it for 15 minutes and then raise the temperature to 75°C, and the solution starts to reflux; then, drip while refluxing Add 2ml of NaOH solution until the pH value of the oxidized keratin is 7, the reflux and dropwise addition are completed at the same time, and the time lasts for 90 minutes; after the dropwise addition and reflux are completed, continue...

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Abstract

The invention relates to a composite dressing applied to a wound and a preparation method thereof. The dressing comprises hair keratin and a traditional Chinese medicine component, wherein hair comprises any one selected from a group consisting of human hair and animal wool, and the traditional Chinese medicine component comprises pseudo-ginseng, Rhizoma Paridis, Psammosilene tunicoides, borneol and musk. The preparation method comprises the following steps: preparation of the hair keratin; preparation of the traditional Chinese medicine component; and preparation of the dressing. According to the invention, traditional Chinese medicine is combined with a biomaterial, and hair keratin gel and the like are used as a carrier for wound healing via the traditional Chinese medicine component, so a wound covering material with the properties of a biological dressing can be formed; the prepared composite dressing is a wound covering material with excellent effect; and along with slow healing of a wound and skin growth, the composite dressing provides a wound healing environment for promotion of skin regeneration.

Description

technical field [0001] The invention relates to a dressing, in particular to a composite dressing applied to wounds and a preparation method thereof. Background technique [0002] Human and animal trauma can be seen everywhere, and all kinds of trauma can cause cell degeneration, necrosis and tissue defect in different degrees, and tissue repair must be carried out through cell proliferation and formation of intercellular matrix. Although there are various types of drugs for treating trauma or hemostasis, a considerable part of the hemostatic drugs need to be taken orally to complete a series of complex physiological processes in the body, instead of simply acting directly on the blood vessels of the wound to achieve hemostasis. Purpose. Although some medicines can be directly applied to the wound, the medicine is dry, and the wound is easily involved when moving the wound, causing pain or cracking again, and because the medicine cannot be absorbed by the skin, it is necess...

Claims

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Application Information

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IPC IPC(8): A61L26/00A61L24/00A61L24/10C07K14/47C07K1/14
CPCA61L26/0028A61L24/0005A61L24/0015A61L24/0042A61L24/10A61L26/0057A61L26/0066A61L26/009A61L2300/30A61L2300/412A61L2300/418A61L2400/04C07K14/4741
Inventor 张娇张飞
Owner 北京东方艾美生物技术股份有限公司
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