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Composition prepared from two plant medicines and application of composition

A technology of composition and extract, applied in the preparation of compositions for the prevention and treatment of diabetes, in the field of compositions in which mango leaves and Stephania sinensis are compatible, can solve problems such as the unrecognized pharmacological effects of diabetes

Inactive Publication Date: 2017-03-15
宁波沪信药物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

People have not yet recognized its pharmacological effects on the prevention and treatment of diabetes

Method used

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  • Composition prepared from two plant medicines and application of composition
  • Composition prepared from two plant medicines and application of composition
  • Composition prepared from two plant medicines and application of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Embodiment 1 mango leaf and stephenia vine are compatible

[0053] Mix 0.3-7 parts of mango leaves with 0.1-5 parts of Stephania sinensis, and obtain test product 1 by powdering or decocting.

Embodiment 2

[0054] The preparation of embodiment 2 mango leaves and Stephania chinensis extract

[0055] Take 0.3 to 7 parts of mango leaves and 0.1 to 5 parts of Stephania sinensis by weight, add 90% ethanol for reflux extraction twice, the first ethanol is 8 times the amount, 2 hours, the second ethanol is 6 times the amount, After 1 hour, filter with double-layer gauze, combine the filtrates twice, recover ethanol under reduced pressure until there is no alcohol smell, and continue to concentrate under reduced pressure until the relative density is 1.30 at 55°C to obtain an extract, which is designated as test sample 2.

Embodiment 3

[0056] The preparation of embodiment 3 mangiferin

[0057] Referring to the content on page 161 of Volume 34, Issue 1, 2012 of "Chinese Patent Medicine", the mangiferin monomer compound was prepared and its structure was identified. The data are as follows:

[0058] ESIMS(m / z)421[M-H] - .

[0059] 1 H-NMR (400MHz, Pyridine-d 5 )δ14.62(s, 1H), 8.11(s, 1H), 7.18(s, 1H), 6.64(s, 1H), 5.88(d, J=10.0Hz, 1H), 5.28-5.23(m, 1H ), 4.60 (d, J=10.4Hz, 1H), 4.53-4.44 (m, 3H), 4.25-4.23 (m, 1H).

[0060] 13C-NMR (100MHz, Pyridine-d 5 )δ 182.4, 167.3, 165.2, 159.6, 158.1, 154.1, 147.5, 115.2, 111.3, 110.9, 105.4, 104.8, 96.3, 85.0, 82.7, 77.6, 74.8, 74.0, 64.9.

[0061] Commercial products of this compound can also be obtained, such as: Wuhan Hongxinkang Fine Chemical Company.

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Abstract

The invention discloses a composition prepared from two plant medicines, namely 0.3-7 parts of mango leaves and 0.1-5 parts of stephania sinica. The composition is prepared by performing backflowing extraction twice on 0.1-5 parts of stephania sinica with 50v / v-90v / v% ethanol, namely, performing backflowing extraction for 1-3 hours for the first time by using the 50v / v-90v / v% ethanol which is 8 times the amount of stephania sinica, and 1-2 hours for the second time by using the 50v / v-90v / v% ethanol which is 6 times the amount of stephania sinica, filtering, combining filtrate of the two times of backflowing extraction, performing depressurized recycling on the ethanol till no alcohol smell exists, and performing depressurized concentration continuously till the relative density is 1.20-1.34 at 50 DEG C + / -5 DEG C, thereby obtaining an extract. Animal tests show that the composition disclosed by the invention is capable of improving blood sugar and glycosylated hemoglobin, and has medicine development prospects.

Description

technical field [0001] The present invention relates to a composition obtained from plants, in particular to a composition compatible with mango leaves and stephenia chinensis, and the application of its extract and active ingredients in preparing a composition for preventing and treating diabetes. Background technique [0002] Diabetes Mellitus (DM) is a series of clinical syndromes caused by absolute or relative insufficiency of insulin in the body. The disease can also cause some complications during the development process, such as: hypoglycemia (Hypoglycemia), ketoacidosis (Ketoacidosis), nonketotic hyperosmolar coma (Nonketotic Hyperosmolar Coma), cardiovascular disease, chronic renal failure, retinal disease, neuropathy, and microvascular disease. There are three main categories of drugs commonly used in the treatment of diabetes: biological drugs, such as: insulin (Insulin); chemical drugs, such as: sulfonylureas (Sulfonylurea), biguanides (Biguanide), glitazones (G...

Claims

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Application Information

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IPC IPC(8): A61K36/59A61P3/10A23L33/105
CPCA23V2002/00A61K36/22A61K36/59A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2300/00A23V2200/328A23V2250/21
Inventor 袁宁生
Owner 宁波沪信药物技术有限公司
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