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Hyaluronic acid bacteriostatic gel

A technology of hyaluronic acid and gel, which is applied in the field of medicine, can solve the problems of not obvious bactericidal effect, easy infection of wounds, and uncomfortable use, so as to improve healing and regeneration ability, promote blood circulation and remove bruises, and avoid skin pits Effect

Inactive Publication Date: 2017-03-15
济南豪瑞生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The skin and mucous membranes covered by the human body are the body's defense line against the invasion of external pathogenic microorganisms. When a wound occurs, it is easy to be infected. At present, the common skin dressings on the market have no obvious bactericidal effect, or are obviously irritating and uncomfortable to use.

Method used

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  • Hyaluronic acid bacteriostatic gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Preparation of traditional Chinese medicine extract

[0023] 1) The composition of traditional Chinese medicine raw materials by weight is 30 parts of Bai Po, 30 parts of Angelica dahurica, 28 parts of Bai Fu Ling, 25 parts of Pueraria lobata, 23 parts of Tianhuafen, 22 parts of Atractylodes macrocephala, 22 parts of dandelion, 13 parts of forsythia, 12 parts of honeysuckle, 12 parts of red peony 12 parts, 12 parts of paeonol, 12 parts of Sophora flavescens, 12 parts of licorice.

[0024] 2) The above-mentioned Chinese medicine raw materials are ground into powder and passed through a 100-mesh sieve, mixed evenly, and 3 times the volume of 95% ethanol is added for reflux extraction for 4 hours, and 25 mg / ml promethazine hydrochloride-β-cyclodextrin is added to the crude extract to form an inclusion compound , evaporate the solvent under reduced pressure to obtain volatile oil extract; the dregs after reflux are dried, ultrafinely pulverized, soaked in 8 times the volume...

Embodiment 2

[0026] A hyaluronic acid antibacterial gel, the raw materials are composed of 55 parts by weight of hyaluronic acid, 35 parts of Chinese medicine extract, 18 parts of DCBA, 4 parts of ethanol, 5-86 parts of glycerol, and 12 parts of purified water;

[0027] Among them, the Chinese medicine extract, the composition of Chinese medicine raw materials by weight is 30 parts of white pomegranate, 30 parts of white peony, 28 parts of white poria cocos, 25 parts of kudzu root, 23 parts of trichosanthin, 22 parts of Atractylodes macrocephala, 22 parts of dandelion, 13 parts of forsythia, and 12 parts of honeysuckle .

[0028] The molar composition of hyaluronic acid is: molecular weight 1.8-2.2×10 6 53% hyaluronic acid, molecular weight 1.0-1.8×10 6 27% hyaluronic acid, molecular weight 0.4-1.0×10 6 of Hyaluronic Acid 30%.

[0029] Mix DCBA, 30-40 parts of traditional Chinese medicine extract, ethanol, glycerol and purified water evenly, filter, add hyaluronic acid under stirring, a...

Embodiment 3

[0031] A hyaluronic acid antibacterial gel, the raw materials are composed of 50 parts by weight of hyaluronic acid, 30 parts of Chinese medicine extract, 15 parts of DCBA, 3 parts of ethanol, 5 parts of glycerol, and 10 parts of purified water;

[0032] Among them, Chinese medicine extracts, Chinese medicine raw materials are composed of 25 parts by weight of white pomegranate, 25 parts of white peony, 25 parts of white poria cocos, 20 parts of kudzu root, 20 parts of trichosanthin, 20 parts of Atractylodes macrocephala, 20 parts of dandelion, 12 parts of forsythia, and 10 parts of honeysuckle .

[0033] The molar composition of hyaluronic acid is: molecular weight 1.8-2.2×10 6 55% hyaluronic acid, molecular weight 1.0-1.8×10 6 25% hyaluronic acid, molecular weight 0.4-1.0×10 6 of Hyaluronic Acid 20%.

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Abstract

The invention relates to a hyaluronic acid bacteriostatic gel, which comprises the following raw materials by weight: 50-60 parts of hyaluronic acid, 30-40 parts of a Chinese medicinal extract, 15-20 parts of DCBA, 3-5 parts of ethanol, 5-8 parts of glycerol, and 10-15 parts of purified water. The Chinese medicinal extract includes the following raw materials: Ampelopsis japonica, radix angelicae dahuricae, white poria, kudzuvine root, trichosanthes root, bighead atractylodes rhizome, dandelion, forsythia, honeysuckle, radix paeoniae rubra, cortex moutan, sophora flavescens and licorice. The hyaluronic acid bacteriostatic gel provided by the invention has bacteriostatic effect on staphylococcus aureus, escherichia coli, and pseudomonas aeruginosa, can be daubed on the skin to form a skin protective film, and is suitable for skin bacteriostasis, bacteriostatic protection postoperative skin wounds and daily skin care.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to an antibacterial gel, in particular to a hyaluronic acid antibacterial gel. Background technique [0002] Hyaluronic acid is a multifunctional matrix and one of the main components of the epidermis and dermis of human skin. Hyaluronic acid has high viscosity, plasticity, permeability, unique rheological properties and good biocompatibility, so the water transport in such tissues is slow, thus playing the role of regulating water distribution. This makes hyaluronic acid have a regulating effect on proteins and metabolites in the intercellular space, and also play a significant role as a lubricant. Studies have shown that hyaluronic acid plays a key role in regulating the migration behavior of various cellular components during embryogenesis. At the same time, it plays an important role in the tissue repair process, especially in the wound healing process of the skin. [0003] The...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/87A61K9/06A61P31/04A61P17/02A61P17/00A61P17/10A61K31/728A61K31/045
CPCA61K9/0014A61K9/06A61K31/045A61K31/728A61K36/076A61K36/232A61K36/284A61K36/288A61K36/355A61K36/428A61K36/484A61K36/488A61K36/489A61K36/634A61K36/65A61K36/71A61K36/87A61K2236/15A61K2236/331A61K2236/333A61K2236/51A61K2236/53A61K2300/00Y02A50/30
Inventor 房勇
Owner 济南豪瑞生物技术有限公司
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