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Manipulation method for moving magnetic nanoparticles

A magnetic nanoparticle and magnetic technology, which is applied in the field of manipulation of moving magnetic nanoparticles, can solve problems such as high difficulty, low success rate, and complicated manipulation, and achieve the effects of simple operation, avoiding path planning, and simplifying manipulation methods

Active Publication Date: 2017-03-15
CHANGCHUN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

For the above three methods, the equipment used must have a high enough resolution to achieve high-efficiency nanoscale manipulation, and the manipulation path needs to be designed according to the actual structure of the sample to be manipulated. For samples with complex structures, the manipulation is complicated. And more difficult, lower success rate

Method used

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  • Manipulation method for moving magnetic nanoparticles
  • Manipulation method for moving magnetic nanoparticles
  • Manipulation method for moving magnetic nanoparticles

Examples

Experimental program
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Effect test

Embodiment 1

[0035] Step (1): ultrasonically oscillate the ferroferric oxide magnetic nanoparticle solution with a concentration of 10 μg / mL and a particle size of 10 to 50 nm for 3 times, each time for 10 minutes, and set the temperature at 20 degrees Celsius to obtain evenly dispersed nanoparticles solution.

[0036] Step (2): 2.5 μL of uniformly dispersed ferroferric oxide magnetic nanoparticle solution was dropped on a 10 mm×10 mm mica substrate, and air-dried naturally in a clean environment.

[0037] Step (3): Place the dried magnetic nanoparticle sample on the sample stage of the magnetic force microscope, set the working mode of the magnetic force microscope to Tapping mode, scan the surface of the sample, and select an area with a range of 0.4 μm × 0.65 μm as the sample to be tested. manipulation areas such as image 3 As shown, (a) is the topography image of the distribution of magnetic nanoparticles before manipulation, and (b) is the corresponding magnetic domain image.

[00...

Embodiment 2

[0043] Figure 6 Shown is a diagram of the manipulation results of continuously transporting three magnetic nanoparticles using the manipulation method of the present invention.

[0044] Step (1): ultrasonically oscillate the ferroferric oxide magnetic nanoparticle solution with a concentration of 10 μg / mL and a particle size of 10 to 50 nm for 3 times, each time for 10 minutes, and set the temperature at 20 degrees Celsius to obtain evenly dispersed nanoparticles solution.

[0045] Step (2): 2.5 μL of uniformly dispersed ferroferric oxide magnetic nanoparticle solution was dropped on a 10 mm×10 mm mica substrate, and air-dried naturally in a clean environment.

[0046] Step (3): Place the dried magnetic nanoparticle sample on the sample stage of the magnetic force microscope, set the working mode of the magnetic force microscope to Tapping mode, scan the surface of the sample, and select an area with a range of 0.4 μm × 0.65 μm as the area to be manipulated area, Figure 6...

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Abstract

The invention discloses a manipulation method for moving magnetic nanoparticles. A magnetic nanoparticle solution is oscillated by using an ultrasonic cleaner; the uniformly-dispersed magnetic nanoparticle solution after oscillation is dripped on a mica substrate, natural air drying is carried out in a clean environment, and a to-be-manipulated sample is obtained; the well-made sample is placed on a magnetic force microscope sample table, and a magnetic force probe is used for carrying out scanning imaging on the to-be-manipulated sample; a magnetic nanoparticle in a to-be-manipulated area is selected as a target particle for moving manipulation, a spiral line serves as a manipulation path from outside to an inner circle, and finally, the spiral line is ended at a position with the particle as a center; the probe is driven to contact the mica surface, and the probe is made to approach to the target magnetic nanoparticle along the designed spiral line structure path; the probe is driven to lift to leave the surface of the mica substrate; and a target area is scanned, and whether the manipulated particle is moved away from the mica surface is determined. The manipulation method of the invention is simple, and the target magnetic nanoparticle can be moved away from the original position accurately.

Description

technical field [0001] The invention relates to a manipulation method for moving magnetic nanoparticles, belonging to the technical field of nanometer manipulation. Background technique [0002] Magnetic Nanoparticles (MNPs) have different physical and chemical properties such as biocompatibility and superparamagnetism. They are magnetic materials with a wide range of applications. They can not only be used in cancer treatment and diagnosis, drug loading, magnetic Biological fields such as resonance imaging (MRI) can also be applied in other different fields such as sewage treatment and electronic devices. The magnetic force microscope (Magnetic Force Microscope, MFM) is developed from the atomic force microscope (Atomic Force Microscope, AFM). Can be used to manipulate magnetic samples. [0003] Currently, in terms of nanomanipulation, commonly used manipulation methods include pushing, rolling and sliding. Push and manipulate the probe to apply force behind or in front ...

Claims

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Application Information

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IPC IPC(8): G01Q60/56
CPCG01Q60/56
Inventor 王作斌刘劲芸李大有张文晓宋正勋翁占坤许红梅董莉彤
Owner CHANGCHUN UNIV OF SCI & TECH
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