18f-labeled pi3k/akt signaling pathway inhibitor s14161 and its preparation method and application
A labeling and reaction technology, applied in the field of medicine, achieves the effects of simple and easy-to-control preparation process, mild reaction conditions, and simple and convenient separation
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Embodiment 1
[0029] Embodiment 1: Synthesis of 2-hydroxyl-1-ethoxy-3-(2-nitrovinyl)benzene
[0030] Add 1.1g of ammonium acetate and 4.64ml of glacial acetic acid to the four-necked flask successively, stir, after fully dissolving, add 1mmol of 2-hydroxy-1-ethoxy-3-formylbenzene and 4mmol of nitromethane in sequence , heated to reflux, and reacted for 5 hours. After the reaction was monitored by TLC, the reaction solution was cooled to room temperature, then poured into crushed ice, stirred for 0.5 hours, and filtered with suction to obtain an orange crystalline compound, namely 2-hydroxyl-1-ethoxy Base-3-(2-nitrovinyl)benzene; purity 95%, yield 93%. ESI-MS(m / z):209(M + ); 1 H NMR (DMSO-d 6 ,,400MHz), δ:13.75(s,1H,OH),8.08(d,1H,J=7.85Hz,Ar-CH),8.19(d,1H,J=7.89Hz,CHNO 2 ), 6.61-7.15 (m, 3H, Ar-H), 4.09 (m, 2H, CH 2 O),1.4(t,3H,CH 3 CH 2 -), 13 CNMR (CDCl 3 ,125MHz) δ: 151.3, 148.1, 137.5, 138.8, 121.2, 120.1, 117.5, 114.9, 63.2, 14.5.
[0031]
Embodiment 2
[0032] Example 2: Synthesis of 8-ethoxy-2-(4-tert-butoxycarbonylaminophenyl)-3-nitro-2H-chromene
[0033] Add 10mmol of 2-hydroxyl-1-ethoxy-3-(2-nitrovinyl)benzene, 12mmol of 4-tert-butoxycarbonylaminobenzaldehyde, 1mmol of anhydrous potassium fluoride, 5mmol Triethylenediamine (DABCO), 10 mmol of dimethylamine hydrochloride, 72.6 ml of toluene, the mixture was heated to 110 ° C, and stirred for 12 h. Dichloromethane and water were added to the reaction solution, the organic phase was separated, dried over anhydrous magnesium sulfate, and the solvent was evaporated to obtain 8-ethoxy-2-(4-tert-butoxycarbonylaminophenyl)-3-nitrate Base-2H-chromene, the yield is 70%, ESI-MS (m / z): 368 (M + ); 1 H NMR (DMSO-d 6 ,,400MHz)δ:9.79(s,1H,NH),7.88(s,1H,NO 2 CCH), 6.61-7.58 (m, 7H, Ar-H), 5.6 (s, 1H, OCH), 4.13 (m, 2H, CH 2 O),1.48(d,9H,3×CH 3 ), 1.39(t,3H,CH 3 CH 2 -), 13 CNMR (CDCl 3 ,125MHz)δ:147.1,81.3,148.9,145.3,136.1,115.1,136.9,121.3,121.8,120.3,127.6,114.1,121.3,127.5,...
Embodiment 3
[0035] Example 3: Synthesis of the triflate salt of 8-ethoxy-2-(4-aminophenyl)-3-nitro-2H-chromene
[0036] Add 10mmol of 8-ethoxy-2-(4-tert-butoxycarbonylaminophenyl)-3-nitro-2H-chromene, 15mmol of trifluoromethanesulfonic acid, 59.3ml of dichloromethane into the reaction flask , stirred at room temperature for 0.5h, after the completion of the reaction monitored by TLC, the solvent was evaporated to dryness to obtain trifluoromethanesulfonic acid of 8-ethoxy-2-(4-aminophenyl)-3-nitro-2H-chromene. The rate is 90%. ESI-MS(m / z):459(M + ); 1 H NMR (DMSO-d 6 ,,400MHz)δ:6.63-7.56(m,7H,Ar-H),7.35(s,3H,NH 3 ),7.65(s,1H,NO 2 CCH), 5.66(s,1H,OCH), 4.11(m,2H,CH 2 O),1.39(t,3H,CH 3 CH 2 -). 13 CNMR (CDCl 3 ,125MHz) δ: 148.3, 82.0, 149.1, 145.8, 133.1, 115.5, 141.2, 121.5, 121.4, 120.3, 127.5, 114.3, 121.5, 127.3, 121.6, 28.6, 64.3, 14.9.
[0037]
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