Neurovascular coupling analysis method based on EEG and functional near-infrared spectroscopy
A near-infrared spectrum and functional technology, applied in the field of neurovascular coupling analysis, can solve the problems of limited development, expensive, heavy equipment, etc., and achieve the effect of overcoming limitations
Active Publication Date: 2020-02-14
INST OF AUTOMATION CHINESE ACAD OF SCI
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Although the spatial resolution of functional magnetic resonance (fMRI) is high, it can be combined with electroencephalography (EEG) with high temporal resolution to form a complementary advantage, but due to the strong noise interference of its magnetic field signal and EEG electrical signal, In addition, fMRI has strict requirements on the subjects and the environment, and its equipment is heavy and expensive, which limits the development of EEG-fMRI fusion technology to a certain extent.
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[0040] Preferred embodiments of the present invention are described below with reference to the accompanying drawings. Those skilled in the art should understand that these embodiments are only used to explain the technical principles of the present invention, and are not intended to limit the protection scope of the present invention.
[0041] The basic idea of the embodiment of the present invention is based on a photoelectric synchronous brain activity detection system, which uses EEG technology and functional near-infrared technology to simultaneously collect neuron electrical activity and changes in blood oxygen metabolism in the same brain area, and uses two modes of light and electricity Data, from the perspective of time characteristics, neurovascular coupling analysis of EEG and cerebral blood oxygen dual-modal fusion.
[0042] Here, the relationship between neuron electrical activity and blood oxygen response is described in terms of time characteristics, that is, ...
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The invention relates to a neurovascular coupling analytical method based on electroencephalogram and functional near infrared spectroscopy technology. The method comprises: acquiring electroencephalogram signals and brain blood oxygen signals; extracting event-related potential signals from the electroencephalogram signals; extracting time characteristics from the event-related potential signals; extracting blood oxygen response function signals from the brain blood oxygen signals; extracting amplitude characteristics and time characteristics from the blood oxygen response function signals; analyzing influence of the time characteristics of the event-related potential signals on the amplitude characteristics and time characteristics of the blood oxygen response function signals, to obtain a coupling result. Embodiments describe relationships of neuronal electric-activities and blood oxygen response from the aspect of time, overcoming shortage of research on time characteristics of the blood oxygen response and neuronal electric-activities in conventional neurovascular coupling analysis.
Description
technical field [0001] The invention relates to the technical field of EEG and functional near-infrared spectroscopy, in particular to a neurovascular coupling analysis method based on EEG and functional near-infrared spectroscopy. Background technique [0002] Brain functional activities include multiple processes such as neuron activity and local energy metabolism. Complex functional activities allow the brain to gather information from multiple modalities, the most important of which are the electrical activity of neurons and changes in blood oxygen metabolism in activated areas. The relationship between the two is called neurovascular coupling (Neurovascular Coupling). This complex coupling process requires a series of activities between neurons, astrocytes and capillaries. However, the basis for using blood oxygen changes to infer neuron activity in neuroscience research is not yet clear, which affects the judgment of neuron activity to a certain extent. [0003] Usin...
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IPC IPC(8): A61B5/00A61B5/0476A61B5/145
CPCA61B5/0075A61B5/145A61B5/7203A61B5/7225A61B5/7285A61B5/369
Inventor 蒋田仔张鑫左年明司娟宁
Owner INST OF AUTOMATION CHINESE ACAD OF SCI