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Application of JNK inhibitor in preparing drug

A technology for preparing drugs and inhibitors, applied in the field of biomedicine, can solve the problems of poor sensitivity of antifungal drugs, increased drug resistance of Candida, inability to prevent non-Candida albicans infection, etc., and achieves good prevention and treatment effects and therapeutic effects. Good, inhibiting the effect of activation

Active Publication Date: 2017-04-26
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Fluconazole cannot prevent non-albicans infections, and abuse will increase the resistance of Candida to fluconazole, resulting in a reduction in Candida albicans and Candida tropicalis infections, while other Candida species, such as Candida glabrata and Candida krusei Bacteria that are less susceptible to antifungal drugs
[0004] Therefore, the medicine for prevention and treatment of fungal infection needs to be improved

Method used

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  • Application of JNK inhibitor in preparing drug
  • Application of JNK inhibitor in preparing drug
  • Application of JNK inhibitor in preparing drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] In this experiment, the preventive effect of JNK inhibitors on fungal infection was studied. First, wild-type mice were intraperitoneally injected with JNK inhibitor SP600125 or a control solvent, and then infected with Candida albicans through tail vein injection 24 hours later. At the same time, JNK inhibitors were injected daily. agent to observe the survival rate of mice.

[0051] 1. Animals and reagents

[0052] (1) Experimental mice: wild-type C57BL / 6 mice for experimentation, purchased from Victoria Lihua Company, and kept in the SPF-grade clean breeding room of the experimental animal platform of Tsinghua University, a total of 30 mice, age: 8 weeks, gender : Half male and half male.

[0053] (2) Bacterial strains used in the experiment: clinical strains of Candida albicans used in the experiment: sc5314, activated with YPD medium for 48 hours before infection, resuspended Candida albicans with PBS and washed the YPD medium attached to the surface of Candida al...

Embodiment 2

[0060] In this experiment, the preventive effect of JNK inhibitors on fungal infections was studied. First, wild-type mice were injected intraperitoneally with JNK inhibitor SP600125 or a control solvent. After 24 hours, they were infected with Candida albicans through the tail vein, and the mice’s kidneys were observed. quantity.

[0061] 1. Animals and reagents

[0062] (1) Experimental mice: experimental wild-type C57BL / 6 mice were purchased from Victoria Lihua Co., Ltd., and were raised in an SPF-grade clean breeding room in the experimental animal platform of Tsinghua University. There were 6 mice in total, aged 8 weeks.

[0063] (2) Bacterial strains used in the experiment: clinical strains of Candida albicans used in the experiment: sc5314, activated with YPD medium for 48 hours before infection, resuspended Candida albicans with PBS and washed the YPD medium attached to the surface of Candida albicans with Resuspend Candida albicans in PBS, and take the corresponding ...

Embodiment 3

[0070] In this experiment, the preventive effect of JNK inhibitors on fungal infection was studied. First, wild-type mice were intraperitoneally injected with JNK inhibitor JNK-IN-8 or a control solvent, and then infected with Candida albicans through tail vein injection after 24 hours. Supplementary injection of JNK inhibitor was performed to observe the survival rate of mice.

[0071] 1. Animals and reagents

[0072] (1) Experimental mice: wild-type C57 / B6 background mice were purchased from Jackson Laboratory in the United States, and were raised in an SPF-grade clean breeding room in the experimental animal platform of Tsinghua University. There were 20 mice in total, age: 8 weeks, gender: male and female Half and half.

[0073] (2) Bacterial strains used in the experiment: clinical strains of Candida albicans used in the experiment: sc5314, activated with YPD medium for 48 hours before infection, resuspended Candida albicans with PBS and washed the YPD medium attached to...

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Abstract

The invention discloses an application of a JNK inhibitor in preparing a drug. The medicines are used for preventing and treating fungal infection. The JNK inhibitor, as a gene target drug, is capable of conducting targeted therapy on the fungal infection, and the drug is strong in application and is capable of effectively improving the capacity of a body's immune system to resist the fungal infection, so as to prevent and treat the fungal infection. The JNK inhibitor can enhance the accuracy of fungus treatment from body self, and the JNK inhibitor can effectively prevent the occurrence of drug-resistance bacteria, so that a curative effect of preventing and treating the fungal infection is obviously improved. In addition, the JNK inhibitor, in comparison with existing broad-spectrum anti-fungal drugs, is low in cost and cheap in price, and the JNK inhibitor is relatively high in economic significance and clinical application value.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the use of JNK inhibitors in the preparation of medicines. Background technique [0002] Systemic fungal infection is life-threatening, and it is easy to invade immunocompromised patients, such as HIV patients, bone marrow transplant patients, tumor patients and solid organ transplant patients. Due to the non-specificity of systemic fungal infection, clinical diagnosis is difficult. Clinically, it is easily covered by complications such as bacterial infection and viral infection. Despite continuous improvements in diagnostic techniques for systemic fungal infections, preventive and empiric treatment still plays an important role in systemic fungal infections. However, empiric antifungal treatment for high-risk patients or patients with unexplained fever and ineffective broad-spectrum antibiotics is closely related to the prognosis of systemic fungal infection. At present, there are ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/506A61K31/416A61K45/00A61K45/06A61P31/10
CPCA61K31/416A61K31/506A61K45/00A61K45/06A61K2300/00
Inventor 赵学强郭亚慧林欣
Owner TSINGHUA UNIV
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