Injector-connector emulsification system and emulsion preparation method

Abstract

The invention aims at making the small-dosage antigen and adjuvant emulsion process simple and easy and providing a plastic connector for oppositely connecting two injector cone heads, an emulsification system and a corresponding emulsification operation method. The connector comprises two connecting seats, wherein the connecting seats are hollow. The connecting seats are communicated through a PVC tube, the outer walls of two ends of the communicating tube are adhered to the inner wall of hollow tubes of the connecting seats, and the hose length between the connecting seats is controlled to be 1 cm. Convex lugs at the interface ends of the connecting seats can be embedded into screw sockets of screw injectors and can resist a powerful pressure during emulsification and push of the injectors and make connection firm. Side wings of the connecting seats facilitate handheld rotation in the butt joint and dismounting process. The whole transparency of the connector facilitates observation of internal liquid and air bubbles in the tubes, the inner diameter of the connecting seats is matched with the outer diameter size of the cone heads, and an operator can more conveniently discharge out residual air bubbles at the connector compared with a transparent rubber tube of a disposable infusion apparatus. The whole emulsification system plays the effect of connecting the two injectors to make two types of liquid mixed completely.

Description

[0001] The invention relates to a plastic connector, an emulsification system composed of a syringe-connector-syringe, and an operation method of the system for preparing a small-dose antigen emulsion. Background technique [0002] Immunotherapy of tumor antigens is one of the most popular research directions in the field of biomedicine at present. A variety of new antigens and new adjuvants have been developed for the treatment of various tumors and other diseases. [0003] At present, the emulsification process of small doses of water-in-oil emulsions is very inconvenient. Classical emulsification methods, such as mortar grinding method, vortex oscillation method, stirrer stirring method, etc., have uneven emulsification quality, which is not conducive to maintaining the sterility of the emulsion, and a large number of antigens or vaccines adhere to the utensils, resulting in waste. In actual operation, the transparent rubber tube on the disposable infusion set is commonly u...

AI Technical Summary

Problems solved by technology

Since the connector is used repeatedly in the cleaning-use-cleaning mode, it is difficult to ensure the sterility of the emulsion, which limits the use of the prepared emulsion on the human body; in addition, the connector is a non-transparent structure, which is not conducive to the discharge of the syringe-connection Air bubbles in the container system, affecting the particle size and uniformity of the emulsion

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