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Circulation extraction method of sinomenine hydrochloride from orientvine

A sinomenine hydrochloride, recycling extraction technology, applied in the direction of organic chemistry, can solve the problems of high consumption and low extraction efficiency of extract components, and achieve the effects of reducing energy consumption, increasing the content of sinomenine, and high extraction efficiency

Active Publication Date: 2017-05-10
HUNAN ZHENGQING PHARM GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is the problem that the extraction efficiency of the extract components is low due to the excessive consumption of the percolation solvent of the extract of Caulis sinensis hydrochloric acid in the prior art, and then provides a preparation of Qingfengteng hydrochloric acid extract with less solvent consumption and high extraction efficiency. The method of vine extract

Method used

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  • Circulation extraction method of sinomenine hydrochloride from orientvine
  • Circulation extraction method of sinomenine hydrochloride from orientvine
  • Circulation extraction method of sinomenine hydrochloride from orientvine

Examples

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Embodiment 1

[0029] The method for cyclically extracting sinomenine hydrochloride from S. chinensis of the present embodiment comprises the following steps:

[0030] (1) Get 600g of raw material coarse powder of Teng chinensis, add 600ml of 0.3mol / L HCL solution to infiltrate for 2 hours, put into 4 interconnected percolation cylinders in equal amounts respectively, then add 0.3mol / L of HCl to make each Exhaust the cylinder and fill it with hydrochloric acid solution, connect each percolation cylinder, and soak for 12 hours;

[0031] (2) Use 0.3mol / L HCL solution as the percolation liquid, open the top liquid inlet of the first-stage percolation cylinder, and start from the first-stage percolation cylinder at a rate of 8-10ml / min per kilogram of medicinal material Carry out continuous percolation operation, open the bottom liquid outlet of the fourth-stage percolation cylinder, and collect 1200ml of primary filtrate;

[0032] (3) After collecting the primary eluate of each percolation cyl...

Embodiment 2

[0036] The method for cyclically extracting sinomenine hydrochloride from S. chinensis of the present embodiment comprises the following steps:

[0037] (1) Take 600g of Qingfengteng coarse powder, add 600ml of 0.3mol / L HCL solution to infiltrate for 2 hours, put them into two percolation cylinders connected in series, and then add 0.3mol / L HCl to make each cylinder Exhaust and fill with hydrochloric acid solution, connect each percolation cylinder, and soak for 12 hours;

[0038] (2) Use 0.3mol / L HCL solution as the percolation liquid, open the top liquid inlet of the first-stage percolation cylinder, and start from the first-stage percolation cylinder at a rate of 8-10ml / min per kilogram of medicinal material Carry out continuous percolation operation, open the liquid outlet at the bottom of the second-stage percolation cylinder, and collect 1200ml of primary filtrate;

[0039] (3) After collecting the primary eluate of each percolation cylinder, close the top liquid inlet of...

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Abstract

The invention provides a circulation extraction method of sinomenine hydrochloride from orientvine. The circulation extraction method comprises the following steps: taking orientvine raw materials and adding the orientvine raw materials to 0.1 to 1mol / L of an HCL solution to be soaked for 6.5 to 30h, and respectively placing into 2 to 5 percolators which are connected in parallel mutually to be percolated and extracted again. The extraction method disclosed by the invention is high in extraction efficiency, less in solvent volume, and can be widely applied to the extraction field of Chinese herbal effective components.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine extraction technology, and in particular relates to a method for circularly extracting sinomenine hydrochloride from Caulis chinensis. Background technique [0002] Qingfengteng is a commonly used Chinese herbal medicine. It is flat in nature, bitter and pungent in taste, and returns to the liver and spleen meridian. It has the effects of dispelling rheumatism, dredging the meridian, and urinating. It is mainly used in the treatment of rheumatic arthralgia, joint swelling, and numb itching. [0003] The main components of Qingfengteng are alkaloids, and the ingredients that have been found so far are sinomenine, isosinomenine, sinomenine, short sinomenine, sharp sinomenine, double sinomenine, ethyl sinomenine Alkali, tetrahydroepiberberine, bat quizoline, bat gening and tetrahydropalmatine, etc. [0004] Sinomenine is an alkaloid monomer extracted from S. sinensis. It is the main acti...

Claims

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Application Information

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IPC IPC(8): C07D221/28
CPCC07D221/28
Inventor 彭祖仁仇萍滕健吴飞驰
Owner HUNAN ZHENGQING PHARM GRP CO LTD
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