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Preparation method for methyl testosterone molecularly imprinted polymer

A methyltestosterone, molecular imprinting technology, applied in chemical instruments and methods, other chemical processes, etc., can solve the problems of less specific adsorption and low adsorption capacity, and achieve good adsorption kinetics, fast adsorption speed, and good adsorption selection. sexual effect

Active Publication Date: 2017-05-10
ZHEJIANG PHARMA COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing solid-phase extraction materials of methyltestosterone have the disadvantages of low adsorption capacity and less specific adsorption.

Method used

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  • Preparation method for methyl testosterone molecularly imprinted polymer
  • Preparation method for methyl testosterone molecularly imprinted polymer
  • Preparation method for methyl testosterone molecularly imprinted polymer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A method for preparing a molecularly imprinted polymer of methyltestosterone, comprising the following steps:

[0019] 1) Add 12mL of distilled water and 0.8g of methyltestosterone solid powder into a 100mL round bottom flask, heat to dissolve;

[0020] 2) Add 1.2mL 3-aminopropyltriethoxysilane to the round bottom flask, stir, react for 10min, add 1.5mL tetraethoxysilane, and continue stirring for 10min;

[0021] 3) Add 1.0 mL of 0.1mol / L acetic acid to the round bottom flask in step 2), heat in a water bath at 45-50°C for 10 hours, filter to obtain a polymer containing template molecules, wash the polymer containing template molecules with ethanol, and then Placed in a vacuum oven at 100°C for 8 h of aging treatment;

[0022] 4) Put the aging-treated polymer containing template molecules in a round-bottomed flask, add 50 mL of ethanol and 10 mL of 1mol / L hydrochloric acid, stir for 2 hours, filter, wash with ethanol and water in turn, and then wash with 0.1mol / L wash...

Embodiment 2

[0025] A method for preparing a molecularly imprinted polymer of methyltestosterone, comprising the following steps:

[0026] 1) Add 12mL distilled water and 0.5g methyltestosterone solid powder into a 100mL round bottom flask, heat to dissolve;

[0027] 2) Add 1.5mL 3-aminopropyltriethoxysilane to the round bottom flask, stir, react for 10min, add 1.8mL tetraethoxysilane, and continue stirring for 10min;

[0028] 3) Add 1 mL of 0.1mol / L acetic acid to the round-bottomed flask in step 2), heat in a water bath at 45°C for 10 hours, filter to obtain the polymer containing template molecules, wash the polymer containing template molecules with ethanol, and place in Aging treatment at 100°C for 8 h in a vacuum oven;

[0029] 4) Put the aging-treated polymer containing template molecules in a round bottom flask, add 50 mL of ethanol and 12 mL of 1mol / L hydrochloric acid, stir for 2 hours, filter, wash with ethanol and water in turn, and then wash with 0.1mol / L washed with sodium ...

Embodiment 3

[0032] A method for preparing a molecularly imprinted polymer of methyltestosterone, comprising the following steps:

[0033] 1) Add 12mL of distilled water and 0.8g of methyltestosterone solid powder into a 100mL round bottom flask, heat to dissolve;

[0034] 2) Add 1.8mL 3-aminopropyltriethoxysilane to the round bottom flask, stir, react for 20min, add 1.8mL tetraethoxysilane, and continue stirring for 10min;

[0035] 3) Add 1.2 mL of 0.1mol / L acetic acid to the round bottom flask in step 2), heat in a water bath at 45-50°C for 10 hours, filter to obtain the polymer containing template molecules, wash the polymer containing template molecules with ethanol, and then Placed in a vacuum oven at 100°C for 8 h of aging treatment;

[0036] 4) Put the aging-treated polymer containing template molecules in a round-bottomed flask, add 50 mL of ethanol and 15 mL of 1mol / L hydrochloric acid, stir for 1-2 hours, filter, wash with ethanol and water in turn, and then wash with 0.1mol / L...

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Abstract

The invention discloses a preparation method for methyl testosterone molecularly imprinted polymer. The preparation method comprises the following steps: 1) adding 10-12 mL of distilled water and 0.5-0.8 g of methyl testosterone solid powder to 100 mL of a round-bottom flask, heating and dissolving; 2) adding 1.2-1.8 mL of 3-amino propyl triethoxy silane to the round-bottom flask, stirring, and adding 1.5-1.8 mL of tetraethoxysilane after reacting for 10-20 min, continuously stirring for 5-10 min; and 3) adding acetic acid to the round-bottom flask of the step 2), heating by water bath, and filtering to obtain the polymer containing template molecule. The methyl testosterone molecularly imprinted polymer prepared by the method has large adsorption capacity and good selective combining capacity.

Description

technical field [0001] The invention relates to a preparation method of a molecularly imprinted polymer of methyltestosterone. Background technique [0002] Before the detection and analysis of complex samples, the target substances in the samples are separated and enriched by using solid phase extraction technology. The interaction between the target substance and the adsorbent in traditional solid-phase extraction is non-specific. It usually requires careful selection of extraction and elution conditions, and sometimes it is difficult to completely remove the interference of the matrix. Molecularly imprinted polymers are very suitable as SPE extraction materials to separate and enrich analytes in complex matrices due to their simple preparation, high mechanical strength, good stability, high selectivity to target objects, and diversity of template selection. However, the existing solid-phase extraction materials for methyltestosterone have the disadvantages of low adsorpt...

Claims

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Application Information

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IPC IPC(8): C08G77/26C08J9/26B01J20/26B01J20/30
CPCB01J20/268C08G77/26C08J9/26C08J2383/08
Inventor 赵冬艳张境王彩萍
Owner ZHEJIANG PHARMA COLLEGE
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